eLife

Latest preprint reviews

1. Predominantly linear summation of metabotropic postsynaptic potentials follows coactivation of neurogliaform interneurons

   This article has 6 authors:

   1. Attila Ozsvár
   2. Gergely Komlósi
   3. Gáspár Oláh
   4. Judith Baka
   5. Gábor Molnár
   6. Gábor Tamás

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript provides quantitative information of the integration of GABA-A and GABA-B receptor inhibitory responses in cortical pyramidal neurons induced by a presynaptic GABAergic neuron type called neurogliaform cell (NGFC). Experimental and modeling data suggest that NGFCs converge onto postsynaptic neurons with sublinear summation of ionotropic GABA-A potentials and linear summation of metabotropic GABA-B potentials probably due to a preferential spatial distribution of GABA-B receptor-GIRK clusters on the dendritic spines of postsynaptic neurons. The data represent an attempt to gain insights into the logic of GABA volume transmission within cortical microcircuits.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

2. Bacterial diet affects the age-dependent decline of associative learning in Caenorhabditis elegans

   This article has 9 authors:

   1. Satoshi Higurashi
   2. Sachio Tsukada
   3. Binta Maria Aleogho
   4. Joo Hyun Park
   5. Yana Al-Hebri
   6. Masaru Tanaka
   7. Shunji Nakano
   8. Ikue Mori
   9. Kentaro Noma

   Reviewed by eLife

3. An expanding manifold in transmodal regions characterizes adolescent reconfiguration of structural connectome organization

   This article has 55 authors:

   1. Bo-yong Park
   2. Richard AI Bethlehem
   3. Casey Paquola
   4. Sara Larivière
   5. Raul Rodríguez-Cruces
   6. Reinder Vos de Wael
   7. Neuroscience in Psychiatry Network (NSPN) Consortium
   8. Edward Bullmore
   9. Raymond Dolan
   10. Ian Goodyer
   11. Peter Fonagy
   12. Peter Jones
   13. Michael Moutoussis
   14. Tobias Hauser
   15. Sharon Neufeld
   16. Rafael Romero-Garcia
   17. Michelle St Clair
   18. Petra Vértes
   19. Kirstie Whitaker
   20. Becky Inkster
   21. Gita Prabhu
   22. Cinly Ooi
   23. Umar Toseeb
   24. Barry Widmer
   25. Junaid Bhatti
   26. Laura Villis
   27. Ayesha Alrumaithi
   28. Sarah Birt
   29. Aislinn Bowler
   30. Kalia Cleridou
   31. Hina Dadabhoy
   32. Emma Davies
   33. Ashlyn Firkins
   34. Sian Granville
   35. Elizabeth Harding
   36. Alexandra Hopkins
   37. Daniel Isaacs
   38. Janchai King
   39. Danae Kokorikou
   40. Christina Maurice
   41. Cleo McIntosh
   42. Jessica Memarzia
   43. Harriet Mills
   44. Ciara O’Donnell
   45. Sara Pantaleone
   46. Jenny Scott
   47. Beatrice Kiddle
   48. Ela Polek
   49. Pasco Fearon
   50. John Suckling
   51. Anne-Laura van Harmelen
   52. Rogier Kievit
   53. Sam Chamberlain
   54. Edward T Bullmore
   55. Boris C Bernhardt

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: This manuscript describes a longitudinal study of the adolescent structural connectome. Park et al. report on an analysis of existing semi-longitudinal NSPN 2400 data to learn how the projections of high-dimensional structural connectivity patterns onto a three dimensional subspace change with age during adolescence. They employ a non-linear manifold learning algorithm (diffusion embedding), thereby linking the maturation of global structural connectivity patterns to an emerging approach in understanding brain organization through spatial gradient representations. The authors find strong effects of expansion of structural connectomes in transmodal brain regions during adolescence. They also report findings centered on the caudate and thalamus, and supplement the structural connectivity analyses with transcriptome association analyses revealing genes enriched in specific brain regions. Finally, intelligence measures are predicted from baseline structural measures.

     This is an interesting and comprehensive set of analyses on an important topic. Overall, the figures are lovely. The sensitivity analyses are particularly commendable. The paper is well written, the data are fantastic, and the analyses are interesting. Some suggestions and points for clarification (both theoretical and methodological) are below.

     Reviewer #3 opted to reveal their name to the authors in the decision letter after review.

   Reviewed by eLife

4. Adiponectin Preserves Metabolic Fitness During Aging

   This article has 18 authors:

   1. Na Li
   2. Zhuzhen Zhang
   3. Shangang Zhao
   4. Yi Zhu
   5. Christy M. Gliniak
   6. Lavanya Vishvanath
   7. Yu A. An
   8. May-yun Wang
   9. Yingfeng Deng
   10. Qingzhang Zhu
   11. Toshiharu Onodera
   12. Orhan K Oz
   13. Ruth Gordillo
   14. Rana K. Gupta
   15. Ming Liu
   16. Tamas L. Horvath
   17. Vishwa Deep Dixit
   18. Philipp E. Scherer

   Reviewed by eLife

5. Graded spikes differentially signal neurotransmitter input in cerebrospinal fluid contacting neurons of the mouse spinal cord

   This article has 8 authors:

   1. Emily Johnson
   2. Marilyn Clark
   3. Merve Oncul
   4. Andreea Pantiru
   5. Claudia MacLean
   6. Jim Deuchars
   7. Susan A. Deuchars
   8. Jamie Johnston

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The reviewers have found the topic of your study of high interest, with very intriguing findings on the different origins of calcium transients in CSFcNs.

     However, after a careful examination of your work , the reviewers have raised the following major concerns:

     1. To conclude on calcium spikes, the imaging data without electrophysiological calibration leaves too much unknown. A careful electrophysiological examination should reveal how calcium transients of different amplitude correlate with the electrical activity of the cell, calcium spikes and spontaneous PKD2L1 channel openings as described extensively in these cells, is absolutely mandatory to conclude.

     2. The manuscript shows a lack of consideration of the importance of the sensory functions and of the role of channel PKDL1 that are both well-established in CSFcNs in mice and other models. More work is necessary to relate to these critical aspects.

     3. The number of animals for juvenile and adult mice used by the authors should be clearly stated (the manuscript only refers to the total number) but also largely increased for the authors to reach robust conclusions.

     4. Overall, more rigor should be implemented throughout the entire manuscript, with a deep writing improvement and a careful inspection of figure panels (choice and fair / complete representation of the data) and more information on conditions used for experiments (promoter used, concentrations for pharmacological agents, selection of ROIs, ventral versus dorsal CSF-cNs, definition and proportion of silent cells, enrichment in the T and L type calcium channels, etc ... ).

     Reviewer #2 and Reviewer #4 opted to reveal their name to the authors in the decision letter after review.

   Reviewed by eLife

6. Metformin alleviates stress-induced cellular senescence of aging human adipose stromal cells and the ensuing adipocyte dysfunction

   This article has 12 authors:

   1. Laura Le Pelletier
   2. Matthieu Mantecon
   3. Jennifer Gorwood
   4. Martine Auclair
   5. Roberta Foresti
   6. Roberto Motterlini
   7. Mireille Laforge
   8. Michael Atlan
   9. Bruno Fève
   10. Jacqueline Capeau
   11. Claire Lagathu
   12. Veronique Bereziat

   Reviewed by eLife

7. A naturalistic environment to study visual cognition in unrestrained monkeys

   This article has 6 authors:

   1. Georgin Jacob
   2. Harish Katti
   3. Thomas Cherian
   4. Jhilik Das
   5. KA Zhivago
   6. SP Arun

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: This manuscript describes a new experimental environment for training macaque monkeys to perform behavioral tasks. Using this facility, the authors trained freely moving macaques to perform a visual "same-different" task using operant conditioning, and under voluntary head restraint. The authors demonstrate that they could obtain reliable eye-tracking data and high-performance accuracy from macaques in this facility. They also noted that subordinate macaques can learn to perform basic aspects of the task by observing their dominant conspecifics perform the task in this facility. The authors conclude that this naturalistic environment can facilitate the study of brain activity during natural and controlled behavioral tasks.

     The manuscript is broadly organized along three distinct lines of inquiry. First, the authors describe a customized living space for a small group of macaque monkeys. Second, the authors train two of these monkeys to perform a cognitive task in a purpose-built room of the living enclosure. Third, the authors describe their experience training a third monkey to complete the cognitive task.

   Reviewed by eLife

8. Collateral sensitivity associated with antibiotic resistance plasmids

   This article has 7 authors:

   1. Cristina Herencias
   2. Jerónimo Rodríguez-Beltrán
   3. Ricardo León-Sampedro
   4. Aida Alonso-del Valle
   5. Jana Palkovičová
   6. Rafael Cantón
   7. Álvaro San Millán

   Reviewed by eLife

9. Occurrence of foamy macrophages during the innate response of zebrafish to trypanosome infections

   This article has 7 authors:

   1. Sem H Jacobs
   2. Eva Dóró
   3. Ffion R Hammond
   4. Mai E Nguyen-Chi
   5. Georges Lutfalla
   6. Geert F Wiegertjes
   7. Maria Forlenza

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: This study investigates the role of the innate immune response in controlling bloodstream trypanosome infection in the zebrafish infection model recently developed by the authors. The study found that an innate immune response, characterized by controlled inflammatory response was sufficient to control infection in some individuals, while failure to control infection was associated with a strong inflammatory response characterized by expansion of foamy macrophages. The findings highlight the importance of a balanced immune response in controlling bloodstream trypanosome infections that are likely relevant to mammalian infections.

     Reviewer #1 and Reviewer #2 opted to reveal their name to the authors in the decision letter after review.

   Reviewed by eLife

10. Surprising phenotypic diversity of cancer-associated mutations of Gly 34 in the histone H3 tail

    This article has 13 authors:

    1. Brandon R Lowe
    2. Rajesh K Yadav
    3. Ryan A Henry
    4. Patrick Schreiner
    5. Atsushi Matsuda
    6. Alfonso G Fernandez
    7. David Finkelstein
    8. Margaret Campbell
    9. Satish Kallappagoudar
    10. Carolyn M Jablonowski
    11. Andrew J Andrews
    12. Yasushi Hiraoka
    13. Janet F Partridge

    Reviewed by eLife