Reading List

The N-terminal PAS domain directly regulates hERG channel gating in excised, inside-out patch-clamp fluorometry (PCF) recordings

1. Matthew C. Trudeau

Distinct mechanisms of inhibition of Kv2 potassium channels by tetraethylammonium and RY785

1. Shan Zhang
2. Robyn Stix
3. Esam A Orabi
4. Nathan Bernhardt
5. José D Faraldo-Gómez

• Curated by eLife

  eLife Assessment

  This study represents an important advance in our understanding of how certain inhibitors affect the behavior of voltage gated potassium channels. Robust molecular dynamics simulation and analysis methods lead to a new proposed inhibition mechanism with strength of support being mostly convincing, and incomplete in some aspects. This study has considerable significance for the fields of ion channel physiology and pharmacology and could aid in development of selective inhibitors for protein targets.

Reviewed by eLife

Single-molecule detection of transient dimerization of opioid receptors 2: Heterodimer blockage reduces morphine tolerance

1. Peng Zhou
2. Rinshi S. Kasai
3. Wakako Fujita
4. Taka A. Tsunoyama
5. Hiroshi Ueda
6. Simone Pigolotti
7. Takahiro K. Fujiwara
8. Akihiro Kusumi

Memorization Bias Impacts Modeling of Alternative Conformational States of Symmetric Solute Carrier Membrane Proteins with Methods from Deep Learning

1. G.V.T. Swapna
2. Namita Dube
3. Monica J. Roth
4. Gaetano T. Montelione

Molecular insights into the modulation of the 5HT _2A receptor by serotonin, psilocin, and the G protein subunit Gqα

1. Niklas Viohl
2. Ali Asghar Hakami Zanjani
3. Himanshu Khandelia

Parametrically guided design of beta barrels and transmembrane nanopores using deep learning

1. David E. Kim
2. Joseph L. Watson
3. David Juergens
4. Sagardip Majumder
5. Ria Sonigra
6. Stacey R. Gerben
7. Alex Kang
8. Asim K. Bera
9. Xinting Li
10. David Baker

Stabilized D ₂ R G-protein coupled receptor oligomers identify multi-state β-arrestin complexes

1. Katie L. Sharrocks
2. Francesca Fanelli
3. Yewei Lui
4. Annabelle J. Milner
5. Wu Yining
6. Bernadette Byrne
7. Aylin C. Hanyaloglu

Arrestin recognizes GPCRs independently of the receptor state

1. Ivana Petrovic
2. Meltem Tatli
3. Samit Desai
4. Anne Grahl
5. Dongchun Ni
6. Henning Stahlberg
7. Anne Spang
8. Stephan Grzesiek
9. Layara Akemi Abiko

Ideal efficacy photoswitches for TRPC4/5 channels harness high potency for spatiotemporally-resolved control of TRPC function in live tissues

1. Markus Müller
2. Konstantin Niemeyer
3. Navin K. Ojha
4. Sebastian A. Porav
5. Deivanayagabarathy Vinayagam
6. Nicole Urban
7. Fanny Büchau
8. Katharina Oleinikov
9. Mazen Makke
10. Claudia C. Bauer
11. Aidan V. Johnson
12. Stephen P. Muench
13. Frank Zufall
14. Dieter Bruns
15. Yvonne Schwarz
16. Stefan Raunser
17. Trese Leinders-Zufall
18. Robin S. Bon
19. Michael Schaefer
20. Oliver Thorn-Seshold

Functional properties of a disease mutation for migraine in Kv2.1/6.4 channels

1. Debanjan Tewari
2. Christian Sattler
3. Klaus Benndorf

Selective Activation of GPCRs: Molecular Dynamics Shows Siponimod Binds but Fails to Activate S1PR2 Unlike S1PR1

1. Kumari Soniya
2. Kruthika Avadhani
3. Chanukya Nanduru
4. Antarip Halder

From resting state to inactivation: the dynamic journey of the inactivation peptide in Shaker Kv channels

1. Roshan Pandey
2. Tanja Kalstrup
3. Rikard Blunck

Regulation of Kv1.2 redox-sensitive gating by the transmembrane lectin LMAN2

1. Shawn M. Lamothe
2. Damayantee Das
3. Anson A. Wong
4. Yubin Hao
5. Aislinn D. Maguire
6. Bradley J. Kerr
7. Victoria A. Baronas
8. Harley T. Kurata

Transient TELC and transmembrane potential in a laser flashed bacteriorhodopsin purple membrane open flat sheet

1. James Weifu Lee

Cryo-EM structures of Clostridium perfringens enterotoxin bound to its human receptor, claudin-4

1. Sewwandi S. Rathnayake
2. Satchal K. Erramilli
3. Anthony A. Kossiakoff
4. Alex J. Vecchio

Proteostasis landscapes of cystic fibrosis variants reveal drug response vulnerability

1. Eli Fritz McDonald
2. Minsoo Kim
3. John A. Olson
4. Jens Meiler
5. Lars Plate

TRPML1 gating modulation by allosteric mutations and lipids

1. Ninghai Gan
2. Yan Han
3. Weizhong Zeng
4. Youxing Jiang

• Curated by eLife

  eLife Assessment

  Transient receptor potential mucolipin 1 (TRPML1) functions as a lysosomal ion channel whose variants are associated with lysosomal storage disorder mucolipidosis type IV. This important report describes local and global structural changes driven by binding of regulatory phospholipids and by mutations that allosterically cause gain or loss of channel function. Most of the claims related to the allosteric regulation of TRPML1 are convincingly supported by two new cryo-EM structures which are evaluated within the context of previously reported TRPML1 structures, and a proposed allosteric gating mechanism is partially supported by functional electrophysiology results.

Reviewed by eLife

Ion and water permeation through claudin-10b and claudin-15 paracellular channels

1. Alessandro Berselli
2. Giulio Alberini
3. Fabio Benfenati
4. Luca Maragliano

N -Glycosylation of MRS2 balances aerobic and anaerobic energy production by reducing rapid mitochondrial Mg ²⁺ influx in conditions of high glucose or impaired respiratory chain function

1. Min Peng
2. Neal D. Mathew
3. Vernon E. Anderson
4. Marni J. Falk
5. Eiko Nakamaru-Ogiso

FKBP12-BOUND CALCINEURIN CONTROL TMEM16A ACTIVITY

1. María Luisa Guzmán-Hernández
2. Miriam Huerta
3. Ana E. López-Romero
4. Rita Morán-Zendejas
5. Abigail Betanzos
6. Patricia Pérez-Cornejo
7. Jorge Arreola