Reading List

Voltage-dependent G-protein regulation of Ca _V 2.2 (N-type) channels

1. Michelle Nilsson
2. Kaiqian Wang
3. Teresa Mínguez-Viñas
4. Marina Angelini
5. Stina Berglund
6. Riccardo Olcese
7. Antonios Pantazis

The fully activated open state of KCNQ1 controls the cardiac “fight-or-flight” response

1. Panpan Hou
2. Lu Zhao
3. Ling Zhong
4. Jingyi Shi
5. Hong Zhan Wang
6. Junyuan Gao
7. Huilin Liu
8. Joan Zuckerman
9. Ira S Cohen
10. Jianmin Cui

GerAB residues predicted to interfere with water passage based on steered Molecular Dynamics are key to germinosome stability

1. Longjiao Chen
2. Houdijn Beekhuis
3. Christina van den Bosch
4. Gianni Vinay
5. George Korza
6. Jocelyne Vreede
7. Peter Setlow
8. Stanley Brul

CryoEM Structure of the human THIK-1 K2P K ⁺ Channel Reveals a Lower ‘Y-gate’ Regulated by Lipids and Anaesthetics

1. Karin EJ Rödström
2. Bisher Eymsh
3. Peter Proks
4. Mehtab S Hayre
5. Christian Madry
6. Anna Rowland
7. Simon Newstead
8. Thomas Baukrowitz
9. Marcus Schewe
10. Stephen J Tucker

Structure of the human K _2P 13.1(THIK-1) channel reveals a novel hydrophilic pore restriction and lipid cofactor site

1. Shatabdi Roy-Chowdhury
2. Seil Jang
3. Fayal Abderemane-Ali
4. Fiona Naughton
5. Michael Grabe
6. Daniel L. Minor

Molecular mapping and functional validation of GLP-1R cholesterol binding sites in pancreatic beta cells

1. Affiong Ika Oqua
2. Kin Chao
3. Liliane El Eid
4. Lisa Casteller
5. Billy P Baxter
6. Alba Miguéns-Gómez
7. Sebastian Barg
8. Ben Jones
9. Jorge Bernardino de la Serna
10. Sarah L Rouse
11. Alejandra Tomas

• Curated by eLife

  eLife Assessment

  The study presents a valuable finding on the role of cholesterol-binding sites on GLP-1 receptors although the clinical ramifications are unclear and not eminent at this point. Based on the detailed and persuasive responses provided by authors to the concerns raised by reviewers, the revised manuscript is improved substantially and is convincing enough in its scientific merit. The study is a good addition to the scientific community working on receptor biology and drug development for GLP-1 R.

Reviewed by eLife

Piezo1 is a mechanosensor of soft matrix viscoelasticity

1. Mariana A. G. Oliva
2. Giuseppe Ciccone
3. Jiajun Luo
4. Jonah L. Voigt
5. Patrizia Romani
6. Oana Dobre
7. Sirio Dupont
8. Massimo Vassalli
9. Manuel Salmeron-Sanchez

Lipids modulate the organization of VDAC1, the gatekeeper of mitochondria

1. Elodie Lafargue
2. Jean-Pierre Duneau
3. Nicolas Buzhinsky
4. Pamela Ornelas
5. Alexandre Ortega
6. Varun Ravishankar
7. James Sturgis
8. Ignacio Casuso
9. Lucie Bergdoll

KCNG4 Genetic Variant Linked to Migraine Prevents Expression of KCNB1

1. Gabriel Lacroix
2. Shreyas Bhat
3. Zerghona Shafia
4. Rikard Blunck

Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2

1. Eriko Koide
2. Harlan L. Pietz
3. Jean Beltran
4. Jue Chen

The ABC transporter MsbA in a dozen environments

1. Arne Moeller
2. Lea Hoffmann
3. Anika Baier
4. Lara Jorde
5. Michael Kamel
6. Jan-Hannes Schäfer
7. Kilian Schnelle
8. Alischa Scholz
9. Dmitry Shvarev
10. Jaslyn Wong
11. Kristian Parey
12. Dovile Januliene

Molecular principles of redox-coupled sodium pumping of the ancient Rnf machinery

1. Anuj Kumar
2. Jennifer Roth
3. Hyunho Kim
4. Patricia Saura
5. Stefan Bohn
6. Tristan Reif-Trauttmansdorff
7. Anja Schubert
8. Ville R. I. Kaila
9. Jan M. Schuller
10. Volker Müller

Interplay between phosphorylation and oligomerization tunes the conformational ensemble of SWEET transporters

1. Austin T. Weigle
2. Diwakar Shukla

The C-terminal activating domain promotes Panx1 channel opening

1. Erik Henze
2. Jacqueline J. Ehrlich
3. Janice L. Robertson
4. Toshimitsu Kawate

Mg2+-dependent mechanism of environmental versatility in a multidrug efflux pump

1. Benjamin Russell Lewis
2. Muhammad R. Uddin
3. Katie M. Kuo
4. Laila M.N. Shah
5. Nicola J. Harris
6. Paula J. Booth
7. Dietmar Hammerschmid
8. James C. Gumbart
9. Helen I. Zgurskaya
10. Eamonn Reading

Ethosuximide: Subunit‐ and Gβγ‐dependent blocker and reporter of allosteric changes in GIRK channels

1. Boris Shalomov
2. Theres Friesacher
3. Daniel Yakubovich
4. J. Carlo Combista
5. Haritha P. Reddy
6. Shoham Dabbah
7. Harald Bernsteiner
8. Eva‐Maria Zangerl‐Plessl
9. Anna Stary‐Weinzinger
10. Nathan Dascal

A Second Drug Binding Site in P2X3

1. Trung Thach
2. KanagaVijayan Dhanabalan
3. Prajwal Prabhakarrao Nandekar
4. Seth Stauffer
5. Iring Heisler
6. Sarah Alvarado
7. Jonathan Snyder
8. Ramaswamy Subramanian

Specificity and tunability of efflux pumps: A new role for the proton gradient?

1. Matthew Gerry
2. Duncan Kirby
3. Boian S. Alexandrov
4. Dvira Segal
5. Anton Zilman

Structure of the Ion Channel Kir7.1 and Implications for its Function in Normal and Pathophysiologic States

1. Alys Peisley
2. Ciria C. Hernandez
3. Naima S. Dahir
4. Laura Koepping
5. Ashleigh Raczkowski
6. Min Su
7. Masoud Ghamari-Langroudi
8. Xinrui Ji
9. Luis E. Gimenez
10. Roger D. Cone

Four-color single-molecule imaging system for tracking GPCR dynamics with fluorescent HiBiT peptide

1. Toshiki Yoda
2. Yasushi Sako
3. Asuka Inoue
4. Masataka Yanagawa