Godwyns26's - a lay man's list of easy-to-understand science made possible by evaluations.

A list by Godwyns Onwuchekwa

I'm a non scientist using Sciety to gather evaluations that makes the science easier for a an ordinary person to grasp. My previous list is here: https://sciety.org/lists/d64b6bba-a94e-43ad-853c-c03c6825739c
@Godwyns26

33 articlesLast updated

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  3. Modulation of Neural Networks and Symptom Correlated in Fibromyalgia: A Randomized Double-blind Factorial Explanatory Clinical Trial of Home-Based Transcranial Direct Current Stimulation

    1. Rael Lopes Alves
    2. Maxciel Zortea
    3. Paul Vicuña Serrano
    4. Vani dos Santos Laranjeira
    5. Betina Franceschini Tocchetto
    6. Leticia Ramalho
    7. Camila Fernanda da Silveira Alves
    8. Rafaela Brugnera Tomedi
    9. Rodrigo Pereira de Almeida
    10. Samara Machado Bruck
    11. Liciane Medeiros
    12. Paulo R. S. Sanches
    13. Danton P. Silva
    14. Iraci Lucena da Silva Torres
    15. Felipe Fregni
    16. Wolnei Caumo
    Appears in 1 listLatest version

  4. Cellular mechanisms underlying central sensitization in a mouse model of chronic muscle pain

    1. Yu-Ling Lin
    2. Zhu-Sen Yang
    3. Wai-Yi Wong
    4. Shih-Che Lin
    5. Shuu-Jiun Wang
    6. Shih-Pin Chen
    7. Jen-Kun Cheng
    8. Hui Lu
    9. Cheng-Chang Lien

    • Curated by eLife

      Evaluation Summary:

      This manuscript explores the role of the central amygdala (CeA) on the mechanisms underlying chronic pain. An acid-induced muscle pain (AIMP) mouse model was used. The authors report a key pro-nociception role of CeA Somatostatin (SST) expressing neurons. The central sensitization of CeA-SST neurons was blocked by pregabalin. This work also further highlights the opposing view of the roles of CeA-SST neurons compared to CeA-PKCd neurons in modulating pain-related behaviors. This work will likely have a significant impact in the field and reconciles different previous results.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife

    4 evaluationsAppears in 2 listsLatest version Latest activity

  6. Nosocomial Outbreak of SARS-CoV-2 in a “Non-COVID-19” Hospital Ward: Virus Genome Sequencing as a Key Tool to Understand Cryptic Transmission

    1. VĂ­tor Borges
    2. Joana Isidro
    3. Filipe Macedo
    4. José Neves
    5. LuĂ­s Silva
    6. Mário Paiva
    7. José Barata
    8. Judite Catarino
    9. Liliana Ciobanu
    10. SĂ­lvia Duarte
    11. LuĂ­s Vieira
    12. Raquel Guiomar
    13. JoĂŁo Paulo Gomes

    Reviewed by NCRC, ScreenIT

    2 evaluationsAppears in 5 listsLatest version Latest activity

  7. APEX-Gold: A genetically-encoded particulate marker for robust 3D electron microscopy

    1. James Rae
    2. Charles Ferguson
    3. Nicholas Ariotti
    4. Richard I. Webb
    5. Han-Hao Cheng
    6. James L. Mead
    7. Jamie Riches
    8. Dominic J.B. Hunter
    9. Nick Martel
    10. Joanne Baltos
    11. Arthur Christopoulos
    12. Nicole S. Bryce
    13. Maria Lastra Cagigas
    14. Sachini Fonseka
    15. Edna C. Hardeman
    16. Peter W. Gunning
    17. Yann Gambin
    18. Thomas Hall
    19. Robert G. Parton

    • Curated by eLife

      Summary: The manuscript by Rae et al. reports a new protocol for labeling genetically-tagged proteins of interest with heavy atom particles for visualization by electron microscopy. The optimized protocol builds on the use of the enzyme APEX2, fused to the target protein of interest. The contrast enhancement may be useful in diverse 3D EM techniques. Also, reviewers were enthusiastic about the prospects for quantitative studies, even for low-levels of endogenous expression. Semi-quantitative studies may be enabled because the new method appears to improve the proportionality of the signal such that the number of APEX2 tags in a sample correlates with the number of heavy atom particles. The apparent simplicity of the protocol raises the potential for it to become a standard in the field of EM labeling.

      Reviewer #1, Reviewer #2 and Reviewer #3 opted to reveal their name to the authors in the decision letter after review.

    Reviewed by eLife

    4 evaluationsAppears in 3 listsLatest version Latest activity

  8. Sequencing SARS-CoV-2 genomes from saliva

    1. Tara Alpert
    2. Chantal B F Vogels
    3. Mallery I Breban
    4. Mary E Petrone
    5. Anne L Wyllie
    6. Nathan D Grubaugh
    7. Joseph R Fauver

    Reviewed by ScreenIT

    1 evaluationAppears in 3 listsLatest version Latest activity

  11. A human-specific motif facilitates CARD8 inflammasome activation after HIV-1 infection

    1. Jessie Kulsuptrakul
    2. Elizabeth A Turcotte
    3. Michael Emerman
    4. Patrick S Mitchell

    • Curated by eLife

      eLife assessment

      The study shows that human inflammasome-forming sensor CARD8 contains a specific motif that allows cleavage by the proteases of HIV-1 and its direct precursor infecting chimpanzees. In comparison, CARD8 proteins from non-human primates contain changes in this motif and seem largely resistant to proteolytic activation. The results are important, and the data on the cleavage of CARD8 in HEK293T cells are convincing, while effects on inflammasome stimulation and cell death in primary viral target cells are insufficiently supported.

    Reviewed by eLife, PREreview

    6 evaluationsAppears in 3 listsLatest version Latest activity

  12. Association of close-range contact patterns with SARS-CoV-2: a household transmission study

    1. Jackie Kleynhans
    2. Lorenzo Dall'Amico
    3. Laetitia Gauvin
    4. Michele Tizzoni
    5. Lucia Maloma
    6. Sibongile Walaza
    7. Neil A Martinson
    8. Anne von Gottberg
    9. Nicole Wolter
    10. Mvuyo Makhasi
    11. Cheryl Cohen
    12. Ciro Cattuto
    13. Stefano Tempia
    14. SA-S-HTS Group

    • Curated by eLife

      eLife assessment

      This important study examines the association between SARS-CoV-2 infection and close contact among household members, measured using proximity sensors deployed after the first case was identified in the household. The authors provide solid evidence that transmission of SARS-CoV-2 within households is not dependent upon close contact, but the study suffers from a number of limitations that are fully acknowledged.

    Reviewed by eLife

    5 evaluationsAppears in 2 listsLatest version Latest activity

  13. The ER folding sensor UGGT1 acts on TAPBPR-chaperoned peptide-free MHC I

    1. Lina Sagert
    2. Christian Winter
    3. Ina Ruppert
    4. Maximilian Zehetmaier
    5. Christoph Thomas
    6. Robert Tampé

    • Curated by eLife

      eLife assessment

      This valuable study reports a complete in vitro system where different steps and direct interactions between different components of MHCI maturation can be monitored, hence leading to a better mechanistic understanding of MHC I maturation. The evidence supporting the findings is currently incomplete and would benefit from clarification of some key issues. This work will be of interest to immunologists and biochemists.

    Reviewed by eLife

    3 evaluationsAppears in 2 listsLatest version Latest activity