eLife

Latest preprint reviews

1. Widespread nociceptive maps in the human neonatal somatosensory cortex

   This article has 8 authors:

   1. Laura Jones
   2. Madeleine Verriotis
   3. Robert J Cooper
   4. Maria Pureza Laudiano-Dray
   5. Mohammed Rupawala
   6. Judith Meek
   7. Lorenzo Fabrizi
   8. Maria Fitzgerald

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest to developmental neuroscientists who study the early stages of cortical maturation and specialization, particularly in the context of somatosensory and pain system development. The authors suggest that, relative to the infant touch somatotopic map, the infant nociceptive map is more widespread and poorly localised, consistent with infants' poorly directed pain behaviour. However, there are differences in the the implementation of touch and pain conditions and concerns around the analyses that limit support for this interpretation.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

2. Divergent acyl carrier protein decouples mitochondrial Fe-S cluster biogenesis from fatty acid synthesis in malaria parasites

   This article has 6 authors:

   1. Seyi Falekun
   2. Jaime Sepulveda
   3. Yasaman Jami-Alahmadi
   4. Hahnbeom Park
   5. James A Wohlschlegel
   6. Paul A Sigala

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study defines the role of a divergent mitochondrial-localized isoform of a FASII acyl carrier protein (mACP) in the malaria parasite, Plasmodium falciparum. In contrast to the situation in other eukaryotes, mACP is not involved in fatty acid biosynthesis, but is primarily involved in stabilizing proteins involved in mitochondrial Fe-S complex formation. Analysis of mACP function in these protists indicates that ACP acquired a role in Fe-S complex formation early in eukaryotic evolution and highlights additional components of the Plasmodium respiratory chain that are important for viability.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

3. Early prediction of clinical response to checkpoint inhibitor therapy in human solid tumors through mathematical modeling

   This article has 21 authors:

   1. Joseph D Butner
   2. Geoffrey V Martin
   3. Zhihui Wang
   4. Bruna Corradetti
   5. Mauro Ferrari
   6. Nestor Esnaola
   7. Caroline Chung
   8. David S Hong
   9. James W Welsh
   10. Naomi Hasegawa
   11. Elizabeth A Mittendorf
   12. Steven A Curley
   13. Shu-Hsia Chen
   14. Ping-Ying Pan
   15. Steven K Libutti
   16. Shridar Ganesan
   17. Richard L Sidman
   18. Renata Pasqualini
   19. Wadih Arap
   20. Eugene J Koay
   21. Vittorio Cristini

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this manuscript one novel model was constructed to be predictive of cancer immunotherapy based on three parameters proposed to be associated with treatment efficacy. The parameters are easy to fetch under the clinical setting, so the model is simple for application to help predict potential patients who would benefit from immunotherapy.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

4. Standardizing workflows in imaging transcriptomics with the abagen toolbox

   This article has 6 authors:

   1. Ross D Markello
   2. Aurina Arnatkeviciute
   3. Jean-Baptiste Poline
   4. Ben D Fulcher
   5. Alex Fornito
   6. Bratislav Misic

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to scientists studying the large-scale transcriptomic organization of the human brain, and in particular those who have used or plan to use the Allen Human Brain Atlas dataset. The study is well-motivated and novel. The most striking finding is the magnitude of variability that is introduced by different data-processing decisions. The open-source software described in this study is an important contribution to the field and will be of broad utility.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. Cell-type-specific responses to associative learning in the primary motor cortex

   This article has 5 authors:

   1. Candice Lee
   2. Emerson F Harkin
   3. Xuming Yin
   4. Richard Naud
   5. Simon Chen

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Using advanced live brain imaging techniques, the authors studied the activities of neurons in the primary motor cortex of mice during a classical conditional task, in which a tone is paired with water reward. They found that distinct types of neurons respond differently to the auditory cue or the reward, and the responses evolve differentially as learning proceeds. This work reveals an interesting role of the motor cortex beyond its well-recognized function in motor control, and suggests distinct functions of pyramidal neurons as well as various interneurons in reinforcement learning.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

