eLife

Latest preprint reviews

1. Electrocorticography is superior to subthalamic local field potentials for movement decoding in Parkinson’s disease

   This article has 9 authors:

   1. Timon Merk
   2. Victoria Peterson
   3. Witold J Lipski
   4. Benjamin Blankertz
   5. Robert S Turner
   6. Ningfei Li
   7. Andreas Horn
   8. Robert Mark Richardson
   9. Wolf-Julian Neumann

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript will be of interest to the motor neuroscience, movement disorder, human electrophysiology, and brain computer interface communities. It examines the effectiveness of signals recorded from the subthalamic nucleus (STN) and along sensorimotor regions of the cortex for decoding simple movements in patients with Parkinson's disease. Additionally, a relationship between symptom severity and decoding performance is identified. With the recent advent of implantable closed-loop stimulators for neurological conditions such as Parkinson's disease, this paper addresses current knowledge gaps that may inform both surgical and engineering considerations for optimizing these new types of therapies.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

2. The single-cell chromatin accessibility landscape in mouse perinatal testis development

   This article has 10 authors:

   1. Hoi Ching Suen
   2. Shitao Rao
   3. Alfred Chun Shui Luk
   4. Ruoyu Zhang
   5. Lele Yang
   6. Huayu Qi
   7. Hon Cheong So
   8. Robin M Hobbs
   9. Tin-lap Lee
   10. Jinyue Liao

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Liao et al. aim to improve our understanding of the genetic networks that underlie mouse male gonadogenesis and germ cell maturation during the fetal to neonatal transition. This goal was pursued by performing scATACseq on multiple timepoints, followed by definition of cell types and identification of potential transcription factors that could control the progress of differentiation. This is an exciting paper that may have far-reaching implications in the field of reproductive biology and male infertility, but additional validation is needed to confirm the newly identified cell populations.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. TMEM120A/TACAN inhibits mechanically activated PIEZO2 channels

   This article has 4 authors:

   1. John Smith Del Rosario
   2. Matthew Gabrielle
   3. Yevgen Yudin
   4. Tibor Rohacs

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript will be of interest people studying mechanosensation (particularly touch and pain sensation) and ion channels. The authors use a combination of electrophysiology and imaging to provide evidence that the force-gated ion channel Piezo2 is negatively regulation by the enzyme Tmem120A/Tacan. The results from the heterologous expression aspects of study are relatively robust and may have potential impact on the field. The physiological relevance of these findings await further investigation.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

4. Completion of neural crest cell production and emigration is regulated by retinoic-acid-dependent inhibition of BMP signaling

   This article has 2 authors:

   1. Dina Rekler
   2. Chaya Kalcheim

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript examines how retinoid acid signaling controls the timing of neural crest production in avian embryos. The authors propose that local production of retinoid acid signaling activates the expression of BMP inhibitors in the dorsal neural tube. Disruption of BMP signaling results in the termination of neural crest migration and the establishment of the definite neural plate.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

5. Comprehensive and unbiased multiparameter high-throughput screening by compaRe finds effective and subtle drug responses in AML models

   This article has 11 authors:

   1. Morteza Chalabi Hajkarim
   2. Ella Karjalainen
   3. Mikhail Osipovitch
   4. Konstantinos Dimopoulos
   5. Sandra L Gordon
   6. Francesca Ambri
   7. Kasper Dindler Rasmussen
   8. Kirsten Grønbæk
   9. Kristian Helin
   10. Krister Wennerberg
   11. Kyoung-Jae Won

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper aims to address the current gap in the efficient analysis of large-scale multiparameter flow cytometry and other datasets. The authors offer a software toolkit with an efficient algorithm for comparing numerous samples at once. The study is well presented and is relevant to single cell analysis research.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

6. Non-uniform distribution of dendritic nonlinearities differentially engages thalamostriatal and corticostriatal inputs onto cholinergic interneurons

   This article has 8 authors:

   1. Osnat Oz
   2. Lior Matityahu
   3. Aviv Mizrahi-Kliger
   4. Alexander Kaplan
   5. Noa Berkowitz
   6. Lior Tiroshi
   7. Hagai Bergman
   8. Joshua A Goldberg

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript addresses the cellular and dendritic physiology of cholinergic interneurons in the striatum. The authors use a creative integration of electrophysiology and optical methods to investigate this distinctive cell type, which is critically important at the intersection of motivated behavior and disease. They uncover a mechanism through which two separate active conductances - the hyperpolarization-activated h-current (HCN) and the persistent sodium current (NaP) - act in concert to selectively boost synaptic input from the thalamus onto proximal dendrites of cholinergic interneurons.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

7. Malaria parasites utilize pyrophosphate to fuel an essential proton pump in the ring stage and the transition to trophozoite stage

   This article has 5 authors:

   1. Omobukola Solebo
   2. Liqin Ling
   3. Jing Zhou
   4. Tian-Min Fu
   5. Hangjun Ke

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This work will be of interest to researchers seeking new ways to target malaria parasites. The work provides insight into the energy requirements of parasites during the first day of their two-day life cycle, a period during which they are significantly resistant to a wide variety of antimalarial drugs, and identifies an essential enzyme that could be targeted in early-stage parasites. The study shows this protein is necessary for normal development and growth of parasites in red blood cells.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

8. Contingency and selection in mitochondrial genome dynamics

   This article has 2 authors:

   1. Christopher J Nunn
   2. Sidhartha Goyal

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study uses long-read sequencing to investigate the origin of spontaneous petite mutants in S. cerevisiae. The results illustrate how the S. cerevisiae mitochondrial genome is prone to recombination events that lead to the formation of complex concatemers of fragments of the mitochondrial DNA that contain a high density of replication origins and, as a result, may outcompete the full mitochondrial genome. Apart from confirming existing hypotheses about the nature of petite mutants and revealing the structural diversity of rho-mitochondrial DNA, the results also allow drawing parallels to the origins of mitochondrial mutations in other organisms.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

9. CaV2.1 channel mutations causing familial hemiplegic migraine type 1 increase the susceptibility for cortical spreading depolarizations and seizures and worsen outcome after experimental traumatic brain injury

   This article has 9 authors:

   1. Nicole A Terpolilli
   2. Reinhard Dolp
   3. Kai Waehner
   4. Susanne M Schwarzmaier
   5. Elisabeth Rumbler
   6. Boyan Todorov
   7. Michel D Ferrari
   8. Arn MJM van den Maagdenberg
   9. Nikolaus Plesnila

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors demonstrate that patients carrying a gain-of-function S218L mutation in CACNA1A exhibit a gene-dosage-dependent increase in the susceptibility to cortical spreading depression (CSD), seizure activity and brain edema formation following TBI compared with wild-type (WT) mice or mice carrying the milder R192Q mutation. This paper will be of considerable interest to familial hemiplegic migraine (FHM) sufferers who experience traumatic brain injury (and their physicians), as well researchers with an interest in the spectrum and phenotypic consequences of mutations in the voltage-gated, P/Q-type Ca2+ channel, CACNA1A.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

10. A unifying mechanism governing inter-brain neural relationship during social interactions

    This article has 3 authors:

    1. Wujie Zhang
    2. Maimon C Rose
    3. Michael M Yartsev

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The phenomena of inter brain synchrony is fascinating and has been observed in a variety of situations across different mammalian species. It has also been proposed to play a critical role in certain social behaviors. Here, the authors report that brain activity across two interacting bats display not only similarities but also important differences.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

    Reviewed by eLife