PREreview

Latest preprint reviews

1. Alternative designs lead to similar performance when traits and performance vary on different axes

   This article has 2 authors:

   1. Kristen M. Nolting
   2. Kent E. Holsinger

   Reviewed by PREreview

2. Age-associated sleep-wake patterns are altered with Prdm13 signaling in the dorsomedial hypothalamus and dietary restriction in mice

   This article has 16 authors:

   1. Shogo Tsuji
   2. Cynthia S Brace
   3. Ruiqing Yao
   4. Yoshitaka Tanie
   5. Hirobumi Tada
   6. Nicholas Rensing
   7. Seiya Mizuno
   8. Julio Almunia
   9. Yingyi Kong
   10. Kazuhiro Nakamura
   11. Noboru Ogiso
   12. Shinya Toyokuni
   13. Satoru Takahashi
   14. Michael Wong
   15. Shin-ichiro Imai
   16. Akiko Satoh

   Reviewed by Review Commons, PREreview

3. Quantifying the antimicrobial activity of CRISPR-Cas9-accA modified Δ B. subtilis mutants against V. harveyi and E. Coli

   This article has 1 author:

   1. Tatiana Hillman

   Reviewed by PREreview

4. Pervasive epistasis exposes intramolecular networks in adaptive enzyme evolution

   This article has 3 authors:

   1. Karol Buda
   2. Charlotte M. Miton
   3. Nobuhiko Tokuriki

   Reviewed by PREreview

5. Irgm proteins attenuate inflammatory disease in mouse models of genital Chlamydia infection

   This article has 4 authors:

   1. Jacob Dockterman
   2. Jeffrey I. Everitt
   3. Graham Wallace
   4. Jörn Coers

   Reviewed by PREreview

6. Crystal structure of the membrane (M) protein from a SARS-COV-2-related coronavirus

   This article has 4 authors:

   1. Xiaodong Wang
   2. Yuwei Yang
   3. Ziyi Sun
   4. Xiaoming Zhou

   Reviewed by PREreview

7. Structure of SARS-CoV-2 M protein in lipid nanodiscs

   This article has 6 authors:

   1. Kimberly A Dolan
   2. Mandira Dutta
   3. David M Kern
   4. Abhay Kotecha
   5. Gregory A Voth
   6. Stephen G Brohawn

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper reports the structure of the M protein of SARS-CoV-2, as determined by cryoEM. The structure is well-determined and reveals a homodimer with overall similar structure as ORF3a, another virally encoded protein. The surface charge distribution is skewed towards positive at the C-terminal domain, which suggests roles in interactions with viral N and S proteins, and possibly viral RNA. The work is of relevance to virologists, especially those studying SARS-CoV-2.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife, PREreview

8. Fat body-specific reduction of CTPS alleviates HFD-induced obesity

   This article has 5 authors:

   1. Jingnan Liu
   2. Yuanbing Zhang
   3. Qiao-Qi Wang
   4. Youfang Zhou
   5. Ji-Long Liu

   Reviewed by PREreview

9. Notch signaling regulates Akap12 expression and primary cilia length during renal tubule morphogenesis

   This article has 11 authors:

   1. Malini Mukherjee
   2. Ishara Ratnayake
   3. Madhusudhana Janga
   4. Eric Fogarty
   5. Shania Scheidt
   6. Justin Grassmeyer
   7. Jennifer deRiso
   8. Indra Chandrasekar
   9. Phil Ahrenkiel
   10. Raphael Kopan
   11. Kameswaran Surendran

   Reviewed by PREreview

10. Ataxin-7 promotes Drosophila posterior follicle cell maturation by suppressing yorkie function

    This article has 2 authors:

    1. Hammed Badmos
    2. Daimark Bennett

    Reviewed by PREreview