eLife

Latest preprint reviews

1. Contributions of h- and Na+/K+ Pump Currents to the Generation of Episodic and Continuous Rhythmic Activities

   This article has 10 authors:

   1. Simon A. Sharples
   2. Jessica Parker
   3. Alex Vargas
   4. Jonathan J. Milla-Cruz
   5. Adam P. Lognon
   6. Ning Cheng
   7. Leanne Young
   8. Anchita Shonak
   9. Gennady S. Cymbalyuk
   10. Patrick J. Whelan

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: Both reviewers found that the analysis of data was too shallow and that the HCO model was insufficiently justified in the context of spinal cord CPGs. The reviewers argue that a more robust analysis including a discussion of the dynamic properties of the model (in the context of dynamic switching) was needed to support conclusions.

   Reviewed by eLife

2. A home and rescue gene drive efficiently spreads and persists in populations

   This article has 5 authors:

   1. Nikolay P. Kandul
   2. Junru Liu
   3. Jared B. Bennett
   4. John M. Marshall
   5. Omar S. Akbari

   Reviewed by eLife

3. Retinal circuits driving a non-image forming visual behavior

   This article has 9 authors:

   1. Corinne Beier
   2. Ulisse Bocchero
   3. Zhijing Zhang
   4. Nange Jin
   5. Stephen C. Massey
   6. Christophe P. Ribelayga
   7. Kirill Martemyanov
   8. Samer Hattar
   9. Johan Pahlberg

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The reviewers all appreciated the potential of the work and felt that the general approach followed was strong. The reviewers, however, raised several important concerns. Discussion among the reviewers emphasized the importance of these. Chief among these was a concern about the extent to which the paper breaks new ground in a way that will appeal to a broad audience. Specifically, several of the results reported are expected based on prior work on the retinal pathways involved, and the results that do not fit with existing knowledge were not pursued in sufficient detail. These, and several other concerns, are detailed in the individual reviews below.

   Reviewed by eLife

4. Global gradients in intertidal species richness and functional groups

   This article has 2 authors:

   1. Jakob Thyrring
   2. Lloyd S Peck

   Reviewed by eLife

5. Glycine acylation and trafficking of a new class of bacterial lipoprotein by a composite secretion system

   This article has 8 authors:

   1. Christopher Icke
   2. Freya J Hodges
   3. Karthik Pullela
   4. Samantha A McKeand
   5. Jack Alfred Bryant
   6. Adam F Cunningham
   7. Jeff A Cole
   8. Ian R Henderson

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: All three reviewers were enthusiastic about the identification and characterization of a hybrid secretion system involved in lipoprotein acylation and trafficking. We were impressed by the strength and extent of the data and the clever use of genetic, biochemical and bioinformatic approaches. At the same time, there was agreement that the conclusion that acylation is involved in CexE secretion is not fully supported. There was also consensus that overlap between this study and the 2020 PLOS Pathogen paper from Belmont-Monroy, necessitates more direct acknowledgement.

   Reviewed by eLife

6. De Novo Lipid Labeling for Comprehensive Analysis of Subcellular Distribution and Trafficking in Live Cells

   This article has 5 authors:

   1. Jun Zhang
   2. Jia Nie
   3. Haoran Sun
   4. John-Paul Andersen
   5. Yuguang Shi

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: Zhang et al. describe an interesting method to label newly synthesized lipids with fluorescent fatty acids and track their movement in cells. All reviewers agreed that this could potentially be a useful tool. However, they all raised concerns regarding the rigor of the characterization of this methodology.

   Reviewed by eLife

7. Does Self-Reassurance Reduce Neural and Self-Report Reactivity to Negative Life Events?

   This article has 4 authors:

   1. Jeffrey J. Kim
   2. James R. Doty
   3. Ross Cunnington
   4. James N. Kirby

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: Kim and colleagues present a secondary analysis of an already published imaging dataset in 40 participants going through a two-week compassion training paradigm. They show participants standardized statements that are emotional or neutral and further have participants either engage in "self-criticism" or "self-reassurance" while considering the statements. The authors report on differences in brain regions (what they refer to as "neural pain") depending on criticism or reassurance condition. Concerns with the conceptual framework, approach, and interpretation substantially dampened our enthusiasm.

   Reviewed by eLife

8. Ex vivo observation of granulocyte activity during thrombus formation

   This article has 11 authors:

   1. Daria S. Morozova
   2. Alexey A. Martyanov
   3. Sergei I. Obydennyi
   4. Julia-Jessica D. Korobkin
   5. Alexey V. Sokolov
   6. Ekaterina V. Shamova
   7. Irina V. Gorudko
   8. Anna L. Khoreva
   9. Anna Shcherbina
   10. Mikhail A. Panteleev
   11. Anastasia N. Sveshnikova

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: Specifically, the proposed model system is valuable to study ex vivo the infiltration of the growing thrombus by granulocytes using fluorescent microscopy. In addition, this system has the potential to facilitate investigations on the role of granulocytes in thrombus growth and immune-thrombosis. Granulocytes have been classified into two different types based on their DiOC6 staining pattern, namely, type A with uniform DiOC6 and type B with cluster-like DiOC6. However, it remains unclear if the staining pattern is homogeneously so clear-cut and if the type A and B granulocytes are in addition defined by their velocity. Granulocyte activation process by "priming agents" has to be validated and the rationale for using the chosen agents needs to be provided. Finally, better-defined controls for the part of the paper dedicated to the synergistic effect between granulocytes and platelets during thrombus growth are necessary. Because in the Wiskott-Aldrich syndrome (WAS) granulocyte motility as well as platelet number and function are impaired, blood from patients with WAS is not an appropriate control for this study. For example, for the control experiments, the following controls might be used in replacement of WAS blood: (1) blood from thrombocytopenic patients or platelet-depleted blood and (2) blood in which granulocyte mobility/activation is inhibited. Finally, it would be interesting to see if neutrophil extracellular traps (NETs) develop in this model system.

   Reviewed by eLife

9. Gene expression has more power for predicting in vitro cancer cell vulnerabilities than genomics

   This article has 9 authors:

   1. Joshua M. Dempster
   2. John M. Krill-Burger
   3. James M. McFarland
   4. Allison Warren
   5. Jesse S. Boehm
   6. Francisca Vazquez
   7. William C. Hahn
   8. Todd R. Golub
   9. Aviad Tsherniak

   This article has been curated by 1 group:

   • Curated by eLife

     Summary: The authors propose a new approach to the derivation of cancer signatures and compare the relative impact of gene expression data with respect to other variables, particularly SVN and CVNs. The simplicity of the idea and of the technical approach, to the point of singling out a single gene predictive value, is a positive aspect. There are also critical aspects that will require substantial revision including the underlying influence of tissue specific genes. Overall, the paper provides a good basis for the generation of specific hypotheses that can be followed by additional validation studies at the computational and/or experimental level.

   Reviewed by eLife

10. Reinstatement of Cortical Outcome Representations during Higher-Order Learning

    This article has 4 authors:

    1. Lennart Luettgau
    2. Emanuele Porcu
    3. Claus Tempelmann
    4. Gerhard Jocham

    This article has been curated by 1 group:

    • Curated by eLife

      Summary: All reviewers agreed that the neural mechanisms by which value is conferred to stimuli that were never directly paired with reinforcement is an important topic. However, individual reviewers raised questions regarding the study design and data analysis. In particular, reviewers agreed it was not clear how you could distinguish BOLD responses to CS1 and CS2 given the temporal proximity of their presentation. They also wondered whether the current results would provide enough advance beyond previous work.

    Reviewed by eLife