6. Desmosomal connectomics of all somatic muscles in an annelid larva

   This article has 7 authors:

   1. Sanja Jasek
   2. Csaba Verasztó
   3. Emelie Brodrick
   4. Réza Shahidi
   5. Tom Kazimiers
   6. Alexandra Kerbl
   7. Gáspár Jékely

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is based on digital reconstruction of a serial EM stack of a larva of the annelid Platynereis and presents a complete 3D map of all desmosomes between somatic muscle cells and their attachment partners. This resource is of interest to scientists in several fields: motor control, high-resolution anatomy, and network analyses. With the first comprehensive and complete mapping of muscle-to-body connectivity through desmosomes in an annelid larva, it has the potential to close a missing link and make progress towards understanding in a "holistic" way how a complex neural circuitry controls an equally complex pattern of movement/behavior.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

7. IRAK1-dependent Regnase-1-14-3-3 complex formation controls Regnase-1-mediated mRNA decay

   This article has 10 authors:

   1. Kotaro Akaki
   2. Kosuke Ogata
   3. Yuhei Yamauchi
   4. Noriki Iwai
   5. Ka Man Tse
   6. Fabian Hia
   7. Atsushi Mochizuki
   8. Yasushi Ishihama
   9. Takashi Mino
   10. Osamu Takeuchi

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is an important study that describes a new mechanism by which Regnase-1 is inhibited upon immune activation, which mediates the efficient synthesis of inflammatory mediators whose mRNAs are normally degraded by Regnase-1. The interaction with 14-3-3 presented here was not known before. This provides an alternative mechanism by which inflammatory mRNAs are upregulated by inhibiting degradation via Regnase-1.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

8. Determinants shaping the nanoscale architecture of the mouse rod outer segment

   This article has 6 authors:

   1. Matthias Pöge
   2. Julia Mahamid
   3. Sanae S Imanishi
   4. Jürgen M Plitzko
   5. Krzysztof Palczewski
   6. Wolfgang Baumeister

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Pöge at al. present a study of the rod outer segment (ROS). These are specialised cilia of rod photoreceptor cells, essential for sensing light cues and initiating the vision process. The authors apply cryo-FIB milling to generate highly preserved rod samples and report high-quality cryo-tomographic data providing new insights into the ultrastructure of the ROS. The work reveals potential molecular scaffolds both in the lumen of the membrane stacks and on the surface of the stack providing the structural basis for ROS crucial ordered ultrastructure. The data presented here will be highly valuable for the field of phototransduction.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

9. Exposure to landscape fire smoke reduced birthweight in low- and middle-income countries: findings from a siblings-matched case-control study

   This article has 8 authors:

   1. Jiajianghui Li
   2. Tianjia Guan
   3. Qian Guo
   4. Guannan Geng
   5. Huiyu Wang
   6. Fuyu Guo
   7. Jiwei Li
   8. Tao Xue

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper reports the results of an analysis of the association between maternal exposure to landscape fire smoke during pregnancy and low birthweight of the offspring. Given the increasing number, intensity, and duration of landscape fires across the globe as well as the impact of low birthweight on public health, the manuscript will be of interest to both scientists and policymakers. The size of the study population drawn from 54 low and middle-income countries makes the paper an important contribution to the literature on the adverse health effects of biomass fire smoke.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

10. Development and genetics of red coloration in the zebrafish relative Danio albolineatus

    This article has 6 authors:

    1. Delai Huang
    2. Victor M Lewis
    3. Tarah N Foster
    4. Matthew B Toomey
    5. Joseph C Corbo
    6. David M Parichy

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      Huang et al. address an intriguing question of pigment cell diversification in vertebrates, namely what is the relationship between (yellow) xanthophores and (red) erythrophores. Their data point to a very close relationship between the two cell types, consistent with the view that they are similar cell types differing principally in the details of their pigment biochemistry. The paper will be of interest to scientists across across a range of the many disciplines within pigmentary biology, including developmental biologists, evolutionary biologists, and those who study the chemistry of pigmentation.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife