PREreview

Latest preprint reviews

1. T cells exhibit unexpectedly low discriminatory power and can respond to ultra-low affinity peptide-MHC ligands

   This article has 8 authors:

   1. Johannes Pettmann
   2. Enas Abu-Shah
   3. Mikhail Kutuzov
   4. Daniel B. Wilson
   5. Michael L. Dustin
   6. Simon J. Davis
   7. P. Anton van der Merwe
   8. Omer Dushek

   Reviewed by PREreview

2. Induction of C ₄ genes evolved through changes in cis allowing integration into ancestral C ₃ gene regulatory networks

   This article has 6 authors:

   1. Pallavi Singh
   2. Sean R. Stevenson
   3. Ivan Reyna-Llorens
   4. Gregory Reeves
   5. Tina B. Schreier
   6. Julian M. Hibberd

   Reviewed by PREreview, preLights

3. Bioorthogonal labeling of transmembrane proteins with non-canonical amino acids allows access to masked epitopes in live neurons

   This article has 10 authors:

   1. Diogo Bessa-Neto
   2. Alexander Kuhlemann
   3. Gerti Beliu
   4. Valeria Pecoraro
   5. Sören Doose
   6. Natacha Retailleau
   7. Nicolas Chevrier
   8. David Perrais
   9. Markus Sauer
   10. Daniel Choquet

   Reviewed by PREreview

4. Inhaled budesonide in the treatment of early COVID-19 (STOIC): a phase 2, open-label, randomised controlled trial

   This article has 24 authors:

   1. Sanjay Ramakrishnan
   2. Dan V Nicolau
   3. Beverly Langford
   4. Mahdi Mahdi
   5. Helen Jeffers
   6. Christine Mwasuku
   7. Karolina Krassowska
   8. Robin Fox
   9. Ian Binnian
   10. Victoria Glover
   11. Stephen Bright
   12. Christopher Butler
   13. Jennifer L Cane
   14. Andreas Halner
   15. Philippa C Matthews
   16. Louise E Donnelly
   17. Jodie L Simpson
   18. Jonathan R Baker
   19. Nabil T Fadai
   20. Stefan Peterson
   21. Thomas Bengtsson
   22. Peter J Barnes
   23. Richard E K Russell
   24. Mona Bafadhel

   Reviewed by Rapid Reviews Infectious Diseases, PREreview, ScreenIT

5. Cell wall damage attenuates root hair patterning and tissue morphogenesis mediated by the receptor kinase STRUBBELIG

   This article has 7 authors:

   1. Ajeet Chaudhary
   2. Xia Chen
   3. Barbara Leśniewska
   4. Rodion Boikine
   5. Jin Gao
   6. Sebastian Wolf
   7. Kay Schneitz

   Reviewed by PREreview

6. Extracellular Vimentin as a Target Against SARS‐CoV‐2 Host Cell Invasion

   This article has 14 authors:

   1. Łukasz Suprewicz
   2. Maxx Swoger
   3. Sarthak Gupta
   4. Ewelina Piktel
   5. Fitzroy J. Byfield
   6. Daniel V. Iwamoto
   7. Danielle Germann
   8. Joanna Reszeć
   9. Natalia Marcińczyk
   10. Robert J. Carroll
   11. Paul A. Janmey
   12. J. M. Schwarz
   13. Robert Bucki
   14. Alison E. Patteson

   Reviewed by Rapid Reviews Infectious Diseases, PREreview, ScreenIT

7. Type VI secretion system killing by commensal Neisseria is influenced by the spatial dynamics of bacteria

   This article has 7 authors:

   1. Rafael Custodio
   2. Rhian M. Ford
   3. Cara J. Ellison
   4. Guangyu Liu
   5. Gerda Mickute
   6. Christoph M. Tang
   7. Rachel M. Exley

   Reviewed by PREreview

8. HIV-1 uncoating by release of viral cDNA from capsid-like structures in the nucleus of infected cells

   This article has 10 authors:

   1. Thorsten G Müller
   2. Vojtech Zila
   3. Kyra Peters
   4. Sandra Schifferdecker
   5. Mia Stanic
   6. Bojana Lucic
   7. Vibor Laketa
   8. Marina Lusic
   9. Barbara Müller
   10. Hans-Georg Kräusslich

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors use a variety of complementary approaches to visualize and characterize events in the first half of the HIV life cycle, with some overlap between the latter studies and the recent (and cited) Zila et al. bioRxiv paper from some of the same authors. The data are generally of high quality, and many findings are in line with recent field advances indicating that reverse transcription completes in the nucleus, that intact/nearly intact cores are imported into the nucleus, and that nuclear uncoating likely occurs immediately prior to integration. The results provide the best evidence to date that intact capsids can enter the nucleus of target cells during infection, and will generally be of interest to the field, although the impact is diminished somewhat by similar recent publications from a number of other groups (including one case that used nearly identical labeling methods to follow viral complexes during infection). Issues that should be addressed include missing controls in some cases, some examples of over-interpretation and uneven citation, and the need for additional images to help bolster some of the claims. Strengths of the study include the rigorous characterization of infection using sophisticated imaging methods and, most importantly, the use of CLEM-ET to visualize viral capsids in the nucleus.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife, PREreview

9. Single-cell proteomics defines the cellular heterogeneity of localized prostate cancer

   This article has 14 authors:

   1. Laura De Vargas Roditi
   2. Andrea Jacobs
   3. Jan H. Rueschoff
   4. Pete Bankhead
   5. Stéphane Chevrier
   6. Hartland W. Jackson
   7. Thomas Hermanns
   8. Christian D. Fankhauser
   9. Cedric Poyet
   10. Felix Chun
   11. Niels J. Rupp
   12. Alexandra Tschaebunin
   13. Bernd Bodenmiller
   14. Peter J. Wild

   Reviewed by PREreview

10. Transmission of SARS-CoV-2 considering shared chairs in outpatient dialysis: a real-world case-control study

    This article has 13 authors:

    1. Ravi Thadhani
    2. Joanna Willetts
    3. Catherine Wang
    4. John Larkin
    5. Hanjie Zhang
    6. Lemuel Rivera Fuentes
    7. Len Usvyat
    8. Kathleen Belmonte
    9. Yuedong Wang
    10. Robert Kossmann
    11. Jeffrey Hymes
    12. Peter Kotanko
    13. Franklin Maddux

    Reviewed by PREreview, ScreenIT