eLife

Latest preprint reviews

1. m6A modifications regulate intestinal immunity and rotavirus infection

   This article has 17 authors:

   1. Anmin Wang
   2. Wanyin Tao
   3. Jiyu Tong
   4. Juanzi Gao
   5. Jinghao Wang
   6. Gaopeng Hou
   7. Chen Qian
   8. Guorong Zhang
   9. Runzhi Li
   10. Decai Wang
   11. Xingxing Ren
   12. Kaiguang Zhang
   13. Siyuan Ding
   14. Richard A Flavell
   15. Huabing Li
   16. Wen Pan
   17. Shu Zhu

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest within the field of virus infection and RNA methylation. The data in the manuscript provide novel information on RNA methylation during rotavirus infection but do not fully support the conclusion because of several technical issues and experimental design.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

2. Dopamine enhances model-free credit assignment through boosting of retrospective model-based inference

   This article has 6 authors:

   1. Lorenz Deserno
   2. Rani Moran
   3. Jochen Michely
   4. Ying Lee
   5. Peter Dayan
   6. Raymond J Dolan

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper provides behavioral and modeling evidence for the hypothesis that dopamine is involved in the interaction between distinct model-based and model-free control systems. The issue addressed is timely and clinically relevant, and will be of interest to a broad audience interested in dopamine, learning, choice and planning.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

3. ACE2 pathway regulates thermogenesis and energy metabolism

   This article has 11 authors:

   1. Xi Cao
   2. Ting-Ting Shi
   3. Chuan-Hai Zhang
   4. Wan-Zhu Jin
   5. Li-Ni Song
   6. Yi-Chen Zhang
   7. Jing-Yi Liu
   8. Fang-Yuan Yang
   9. Charles N Rotimi
   10. Aimin Xu
   11. Jin-Kui Yang

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     With a series of elegant experiments, the authors have shown that the renin-angiotensin system (RAS) plays a critical role in thermogenesis. Involvement of brown fat and mitochondrial chain open new scenarios that may be helpful to define new target pathways for the treatment of obesity and diabetes.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

4. Judgments of agency are affected by sensory noise without recruiting metacognitive processing

   This article has 3 authors:

   1. Marika Constant
   2. Roy Salomon
   3. Elisa Filevich

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is a well-designed and well-executed study on the computational mechanisms underlying judgements of agency in an action-outcome delay task. The authors report that unlike judgments of confidence, judgments of agency do not recruit metacognitive processes. This difference between agency and confidence could be an important insight, but more needs to be done to address conceptual issues associated with the definition of metacognition, and the specific features of the task and modeling approach used to obtain and interpret the findings.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

5. Task-related hemodynamic responses in human early visual cortex are modulated by task difficulty and behavioral performance

   This article has 6 authors:

   1. Charlie S Burlingham
   2. Minyoung Ryoo
   3. Zvi N Roth
   4. Saghar Mirbagheri
   5. David J Heeger
   6. Elisha P Merriam

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This work will be of general interest to those using hemodynamic imaging, such as fMRI, to study the brain. A hemodynamic signature that is modulated by arousal level changes on a trial-to-trial basis, such as those evoked by a difficult task, would both provide insight into arousal influences on cortical activity and characterize a prominent signal in hemodynamic data that is rarely considered. Overall, the data and analyses provide support for this idea, but would benefit from additional analysis, controls, and a better framework for integrating this work with the existing literature and mechanistic understanding of arousal, neural activity, and behavior.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

6. An intestinally secreted host factor promotes microsporidia invasion of C. elegans

   This article has 6 authors:

   1. Hala Tamim El Jarkass
   2. Calvin Mok
   3. Michael R Schertzberg
   4. Andrew G Fraser
   5. Emily R Troemel
   6. Aaron W Reinke

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Despite the broad impact of microsporidia on diverse animals, host factors involved in their invasion have not been characterized. The present study identifies a previously uncharacterized intestinal factor (AAIM-1) that is necessary for efficient infection of early larval stages of C. elegans. The secreted factor has a minor effect mediating resistance to pathogenic bacteria, suggesting more general impact on the susceptibility of the worm to diverse pathogens.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

7. Structural insights into recognition of chemokine receptors by Staphylococcus aureus leukotoxins

   This article has 13 authors:

   1. Paul Lambey
   2. Omolade Otun
   3. Xiaojing Cong
   4. François Hoh
   5. Luc Brunel
   6. Pascal Verdié
   7. Claire M Grison
   8. Fanny Peysson
   9. Sylvain Jeannot
   10. Thierry Durroux
   11. Cherine Bechara
   12. Sébastien Granier
   13. Cédric Leyrat

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript reports on the interaction of LukE toxin with chemokine receptors. The study is extensive and employs a wide array of tools, although further experimentation would be needed to substantiate the inferences made by the authors. The paper will be of interest to scientists interested in host-pathogen interactions as it delves into understanding the molecular mechanism and interactions of an important toxin interacting with cellular receptors.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

8. The supramolecular landscape of growing human axons

   This article has 7 authors:

   1. Patrick C. Hoffmann
   2. Stefano L. Giandomenico
   3. Iva Ganeva
   4. Michael R. Wozny
   5. Magdalena Sutcliffe
   6. Wanda Kukulski
   7. Madeline A. Lancaster

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors have elegantly combined two techniques, air-liquid interface cerebral organoid (ALI-CO) with correlative light and electron cryo-microscopy (cryo-CLEM), to study the ultrastructure of developing human axons. The technique presented is useful and the data is of high quality and well presented. With a somewhat stronger demonstration of the molecular resolution achieved and a description of how this technique can be expanded to study other organoids or cellular structures in non-neuronal cells and tissues, this paper will be of broad interest to neuroscientists and those developing cryo-electron tomography methods.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

9. Nonlinear transient amplification in recurrent neural networks with short-term plasticity

   This article has 2 authors:

   1. Yue Kris Wu
   2. Friedemann Zenke

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Networks of excitatory neurons in the mammalian cortex are capable of responding rapidly and selectively to incoming stimuli. This rapid response is believed to be due to positive feedback among excitatory cells, which necessitates a stabilizing mechanism at circuit and cellular levels. This modelling study shows how short term plasticity at synapses can stabilize the response of a recurrently connected circuit of excitatory and inhibitory cells, whereas intrinsic spike frequency adaptation is unable to stabilise network responses. These findings deepen our understanding of the various mechanisms that can stabilise circuit dynamics and will be of broad interest to neurophysiologists and theoretical neuroscientists.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

10. Learning differentially shapes prefrontal and hippocampal activity during classical conditioning

    This article has 3 authors:

    1. Jan L Klee
    2. Bryan C Souza
    3. Francesco P Battaglia

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The hippocampal CA1 area and the PFC are extensively studied in spatial navigation tasks but relatively less investigated in non-spatial, classical conditioning tasks. The different dynamics between CA1 and PFC during the trace and inter-trial interval periods identified here are insightful. Also, the ensemble reactivation during explicitly non-spatial tasks is novel and fills a critical gap in knowledge. However, the current form does not highlight these novel findings or does not make a strong case on how they contribute to learning. Furthermore, there are a number of experimental and analytical issues that need to be addressed.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife