eLife

Latest preprint reviews

1. Taste quality and hunger interactions in a feeding sensorimotor circuit

   This article has 5 authors:

   1. Philip K Shiu
   2. Gabriella R Sterne
   3. Stefanie Engert
   4. Barry J Dickson
   5. Kristin Scott

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript contributes to a circuit-based understanding of how sweet and bitter tastes are integrated with hunger state to drive feeding initiation in Drosophila. Anatomical, behavioral, and neuronal activity data support a multi-step pathway from sensory input to motor output. This manuscript, thus, contributes to our understanding of how multiple sensory cues are integrated with an internal state to reach a behavioral decision.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

2. Response to immune checkpoint blockade improved in pre-clinical model of breast cancer after bariatric surgery

   This article has 22 authors:

   1. Laura M Sipe
   2. Mehdi Chaib
   3. Emily B Korba
   4. Heejoon Jo
   5. Mary Camille Lovely
   6. Brittany R Counts
   7. Ubaid Tanveer
   8. Jeremiah R Holt
   9. Jared C Clements
   10. Neena A John
   11. Deidre Daria
   12. Tony N Marion
   13. Margaret S Bohm
   14. Radhika Sekhri
   15. Ajeeth K Pingili
   16. Bin Teng
   17. James A Carson
   18. D Neil Hayes
   19. Matthew J Davis
   20. Katherine L Cook
   21. Joseph F Pierre
   22. Liza Makowski

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study investigates on how weight loss by bariatric surgery or weight-matched dietary intervention impairs breast cancer growth as well as immunotherapy. This study can potentially provide some therapeutic intervention strategies on combining vertical sleeve gastrectomy and immunotherapy in treating breast cancer.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

3. Lipolysis of bone marrow adipocytes is required to fuel bone and the marrow niche during energy deficits

   This article has 16 authors:

   1. Ziru Li
   2. Emily Bowers
   3. Junxiong Zhu
   4. Hui Yu
   5. Julie Hardij
   6. Devika P Bagchi
   7. Hiroyuki Mori
   8. Kenneth T Lewis
   9. Katrina Granger
   10. Rebecca L Schill
   11. Steven M Romanelli
   12. Simin Abrishami
   13. Kurt D Hankenson
   14. Kanakadurga Singer
   15. Clifford J Rosen
   16. Ormond A MacDougald

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This is an exemplary manuscript describing the creation of a novel mouse model to study bone marrow adipocytes. The authors demonstrate that these cells play a critical role in the pathophysiology of myeloid cell lineage regeneration as well as the maintenance of bone mass and hematopoietic progenitors during times of limited energy (e.g. caloric restriction).

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

4. Successor-like representation guides the prediction of future events in human visual cortex and hippocampus

   This article has 3 authors:

   1. Matthias Ekman
   2. Sarah Kusch
   3. Floris P de Lange

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this paper, Ekman and colleagues present novel evidence, using a visual sequence task in fMRI, that the early visual cortex (V1) and the hippocampus both represent perceptual sequences in the form of a predictive "successor" representation, where the current state is represented in terms of its future (successor) states in a temporally discounted fashion. In both brain structures, there was evidence for upcoming, but not preceding steps in the sequence, and these results were found only in the temporal but not spatial domain. This study suggests that the hippocampus and V1 represent temporally structured information in a predictive, future-oriented manner.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. The acid ceramidase/ceramide axis controls parasitemia in Plasmodium yoelii-infected mice by regulating erythropoiesis

   This article has 12 authors:

   1. Anne Günther
   2. Matthias Hose
   3. Hanna Abberger
   4. Fabian Schumacher
   5. Ylva Veith
   6. Burkhard Kleuser
   7. Kai Matuschewski
   8. Karl Sebastian Lang
   9. Erich Gulbins
   10. Jan Buer
   11. Astrid M Westendorf
   12. Wiebke Hansen

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study provides evidence that murine acid ceramidase (Ac) is required for normal erythropoiesis and development of rodent malaria. The findings are of interest in understanding molecular processes involved in regulating erythropoiesis, as well as the potential to develop host-directed therapies for malarial parasites that target human reticulocytes.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

6. The role of anterior insular cortex inputs to dorsolateral striatum in binge alcohol drinking

   This article has 6 authors:

   1. David L Haggerty
   2. Braulio Munoz
   3. Taylor Pennington
   4. Gonzalo Viana Di Prisco
   5. Gregory G Grecco
   6. Brady K Atwood

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Haggerty et al. reported findings examining how changes in brain function are involved in alcohol binge drinking, with a selective focus on the synaptic and circuit alterations that occur in the anterior insular cortex inputs within the dorsolateral striatum. They show that chronic alcohol drinking produces glutamatergic synaptic adaptations and by stimulating this circuit, binge drinking could be reduced without altering either water consumption or general performance for select reinforcing, anxiogenic or locomotor behaviors. The results of this study may specifically improve our understanding of the neurocircuitry mediating a common alcohol use disorder associated behavior referred to as "front-loading" or excessive drinking during the very beginning of the session.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

7. Targeted depletion of uterine glandular Foxa2 induces embryonic diapause in mice

   This article has 7 authors:

   1. Mitsunori Matsuo
   2. Jia Yuan
   3. Yeon Sun Kim
   4. Amanda Dewar
   5. Hidetoshi Fujita
   6. Sudhansu K Dey
   7. Xiaofei Sun

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript reports the complex interactions that take place in the uterus between the endometrium and the blastocyst during and after embryonic diapause, a period of suspended animation that occurs in some mammals including the mouse, the model used here. The authors showed that one gene, Foxa2, interacts with two other genes, Msx1 and LIF, to control the success and duration of diapause. This will be of broad interest to researchers in the field of developmental biology and reproduction. It is a carefully done study, providing new information on the complex process that is diapause in which an embryo goes into suspended animation until it receives appropriate signaling from the uterine endometrial secretions to reactivate.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

8. Intergenerational adaptations to stress are evolutionarily conserved, stress-specific, and have deleterious trade-offs

   This article has 9 authors:

   1. Nicholas O Burton
   2. Alexandra Willis
   3. Kinsey Fisher
   4. Fabian Braukmann
   5. Jonathan Price
   6. Lewis Stevens
   7. L Ryan Baugh
   8. Aaron Reinke
   9. Eric A Miska

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors study intergenerational adaptation patterns in four relatively closely related nematode species, using previously established experimental procedures. Phenotypic and transcriptomic data are used to compare responses to stress triggers in the offspring generation between the species. The authors conclude that at least some of the responses are evolutionary conserved.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

9. Decreased recent adaptation at human mendelian disease genes as a possible consequence of interference between advantageous and deleterious variants

   This article has 5 authors:

   1. Chenlu Di
   2. Jesus Murga Moreno
   3. Diego F Salazar-Tortosa
   4. M Elise Lauterbur
   5. David Enard

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest for scientists studying human genetic adaptation and disease. The work improves on previous studies addressing the question of recent positive selection on genes underlying Mendelian diseases, by examining larger datasets of disease genes as well as carefully controlling for confounding factors that could result in disease genes and non-disease genes showing different patterns of genetic variation. The authors suggest that interference between strongly deleterious recessive mutations can reduce adaptation at disease genes, although this conclusion is weakened by the fact that the signal is only observed in Africa.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

10. NHE6 depletion corrects ApoE4-mediated synaptic impairments and reduces amyloid plaque load

    This article has 11 authors:

    1. Theresa Pohlkamp
    2. Xunde Xian
    3. Connie H Wong
    4. Murat S Durakoglugil
    5. Gordon Chandler Werthmann
    6. Takaomi C Saido
    7. Bret M Evers
    8. Charles L White
    9. Jade Connor
    10. Robert E Hammer
    11. Joachim Herz

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This paper is of interest to a broad range of neuroscientists, particularly those interested in ApoE biology and Alzheimer's disease (AD), as it reveals a novel mechanism that counteracts AD-linked amyloid plaque burden and synapse dysfunction in mice. Overall, the methodology is sound, sophisticated, and employs animal models that more closely mimic human diseases, and the results are interesting and compelling. Whilst the mechanistic hypothesis proposed by the authors is consistent with the data, plausible alternative explanations remain.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife