eLife

Latest preprint reviews

1. Integrative transcriptomic analysis of tissue-specific metabolic crosstalk after myocardial infarction

   This article has 13 authors:

   1. Muhammad Arif
   2. Martina Klevstig
   3. Rui Benfeitas
   4. Stephen Doran
   5. Hasan Turkez
   6. Mathias Uhlén
   7. Maryam Clausen
   8. Johannes Wikström
   9. Damla Etal
   10. Cheng Zhang
   11. Malin Levin
   12. Adil Mardinoglu
   13. Jan Boren

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of considerable interest to researchers studying the interactions between metabolic responses in myocardial infarction. Ultimately increased understanding of these interactive metabolic responses could lead to exploration of new avenues of treatment.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

2. Epigenetic analysis of Paget’s disease of bone identifies differentially methylated loci that predict disease status

   This article has 4 authors:

   1. Ilhame Diboun
   2. Sachin Wani
   3. Stuart H Ralston
   4. Omar ME Albagha

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Paget disease of bone (PDB) results in focal areas of disorganized bone, leading to bone deformities and fragility. There is substantial interest in finding circulating biomarkers that might be of use for possible diagnostic applications and towards this end, these authors identified novel DNA methylation patterns in peripheral blood mononuclear cells that are able to differentiate PDB cases from controls with a high level of accuracy. This prediction model has functional relevance as these candidate methylation sites and regions are associated with osteological and immunologic processes and in the longer term, has future clinical potential.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Quantitative mapping of dense microtubule arrays in mammalian neurons

   This article has 4 authors:

   1. Eugene A Katrukha
   2. Daphne Jurriens
   3. Desiree M Salas Pastene
   4. Lukas C Kapitein

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this manuscript, Katrukha et al. use STED and Expansion Microscopy techniques to map the distribution of different microtubule populations within the dendrites of neurons, a challenging task due to the tight bundling of microtubules along neuronal processes. They are able to show that dendritic microtubules are either acetylated or tyrosinated, but rarely have both or neither of these post-translational modifications. The strength of this paper is the quality of the experiments, the thoroughness of the analyses, and most importantly the transparent and critical discussion of the limitations the authors have encountered. This manuscript is of broad interest to the cytoskeletal and neurobiology fields.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

4. Non-nucleoside reverse transcriptase inhibitor-based combination antiretroviral therapy is associated with lower cell-associated HIV RNA and DNA levels compared to protease inhibitor-based therapy

   This article has 93 authors:

   1. Alexander O Pasternak
   2. Jelmer Vroom
   3. Neeltje A Kootstra
   4. Ferdinand WNM Wit
   5. Marijn de Bruin
   6. Davide De Francesco
   7. Margreet Bakker
   8. Caroline A Sabin
   9. Alan Winston
   10. Jan M Prins
   11. Peter Reiss
   12. Ben Berkhout
   13. The Co-morBidity in Relation to Aids (COBRA) Collaboration
   14. P Reiss
   15. FWNM Wit
   16. J Schouten
   17. KW Kooij
   18. RA van Zoest
   19. BC Elsenga
   20. FR Janssen
   21. M Heidenrijk
   22. W Zikkenheiner
   23. M van der Valk
   24. NA Kootstra
   25. T Booiman
   26. AM Harskamp-Holwerda
   27. I Maurer
   28. MM Mangas Ruiz
   29. AF Girigorie
   30. J Villaudy
   31. E Frankin
   32. AO Pasternak
   33. B Berkhout
   34. T van der Kuyl
   35. P Portegies
   36. BA Schmand
   37. GJ Geurtsen
   38. JA ter Stege
   39. M Klein Twennaar
   40. CBLM Majoie
   41. MWA Caan
   42. T Su
   43. K Weijer
   44. PHLT Bisschop
   45. A Kalsbeek
   46. M Wezel
   47. I Visser
   48. HG Ruhé
   49. C Franceschi
   50. P Garagnani
   51. C Pirazzini
   52. M Capri
   53. F Dall'Olio
   54. M Chiricolo
   55. S Salvioli
   56. J Hoeijmakers
   57. J Pothof
   58. M Prins
   59. M Martens
   60. S Moll
   61. J Berkel
   62. M Totté
   63. S Kovalev
   64. M Gisslén
   65. D Fuchs
   66. H Zetterberg
   67. A Winston
   68. J Underwood
   69. L McDonald
   70. M Stott
   71. K Legg
   72. A Lovell
   73. O Erlwein
   74. N Doyle
   75. C Kingsley
   76. DJ Sharp
   77. R Leech
   78. JH Cole
   79. S Zaheri
   80. MMJ Hillebregt
   81. YMC Ruijs
   82. DP Benschop
   83. D Burger
   84. M de Graaff-Teulen
   85. G Guaraldi
   86. A Bürkle
   87. T Sindlinger
   88. M Moreno-Villanueva
   89. A Keller
   90. C Sabin
   91. D de Francesco
   92. C Libert
   93. S Dewaele

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study addresses how antiviral treatment regimens impact persistence of an HIV reservoir in individuals who are treated for a long period. The authors examine measures of viral reservoir to understand how different antiviral treatment regimens impact residual virus in HIV infection. They find that NNRTI-based treatments are associated with lower viral reservoirs and better viral suppression than PI-based regimens, suggesting they may have some advantage at reducing HIV levels long term.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

5. Evidence for a deep, distributed and dynamic code for animacy in human ventral anterior temporal cortex

   This article has 11 authors:

   1. Timothy T Rogers
   2. Christopher R Cox
   3. Qihong Lu
   4. Akihiro Shimotake
   5. Takayuki Kikuchi
   6. Takeharu Kunieda
   7. Susumu Miyamoto
   8. Ryosuke Takahashi
   9. Akio Ikeda
   10. Riki Matsumoto
   11. Matthew A Lambon Ralph

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript will be of interest to neuroscientists and psychologists interested in how semantic information is encoded in the brain. It provides a framework for a model driven comparison of semantic encoding in recurrent neural networks and neural data. Limitations in the ways the neural data are analyzed and compared to the model provide only limited support for the major claim regarding the nature of the semantic code in human anterior temporal lobe.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

6. Constructing an adult orofacial premotor atlas in Allen mouse CCF

   This article has 10 authors:

   1. Jun Takatoh
   2. Jae Hong Park
   3. Jinghao Lu
   4. Shun Li
   5. PM Thompson
   6. Bao-Xia Han
   7. Shengli Zhao
   8. David Kleinfeld
   9. Beth Friedman
   10. Fan Wang

   Reviewed by eLife

7. Targeting circPTPN12/miR-21-5p/ΔNp63α pathway as a therapeutic strategy for human endometrial fibrosis

   This article has 18 authors:

   1. Minmin Song
   2. Guangfeng Zhao
   3. Haixiang Sun
   4. Simin Yao
   5. Zhenhua Zhou
   6. Peipei Jiang
   7. Qianwen Wu
   8. Hui Zhu
   9. Huiyan Wang
   10. Chenyan Dai
   11. Jingmei Wang
   12. Ruotian Li
   13. Yun Cao
   14. Haining lv
   15. Dan Liu
   16. Jianwu Dai
   17. Yan Zhou
   18. Yali Hu

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The study by Song and colleagues explores the role of circRNAs in fibrosis of the endometrium. The paper is of interest for scientists working in the field of endometrial fibrosis and most likely can have implications for other endometrial disorders characterised by fibrotic tissues. The study unravel the molecular mechanism underlying the disease and the thorough experimental part fully support the author's claim.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

8. Rampant tooth loss across 200 million years of frog evolution

   This article has 11 authors:

   1. Daniel J Paluh
   2. Karina Riddell
   3. Catherine M Early
   4. Maggie M Hantak
   5. Gregory FM Jongsma
   6. Rachel M Keeffe
   7. Fernanda Magalhães Silva
   8. Stuart V Nielsen
   9. María Camila Vallejo-Pareja
   10. Edward L Stanley
   11. David C Blackburn

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript will find a broad audience in the fields of evolutionary and developmental biology, especially herpetology, systematics, and those interested in the evolutionary history of vertebrate teeth. The expansive dataset presented by the authors has allowed for rigorous computational analyses yielding new insight into the evolutionary history of teeth in frogs, which is a topic that has received little attention from the scientific community. The resulting data largely support the key claims of the manuscript.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

9. A phosphorylation of RIPK3 kinase initiates an intracellular apoptotic pathway that promotes prostaglandin2α-induced corpus luteum regression

   This article has 11 authors:

   1. Dianrong Li
   2. Jie Chen
   3. Jia Guo
   4. Lin Li
   5. Gaihong Cai
   6. She Chen
   7. Jia Huang
   8. Hui Yang
   9. Yinhua Zhuang
   10. Fengchao Wang
   11. Xiaodong Wang

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript is of potential interest to the field of cell death research in terms of understanding basic mechanisms and in the context of disease. The authors have used a broad range of methodologies and identified key phosphorylation sites on the protein kinase RIPK3 that determine whether cells undergo necroptotic or apoptotic cell death. The authors examine this phosphorylation event in the context of corpus luteum regression.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

10. Rapid feedback on hospital onset SARS-CoV-2 infections combining epidemiological and sequencing data

    This article has 17 authors:

    1. Oliver Stirrup
    2. Joseph Hughes
    3. Matthew Parker
    4. David G Partridge
    5. James G Shepherd
    6. James Blackstone
    7. Francesc Coll
    8. Alexander Keeley
    9. Benjamin B Lindsey
    10. Aleksandra Marek
    11. Christine Peters
    12. Joshua B Singer
    13. The COVID-19 Genomics UK (COG-UK) consortium
    14. Asif Tamuri
    15. Thushan I de Silva
    16. Emma C Thomson
    17. Judith Breuer

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The paper describes an algorithm that combines epidemiological and sequence data to provide a rapid assessment of the probability of healthcare-associated infections among hospital onset SARS-CoV-2 infections, that also may be associated with outbreak events. There is an urgent need for tools that can synthesise multiple data streams to provide real time information to healthcare professionals. It is questionable to what extent the tool presented is generalisable to medical facilities outside of the specific data rich settings considered here, or if the tool is useful for prospective analyses. This study would be of interest to specialists working in hospital infection prevention, with more limited further interest.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife, ScreenIT