eLife

Latest preprint reviews

1. Whole-organism eQTL mapping at cellular resolution with single-cell sequencing

   This article has 6 authors:

   1. Eyal Ben-David
   2. James Boocock
   3. Longhua Guo
   4. Stefan Zdraljevic
   5. Joshua S. Bloom
   6. Leonid Kruglyak

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors use a pooled single cell sequencing approach to simultaneously genotype and phenotype C. elegans. This allows them to begin to query the genetic architecture of cell specific eQTLs in a multi-cellular organism.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

2. An agnostic study of associations between ABO and RhD blood group and phenome-wide disease risk

   This article has 5 authors:

   1. Torsten Dahlén
   2. Mark Clements
   3. Jingcheng Zhao
   4. Martin L Olsson
   5. Gustaf Edgren

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this manuscript, Dahlen et al. agnostically survey a large transfusion database in Sweden to investigate the association between ABO and RhD blood group and disease occurrence for a large number of clinical phenotypes. The data reported are purely epidemiological associations, with no direct insight into biological mechanism. Nonetheless, these data are a valuable resource for the research community, and offer the potential for a number of important biologic hypotheses and insights for investigation in the future.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

3. CEM500K, a large-scale heterogeneous unlabeled cellular electron microscopy image dataset for deep learning

   This article has 2 authors:

   1. Ryan Conrad
   2. Kedar Narayan

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript describes the curation of a training dataset that will be an important resource for developers of new segmentation and deep-learning algorithms for electron microscopy data. The small size of the dataset makes it easy to use, and its broad range of image modalities ensure that the model will be applicable in many situations, making it very useful for the community.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

4. Stress resets ancestral heritable small RNA responses

   This article has 4 authors:

   1. Leah Houri-Zeevi
   2. Guy Teichman
   3. Hila Gingold
   4. Oded Rechavi

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In humans, extreme stresses, such as famine, can trigger multi-generational physiological responses through altered metabolism. In C. elegans, environmental stresses, such as heat shock, can similarly promote changes in gene expression and physiology. Here, the authors convincingly show that environmental stress can alter small RNA populations in such a manner that can alter gene expression over multiple generations. The work is beginning to tease out some of the mechanisms by which non-genetic information can regulate descendants biology.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife, preLights

5. Impaired spatial learning and suppression of sharp wave ripples by cholinergic activation at the goal location

   This article has 4 authors:

   1. Przemyslaw Jarzebowski
   2. Clara S Tang
   3. Ole Paulsen
   4. Y Audrey Hay

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest for those interested in the roles of cholinergic projections from the medial septum and sharp wave-ripples on reward learning. The work provides compelling evidence showing that activation of septal cholinergic cells at reward zones suppresses sharp wave-ripples and impairs memory performance in freely behaving animals. The work extends our knowledge of the effect of medial septum cholinergic inputs on hippocampal dependent spatial memory formation.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

6. StormGraph: A graph-based algorithm for quantitative clustering analysis of diverse single-molecule localization microscopy data

   This article has 7 authors:

   1. Joshua M. Scurll
   2. Libin Abraham
   3. Da Wei Zheng
   4. Reza Tafteh
   5. Keng C. Chou
   6. Michael R. Gold
   7. Daniel Coombs

   Reviewed by eLife

7. Systemic inflammation recruits fast-acting anti-inflammatory innate myeloid progenitors from BM into lymphatics

   This article has 16 authors:

   1. Juana Serrano-Lopez
   2. Shailaja Hegde
   3. Sachin Kumar
   4. Josefina Serrano
   5. Jing Fang
   6. Ashley M. Wellendorf
   7. Paul A. Roche
   8. Yamileth Rangel
   9. Léolène J. Carrington
   10. Hartmut Geiger
   11. H. Leighton Grimes
   12. Sanjiv Luther
   13. Ivan Maillard
   14. Joaquin Sanchez-Garcia
   15. Daniel T. Starczynowski
   16. Jose A. Cancelas

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors demonstrate that acute systemic inflammation induces a new system of rapid migration of granulocyte-macrophage progenitors and committed macrophage-dendritic progenitors but not other progenitors or stem cells from BM to lymphatic capillaries. The cells appear in the lymphatics earlier than in peripheral blood. This type of trafficking is triggered by LPS administration and is anti-inflammatory.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

8. Distinct higher-order representations of natural sounds in human and ferret auditory cortex

   This article has 6 authors:

   1. Agnès Landemard
   2. Célian Bimbard
   3. Charlie Demené
   4. Shihab Shamma
   5. Sam Norman-Haignere
   6. Yves Boubenec

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Landemard et al. compare the response properties of primary vs. non-primary auditory cortex in ferrets with respect to natural and model-matched sounds, using functional ultrasound imaging. They find that responses do not differentiate between natural and model-matched sounds across ferret auditory cortex; in contrast, by drawing on previously published data in humans, the authors suggest that this is a defining distinction between human and non-human auditory cortex.

     This was found to be a very nice study and with interesting results that are applicable to the general neuroscience community. The analyses are conducted well and a wealth of results are included, including findings for individual subjects and hemispheres (in supplementary figures). Concerns involved the size of the data set (only 2 animals), and some more explanation was needed with respect to data analysis choices.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

9. Working memory gates visual input to primate prefrontal neurons

   This article has 3 authors:

   1. Behrad Noudoost
   2. Kelsey Lynne Clark
   3. Tirin Moore

   This article has been curated by 1 group:

   • Curated by eLife

     Summary:

     This is a brief paper documenting the properties of neurons in the frontal eye field (FEF), a cortical brain area traditionally thought to receive visual input and transform it internally to motor commands. The authors used extracellular recordings and electrical microstimulation in behaving non-human primates to add to this view by showing that visual input to FEF from visual area V4 appears to be gated by working -memory activity in FEF. The study was considered well done and interesting, albeit with several important concerns about the interpretation of the findings.

     Reviewer #1 opted to reveal their name to the authors in the decision letter after review.

   Reviewed by eLife

10. Erythropoietin directly remodels the clonal composition of murine hematopoietic multipotent progenitor cells

    This article has 11 authors:

    1. Almut S Eisele
    2. Jason Cosgrove
    3. Aurelie Magniez
    4. Emilie Tubeuf
    5. Sabrina Tenreira Bento
    6. Cecile Conrad
    7. Fanny Cayrac
    8. Tamar Tak
    9. Anne-Marie Lyne
    10. Jos Urbanus
    11. Leïla Perié

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This paper will be of broad interest to readers in the field of cytokine signaling, experimental hematology and clinical hematology. Erythropoietin is one of the most widely used cytokines clinically but the cells it exerts its effects on has been debated. This study has combined clonal lineage tracing and single cell sequencing to understand the cell population that responds to erythropoietin and indicates that erythropoietin acts directly on multipotent progenitors to transiently modulate their output.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife