eLife

Latest preprint reviews

1. Individual history of winning and hierarchy landscape influence stress susceptibility in mice

   This article has 6 authors:

   1. Katherine B LeClair
   2. Kenny L Chan
   3. Manuella P Kaster
   4. Lyonna F Parise
   5. Charles Joseph Burnett
   6. Scott J Russo

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This report by LeClair et al. shows the importance of considering social dominance rank and history of winning/losing rank to define susceptibility to stress in mice. It has many strengths, including an elegant experimental design, including experiments in both males and females, and carefully considering two models of social defeat in females, and an excellent writing and representation of the data.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

2. Developmental emergence of two-stage nonlinear synaptic integration in cerebellar interneurons

   This article has 9 authors:

   1. Celia Biane
   2. Florian Rückerl
   3. Therese Abrahamsson
   4. Cécile Saint-Cloment
   5. Jean Mariani
   6. Ryuichi Shigemoto
   7. David A DiGregorio
   8. Rachel M Sherrard
   9. Laurence Cathala

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Using a range of cutting-edge techniques, the authors of this manuscript explore the functional consequences of developmental changes in dendritic morphology and synapse distribution in a GABAergic interneuron. The experiments are carefully performed and represent a thorough investigation of the structural and functional changes in synaptic inputs and postsynaptic dendritic branching patterns, an important topic for both developmental neurobiologists and synaptic physiologists. The data support most conclusions, but alternative interpretations remain possible and should be further considered.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. End-of-life targeted degradation of DAF-2 insulin/IGF-1 receptor promotes longevity free from growth-related pathologies

   This article has 5 authors:

   1. Richard Venz
   2. Tina Pekec
   3. Iskra Katic
   4. Rafal Ciosk
   5. Collin Yvès Ewald

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper reports careful work using auxin-mediated degradation to manipulate the DAF-2 insulin/IGF-1 receptor in specific tissues and at different ages of the nematode C. elegans. Since its initial discovery as a gene that could dramatically alter lifespan in this organism, daf-2 has been extensively studied. The authors make excellent and thorough use of their novel reagents to successfully add important new findings to our understanding of this broadly conserved aging pathway, including a finer dissection of the spatial and temporal requirements for DAF-2 in multiple processes, such as the decision window for entering dauer arrest and that altering the levels of this protein very late in life can still have dramatic effects on lifespan. Overall the data are convincing, but the presentation and clarity of the text could be improved.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

4. Sleep-dependent upscaled excitability, saturated neuroplasticity, and modulated cognition in the human brain

   This article has 6 authors:

   1. Mohammad Ali Salehinejad
   2. Elham Ghanavati
   3. Jörg Reinders
   4. Jan G Hengstler
   5. Min-Fang Kuo
   6. Michael A Nitsche

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Sleep serves vital functions for the body and particularly the brain, and accordingly these functions are impaired by sleep deprivation, as has been repeatedly shown for different cognitive processes. However, the neural mechanisms of such effects of sleep loss are still poorly understood. This manuscript is of interest to both sleep researchers and cognitive neuroscientists looking for insights into the effects of sleep deprivation across a broad range of methods and measures. The reported studies comprehensively investigate cortical excitability and plasticity with non-invasive brain stimulation, as well as electrophysiological markers and behavior. The studies confirm and extend previous findings, stating that, in general, sleep deprivation results in higher cortical excitability as well as a negative impact on cognitive processes.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

5. Evolution of brilliant iridescent feather nanostructures

   This article has 3 authors:

   1. Klara Katarina Nordén
   2. Chad M Eliason
   3. Mary Caswell Stoddard

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Nordén et al. examine feather iridescent color diversity across bird species. Their findings show how key modifications in feather melanosomes, pivotal nanophotonic structures, underlie the brilliant colors of iridescent feathers, broadening feather color range approximately twofold. In a next step, the authors evaluate the function of feather melanosomes by performing optical modelling of nanostructure diversity, evaluating up to 4500 distinct nanostructure combinations, which are then contrasted with the observed (color) spectral data from 120 plumage regions across 80 (diverse) bird species. This meticulous integration of diverse methods across a comprehensive dataset will not only inform biologists studying structural color biodiversity, but it may also inspire engineers designing nanophotonic systems.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

6. The generation of cortical novelty responses through inhibitory plasticity

   This article has 4 authors:

   1. Auguste Schulz
   2. Christoph Miehl
   3. Michael J Berry
   4. Julijana Gjorgjieva

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper presents the results of a model for cortical plasticity and resulting increase in neuronal responses to unexpected stimuli. This is an elegant study that provides a number of interesting, experimentally testable, hypotheses and develops a prediction for a mechanism for novelty response generation. However, a number of concerns were raised about the model, including how it relates to certain experimental data, that should be addressed.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

7. Distributed coding of duration in rodent prefrontal cortex during time reproduction

   This article has 6 authors:

   1. Josephine Henke
   2. Raven Bunk
   3. Dina von Werder
   4. Stefan Häusler
   5. Virginia L Flanagin
   6. Kay Thurley

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study investigates the neural underpinnings of the bias property of timing, namely an overestimation for short and underestimation for long intervals, during an interval reproduction task in the medial prefrontal cortex of gerbils. The key novel result is that only neural populations with mixed responses, including ramping activity with linear increasing and slope-changing modulations as a function of reproduced durations, can encode the bias effect. Overall, experiment and data analysis are technically sound, and the conclusions are mostly well supported. However, the interpretation is too broad, and the manuscript would benefit of a more focused framing.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

8. Target-specific control of olfactory bulb periglomerular cells by GABAergic and cholinergic basal forebrain inputs

   This article has 1 author:

   1. Didier De Saint Jan

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study reports on the synaptic impact of basal forebrain stimulation on a population of olfactory bulb interneurons in acute mouse brain slices. The author reveals that optogenetic stimulation of GABAergic basal forebrain afferents by and large inhibits the discharge of periglomerular cells, whereas cholinergic afferents evoke a prolonged, M1 receptor-mediated depolarization and increase in firing in a subpopulation of periglomerular cells. The current study would further our understanding of the olfactory neural circuit and how different co-released neurotransmitters shape postsynaptic neuronal responses.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

9. Information transfer in mammalian glycan-based communication

   This article has 7 authors:

   1. Felix F Fuchsberger
   2. Dongyoon Kim
   3. Natalia Baranova
   4. Hanka Vrban
   5. Marten Kagelmacher
   6. Robert Wawrzinek
   7. Christoph Rademacher

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript applies the framework of information theory to lectin-glycan signaling modulating the NF-kappaB response. The paper suggests that the information transfer capacity and information flow through the signaling pathway may be affected by a combined action of two distinct receptors having different distributions across a cell population, with possible implications for the immune response. The paper can have an impact on our understanding of signaling through multiple receptors converging on the same output, and will be of interest to experts in cellular signaling, particularly those with interest in innate immune response.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

10. Selective sorting of microRNAs into exosomes by phase-separated YBX1 condensates

    This article has 3 authors:

    1. Xiao-Man Liu
    2. Liang Ma
    3. Randy Schekman

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The ribonucleoprotein YBX1 is required for sorting of miR-233 to exosomes. Here, the authors demonstrate that YBX1 undergoes liquid liquid phase separation (LLPS) both in vitro and in vivo and YBX1 droplets specifically partition miR-233 and mediate its packaging into exosomes. The authors also demonstrate a possible connection between YBX1 condensates and P-bodies during cargo sorting into EVs. Overall, this is an elegant study and with a few additional experiments to clarify the involvement of P bodies, the story will be of broad impact to those interested in LLPS and RNA packaging into exosomes.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife