eLife

Latest preprint reviews

1. Proton-transporting heliorhodopsins from marine giant viruses

   This article has 12 authors:

   1. Shoko Hososhima
   2. Ritsu Mizutori
   3. Rei Abe-Yoshizumi
   4. Andrey Rozenberg
   5. Shunta Shigemura
   6. Alina Pushkarev
   7. Masae Konno
   8. Kota Katayama
   9. Keiichi Inoue
   10. Satoshi P Tsunoda
   11. Oded Béjà
   12. Hideki Kandori

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Hososhima et al. characterize a marine virus Heliorhodopsin as the first of its class to show ion transport activity. These bacteriorhodopsin homologs have been recently described and the present careful characterization of V2HeR3 represents an important step in the understanding of these interesting membrane proteins. Though the experiments are carried out carefully and the results, in general, support the conclusions, some experiments are needed and the interpretation of results needs to be clarified.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

2. Interacting rhythms enhance sensitivity of target detection in a fronto-parietal computational model of visual attention

   This article has 5 authors:

   1. Amélie Aussel
   2. Ian C Fiebelkorn
   3. Sabine Kastner
   4. Nancy J Kopell
   5. Benjamin Rafael Pittman-Polletta

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest to neuroscientists studying the interaction between working memory, decision making, cell types, and neural oscillations. It introduces a detailed model of different brain areas which interact giving rise to the complex pattern of oscillations that are observed during a visual attention task. Additionally, the model reproduces the phase-dependent behavioral performance observed experimentally during such a task. This provides a new level of precision in our understanding of how rhythmic attention works in the brain.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Modeling and mechanical perturbations reveal how spatially regulated anchorage gives rise to spatially distinct mechanics across the mammalian spindle

   This article has 4 authors:

   1. Pooja Suresh
   2. Vahe Galstyan
   3. Rob Phillips
   4. Sophie Dumont

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript presents a creative, unique, and well-explained theoretical analysis of the shapes adopted by chromosome-attached microtubule bundles during manipulation with glass microneedles inside dividing cells. The overall conclusion is that the bundles are laterally anchored to other structures in the mitotic apparatus within several micrometers of their chromosome-attached ends, but relatively freer at their pole-proximal ends. This interesting work should appeal broadly to cell biologists and biophysicists.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

4. A timer gene network is spatially regulated by the terminal system in the Drosophila embryo

   This article has 3 authors:

   1. Erik Clark
   2. Margherita Battistara
   3. Matthew A Benton

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Through the use of multiplexed in situ hybridization with careful embryo staging, this manuscript represents exemplary documentation of dynamic gene expression patterns in early fly development. By comparison of these patterns in various mutant combinations, a simple logical model for specification of expression is proposed. This manuscript will be of broad significance to developmental biologists interested in embryo segmentation and gene regulatory networks underpinning patterning.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

5. Rapid encoding of task regularities in the human hippocampus guides sensorimotor timing

   This article has 5 authors:

   1. Ignacio Polti
   2. Matthias Nau
   3. Raphael Kaplan
   4. Virginie van Wassenhove
   5. Christian F Doeller

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest to scientists interested in the functions of the hippocampus, as well as those in the field of sensorimotor timing. The reported data and findings point towards the possibility that the hippocampus supports specific and generalized learning of short time intervals relevant to behavior. While the conclusions are mostly supported by the evidence, further clarification of methodology as well as additional analyses and discussion would strengthen the authors' conclusions.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

6. Large protein complex interfaces have evolved to promote cotranslational assembly

   This article has 2 authors:

   1. Mihaly Badonyi
   2. Joseph A Marsh

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors use a combination of proteome-specific protein complex structures and publicly available ribosome profiling data to show that cotranslational assembly is favored by large N-terminal intermolecular interfaces. The manuscript represents an important contribution to the field of protein biosynthesis pathways by suggesting an intuitive evolutionary mechanism that can promote co-translational assembly pathways in mammalians, yeast, and bacteria.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

7. Hierarchical architecture of dopaminergic circuits enables second-order conditioning in Drosophila

   This article has 9 authors:

   1. Daichi Yamada
   2. Daniel Bushey
   3. Feng Li
   4. Karen L Hibbard
   5. Megan Sammons
   6. Jan Funke
   7. Ashok Litwin-Kumar
   8. Toshihide Hige
   9. Yoshinori Aso

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Second order conditioning is a higher form of learning where a previously conditioned stimulus (e.g. odor A by food) is used to condition the perception of another stimulus (e.g. odor B by odor A). Yamada et al. have used the fly to identify a neural circuit in the insect mushroom body underpinning second order conditioning. This work elegantly combines neural circuit mapping, electrophysiology and modeling to put forward a mechanistic model for this highly conserved form of learning.

     This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.

   Reviewed by eLife

8. Active tactile discrimination is coupled with and modulated by the cardiac cycle

   This article has 4 authors:

   1. Alejandro Galvez-Pol
   2. Pavandeep Virdee
   3. Javier Villacampa
   4. James Kilner

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The authors measured the heartbeat and touch perception while people touched a variety of surfaces. The results indicate that people's heart rates and heartbeats vary systematically according to the type of touch performed and how difficult it was to perceive the grooved surfaces. The paradigm and the results appear very interesting though the specific analyses of choice and their presentation require some improvement to make a more convincing case.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

9. Validation of a multi-ancestry polygenic risk score and age-specific risks of prostate cancer: A meta-analysis within diverse populations

   This article has 35 authors:

   1. Fei Chen
   2. Burcu F Darst
   3. Ravi K Madduri
   4. Alex A Rodriguez
   5. Xin Sheng
   6. Christopher T Rentsch
   7. Caroline Andrews
   8. Wei Tang
   9. Adam S Kibel
   10. Anna Plym
   11. Kelly Cho
   12. Mohamed Jalloh
   13. Serigne Magueye Gueye
   14. Lamine Niang
   15. Olufemi J Ogunbiyi
   16. Olufemi Popoola
   17. Akindele O Adebiyi
   18. Oseremen I Aisuodionoe-Shadrach
   19. Hafees O Ajibola
   20. Mustapha A Jamda
   21. Olabode P Oluwole
   22. Maxwell Nwegbu
   23. Ben Adusei
   24. Sunny Mante
   25. Afua Darkwa-Abrahams
   26. James E Mensah
   27. Andrew Anthony Adjei
   28. Halimatou Diop
   29. Joseph Lachance
   30. Timothy R Rebbeck
   31. Stefan Ambs
   32. J Michael Gaziano
   33. Amy C Justice
   34. David V Conti
   35. Christopher A Haiman

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is mainly for an audience of genetic epidemiologists interested in the evaluation and portability of polygenic scores. The authors show that a polygenic risk score to predict prostate cancer risk is very informative for individuals that are classified on three different ancestry categories. The authors show that the polygenic risk score can be used to predict the risk to develop prostate cancer as a function of age. This paper provides evidence that genetic information could be used to provide guidance to clinicians on when to perform screenings to detect prostate cancer in patients.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

10. Polygenic adaptation after a sudden change in environment

    This article has 2 authors:

    1. Laura Katharine Hayward
    2. Guy Sella

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This paper is an impressive and deep look at a very important problem: understanding the genetic underpinnings of evolution acting on a quantitative trait. The authors analytically study the response to an abrupt shift in phenotypic optimum, in terms of both phenotype and genetic basis (how various alleles/loci contribute to this response). The basic assumptions are classic, but the methods and findings are new (especially finite population effects) and well supported by clear analytical approximations and extensive simulation checks. The main finding is that the relative contribution of large vs moderate effect alleles changes substantially and predictably over a long-term period after the shift, even though the phenotypic changes are already undetectable over this period.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife