eLife

Latest preprint reviews

1. Non-rapid eye movement sleep determines resilience to social stress

   This article has 14 authors:

   1. Brittany J Bush
   2. Caroline Donnay
   3. Eva-Jeneé A Andrews
   4. Darielle Lewis-Sanders
   5. Cloe L Gray
   6. Zhimei Qiao
   7. Allison J Brager
   8. Hadiya Johnson
   9. Hamadi CS Brewer
   10. Sahil Sood
   11. Talib Saafir
   12. Morris Benveniste
   13. Ketema N Paul
   14. J Christopher Ehlen

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This well-written report provides new insights for neuroscientists studying sleep architecture and stress sensitivity. A particularly important conclusion is that differences in sleep architecture before chronic social defeat stress may serve as a predictive biomarker of stress resilience. Overall the work is very strong, but there are some conceptual and methodological issues that need to be addressed.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

2. Deep learning-based feature extraction for prediction and interpretation of sharp-wave ripples in the rodent hippocampus

   This article has 5 authors:

   1. Andrea Navas-Olive
   2. Rodrigo Amaducci
   3. Maria-Teresa Jurado-Parras
   4. Enrique R Sebastian
   5. Liset M de la Prida

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to the neuroscience community studying brain oscillations. It presents a new method to detect sharp-wave ripples in the hippocampus with deep learning techniques, instead of the more traditional signal processing approach. The overall detection performance improves and this technique may help identify and characterize previously undetected physiological events.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Selection and the direction of phenotypic evolution

   This article has 3 authors:

   1. François Mallard
   2. Bruno Afonso
   3. Henrique Teotónio

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a potentially important paper that takes advantage of an unusually comprehensive evolutionary genetic dataset to tease apart the relationship between genetic variation and phenotypic divergence over the ~medium term (50 generations). The questions addressed have broad relevance across evolution, conservation, and agricultural fields, and this paper will particularly appeal to evolutionary biologists. Nonetheless, the strength of evidence is incomplete for the major results and conclusions reported.

   Reviewed by eLife

4. Sweepstakes reproductive success via pervasive and recurrent selective sweeps

   This article has 4 authors:

   1. Einar Árnason
   2. Jere Koskela
   3. Katrín Halldórsdóttir
   4. Bjarki Eldon

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Analysis of molecular data from genome sequencing provides crucial information on the diversity of biological and evolutionary processes that shape genetic diversity. However, the models of genetic evolution used to make these inferences sometimes oversimplify important aspects of species biology. This study shows that accounting for high variance in reproductive success in models can better explain the genetic diversity of an extremely fecund marine species, the Atlantic cod. The manuscript is scientifically sound and provides careful statistical analyses of alternative evolutionary models. It concludes that pervasive selection, rather than demographic changes or sweepstakes reproduction, is one of the main drivers of genetic diversity in Atlantic cod.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. Spinal premotor interneurons controlling antagonistic muscles are spatially intermingled

   This article has 18 authors:

   1. Remi Ronzano
   2. Sophie Skarlatou
   3. Bianca K Barriga
   4. B Anne Bannatyne
   5. Gardave Singh Bhumbra
   6. Joshua D Foster
   7. Jeffrey D Moore
   8. Camille Lancelin
   9. Amanda M Pocratsky
   10. Mustafa Görkem Özyurt
   11. Calvin Chad Smith
   12. Andrew J Todd
   13. David J Maxwell
   14. Andrew J Murray
   15. Samuel L Pfaff
   16. Robert M Brownstone
   17. Niccolò Zampieri
   18. Marco Beato

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The experiments presented in this extensive study by Ronzano et al. are a tour-de-force investigating the spatial organization of premotor interneurons in the mouse spinal cord to re-examine the fundamental question of whether there is spatial segregation of interneurons with monosynaptic connections to motoneurons innervating functionally antagonistic (flexor and extensor) pairs of limb muscles. The authors' premotor circuit mapping experiments, involving four different collaborating laboratories applying an extensive set of complementary rabies virus-based trans-synaptic circuit tracing techniques, convincingly demonstrate complete spatial overlap among flexor and extensor premotor interneurons, contradicting previous mapping results that suggest spatial segregation. The present results revise our understanding of the spatial organization of spinal premotor circuits with fundamental implications for understanding spinal motor circuit function.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

6. Self-organized canals enable long-range directed material transport in bacterial communities

   This article has 7 authors:

   1. Ye Li
   2. Shiqi Liu
   3. Yingdan Zhang
   4. Zi Jing Seng
   5. Haoran Xu
   6. Liang Yang
   7. Yilin Wu

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The manuscript describes an interesting phenomenon of long-range transport in self-organized canal structures formed in colonies of the pathogenic bacterium Pseudomonas aeruginosa. The authors measured and analyzed the fluid flows in these open channels, revealing that it is capable of supporting high-speed transport of outer membrane vesicles and bacterial cells over centimeters. This study sheds new light on the potential amplitude of cargo exchange among bacterial communities over long distances.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

7. Enriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection

   This article has 9 authors:

   1. Amy L Seufert
   2. James W Hickman
   3. Ste K Traxler
   4. Rachael M Peterson
   5. Trent A Waugh
   6. Sydney J Lashley
   7. Natalia Shulzhenko
   8. Ruth J Napier
   9. Brooke A Napier

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this manuscript entitled "Dietary palmitic acid induces innate immune memory via ceramide production that enhances severity of acute septic shock and clearance of infection" Seufert and colleagues have investigated how saturated fatty acids increase susceptibility of the host in a murine model of LPS-mediated septic shock. Pretreatment of macrophages with palmitic acid (PA) was found to reprogram macrophages towards hyper-inflammatory phenotype, which was dependent on ceremide. Importantly, depletion of macrophages intracellular ceremide with oleic acid reversed their hyper-inflammatory phenotype. Interestingly, while PA was harmful in the LPS-acute septic shock model, it was beneficial in clearance of C. albicans in Rag-deficient mice lacking both B and T cells. While this is an exciting study, the presented data don't fully support the central hypothesis and the link with trained immunity is currently weak.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

8. Zbtb14 regulates monocyte and macrophage development through inhibiting pu.1 expression in zebrafish

   This article has 8 authors:

   1. Yun Deng
   2. Haihong Wang
   3. Xiaohui Liu
   4. Hao Yuan
   5. Jin Xu
   6. Hugues de Thé
   7. Jun Zhou
   8. Jun Zhu

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript by Deng et al., is a valuable evaluation of zbtb14 and its role in normal myelopoiesis. The authors provided convincing data supporting the role played by zbtb14 in monocyte and macrophage development and its regulation involving the modulation of PU.1 expression. The finding that a mutation in ZBTB14 exists in AML patients also implies how important this gene product is in normal human myelopoiesis.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

9. Telocytes regulate macrophages in periodontal disease

   This article has 6 authors:

   1. Jing Zhao
   2. Anahid A Birjandi
   3. Mohi Ahmed
   4. Yushi Redhead
   5. Jose Villagomez Olea
   6. Paul Sharpe

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Drs Zhao and Sharpe have highlighted the role of a relatively understudied cell type, the telocyte, in periodontitis, using a mouse model. Periodontitis is a widely occurring inflammatory disease of the gums, that will eventually progress to bone resorption and teeth that are embedded less favorably and will eventually fall out. This disease is linked to many other illnesses, such as rheumatoid arthritis, cardiac disease and even Alzheimer's disease, so more in depth knowledge is needed on cell types that play a role in the progression of the disease.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

10. Fibroblast-derived Hgf controls recruitment and expansion of muscle during morphogenesis of the mammalian diaphragm

    This article has 7 authors:

    1. Elizabeth M Sefton
    2. Mirialys Gallardo
    3. Claire E Tobin
    4. Brittany C Collins
    5. Mary P Colasanto
    6. Allyson J Merrell
    7. Gabrielle Kardon

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      Sefton et al. analyze how fibroblast-derived HGF integrates muscle and nerve development during morphogenesis of the mammalian diaphragm. The new findings are based on in-depth analyses of the development of the diaphragm muscle, and the role of Met and HGF in the process. The work is relevant for the understanding of muscle development, and congenital disease (hernia).

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

    Reviewed by eLife