Latest preprint reviews

1. Large-scale characterization of drug mechanism of action using proteome-wide thermal shift assays

   This article has 8 authors:

   1. Jonathan G Van Vranken
   2. Jiaming Li
   3. Julian Mintseris
   4. Ting-Yu Wei
   5. Catherine M Sniezek
   6. Meagan Gadzuk-Shea
   7. Steven P Gygi
   8. Devin K Schweppe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study provides a valuable showcase of a workflow to perform large-scale characterization of drug mechanisms of action using proteomics in which on-target and off-targets of 166 compounds using proteome solubility analysis in living cells and cell lysates were determined. The evidence supporting the claims of the authors is solid, however, the inclusion of more replicate experiments and more statistical rigor would have strengthened the study. This will be of broad interest to medicinal chemists, toxicologists, computational biologists and biochemists.

   Reviewed by PREreview, eLife

2. Evaluating the accuracy and reliability of large language models in assisting with pediatric differential diagnoses: A multicenter diagnostic study

   This article has 4 authors:

   1. Masab A. Mansoor
   2. Andrew F. Ibrahim
   3. David J. Grindem
   4. Asad Baig

   Reviewed by PREreview

3. Benzoxazinoid-mediated microbiome feedbacks enhance Arabidopsis growth and defense

   This article has 6 authors:

   1. Katja Stengele
   2. Lea Stauber
   3. Lisa Thoenen
   4. Henry Janse van Rensburg
   5. Viola D'Adda
   6. Klaus Schlaeppi

   Reviewed by PREreview

4. Engineering ERα degraders with pleiotropic ubiquitin ligase ligands maximizes therapeutic efficacy by co-opting distinct effector ligases

   This article has 21 authors:

   1. Anna Shemorry
   2. Willem den Besten
   3. Melinda M. Mulvihill
   4. Curt J. Essenburg
   5. Nicole Blaquiere
   6. Tracy Kleinheinz
   7. Elisia Villemure
   8. Frank Peale
   9. Gauri Deshmukh
   10. Danilo Maddalo
   11. Elizabeth Levy
   12. Kebing Yu
   13. Elizabeth A. Tovar
   14. Emily Wolfrum
   15. Robert A. Blake
   16. Karthik Nagapudi
   17. William F. Forrest
   18. Steven T. Staben
   19. Carrie R. Graveel
   20. Wayne J. Fairbrother
   21. Ingrid E. Wertz

   Reviewed by PREreview

5. Modular small RNA drives the emergence of virulence traits and environmental trade-offs in Vibrio cholerae

   This article has 3 authors:

   1. Deepak Balasubramanian
   2. Cole Crist
   3. Salvador Almagro-Moreno

   Reviewed by PREreview

6. The title and authors for this article are not available from our external data provider yet:
   10.5281/zenodo.14001490

7. The title and authors for this article are not available from our external data provider yet:
   10.5281/zenodo.14012294

8. Designing Big Data Infrastructure and Modeling for Diverse Data Elements

   This article has 1 author:

   1. Muhammad Rawish Siddiqui

   Reviewed by PREreview

9. Leveraging Big Data through NoSQL Databases -Architecture Methodologies, and Strategic Applications

   This article has 1 author:

   1. Muhammad Rawish Siddiqui

   Reviewed by PREreview

10. Strategic Framework for the Use of Computation in Natural Language Processing (NLP)

    This article has 1 author:

    1. Muhammad Rawish Siddiqui

    Reviewed by PREreview