Latest preprint reviews

  1. Rejuvenation-Responsive and Senolytic-Sensitive Muscle Stem Cells Unveiled by CD200 and CD63 in Geriatric Muscle

    This article has 13 authors:
    1. Ye Lynne Kim
    2. Young-Woo Jo
    3. Takwon Yoo
    4. Kyusang Yoo
    5. Ji-Hoon Kim
    6. Myungsun Park
    7. In-Wook Song
    8. Hyun Kim
    9. Yea-Eun Kim
    10. Sang-Hyeon Hann
    11. Jong-Eun Park
    12. Daehyun Baek
    13. Young-Yun Kong
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides valuable insights into aged muscle stem cell biology by revealing phenotypic and functional heterogeneity within the geriatric MuSC pool and proposing a VCam-low/negative subpopulation that may account for the reported decline in MuSC numbers with age. These findings have implications for understanding aging-related changes in stem cell maintenance and for improving strategies to isolate or rejuvenate aged MuSCs. However, the evidence supporting the main claims is incomplete, key analyses such as absolute MuSC quantification, fate assessment of VCam-low/negative cells, inclusion of standard aged cohorts, and validation of proposed surface markers are still needed to confirm that overall MuSC abundance is maintained and that a distinct subpopulation has been identified.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. NAD+ boosting by oral nicotinamide mononucleotide administration regulates key metabolic and immune pathways through SIRT1 dependent and independent mechanisms to mitigate diet-induced obesity and dyslipidemia in mice

    This article has 12 authors:
    1. Yasser Majeed
    2. Najeeb M Halabi
    3. Rudolf Engelke
    4. Hina Sarwath
    5. Muna N Al-Noubi
    6. Sunkyu Choi
    7. Aisha Al-Malki
    8. Maha V Agha
    9. Muneera Vakayil
    10. Lotfi Chouchane
    11. Frank Schmidt
    12. Nayef A Mazloum
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      The mechanistic basis for the potential health benefits of NAD⁺ precursors remains incompletely understood. This manuscript provides a useful assessment of the role of SIRT1 in mediating the effects of NMN in mice fed a high-fat diet. The study addresses a key question, though some of the conclusions appear only partially supported by the presented data.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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