eLife

Latest preprint reviews

1. Hydrogen sulfide blocks HIV rebound by maintaining mitochondrial bioenergetics and redox homeostasis

   This article has 7 authors:

   1. Virender Kumar Pal
   2. Ragini Agrawal
   3. Srabanti Rakshit
   4. Pooja Shekar
   5. Diwakar Tumkur Narasimha Murthy
   6. Annapurna Vyakarnam
   7. Amit Singh

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In the present study Pal and colleagues provide evidence that hydrogen sulfide (H2S) inhibits HIV replication and reactivation by a variety of mechanisms including inhibition of NF-kB and and recruitment of the epigenetic silencer, YY1, to the HIV promoter. They further report that H2S helps to maintaining mitochondrial bioenergetics and redox homeostasis and suggest that inclusion of an H2S donor in current ART regimens may help to achieve a functional HIV-1 cure.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

2. Homeostatic interferon-lambda response to bacterial microbiota stimulates preemptive antiviral defense within discrete pockets of intestinal epithelium

   This article has 14 authors:

   1. Jacob A Van Winkle
   2. Stefan T Peterson
   3. Elizabeth A Kennedy
   4. Michael J Wheadon
   5. Harshad Ingle
   6. Chandni Desai
   7. Rachel Rodgers
   8. David A Constant
   9. Austin P Wright
   10. Lena Li
   11. Maxim N Artyomov
   12. Sanghyun Lee
   13. Megan T Baldridge
   14. Timothy J Nice

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The paper provides information about the relative importance of the type I and type III interferon-driven gene expression and anti-viral responses, particularly focused on the role of the Intestinal microbiota to maintain background levels of type III (interferon lambda) signaling. Type III-driven gene expression is highly discontinuous in the epithelial layer and mainly at the villous tips with consequent effects on the kinetics of rotavirus model infections.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript.The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. A coarse-grained NADH redox model enables inference of subcellular metabolic fluxes from fluorescence lifetime imaging

   This article has 3 authors:

   1. Xingbo Yang
   2. Gloria Ha
   3. Daniel J Needleman

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to scientists who use imaging approaches to study cellular metabolism. It presents a new coarse-grained model for inferring mitochondrial NADH oxidation from NAD(P)H fluorescence lifetime imaging in mouse oocytes. The modeling is thoughtfully and clearly presented, but the validity of some key assumptions of the model and the overall generalizability of the method to other cell types could be strengthened.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their names with the authors.)

   Reviewed by eLife

4. Estimation and worldwide monitoring of the effective reproductive number of SARS-CoV-2

   This article has 8 authors:

   1. Jana S Huisman
   2. Jérémie Scire
   3. Daniel C Angst
   4. Jinzhou Li
   5. Richard A Neher
   6. Marloes H Maathuis
   7. Sebastian Bonhoeffer
   8. Tanja Stadler

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper presents an integrated algorithm, based on several standard techniques in infectious disease epidemiology, to estimate the real-time reproductive number and show how it has evolved in different countries during COVID-19. However, the analyses should be modelled in a more integrated fashion. Uncertainty estimation requires more work. And additional data streams should be incorporated to more reliably capture infection dynamics.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife, ScreenIT

5. Metformin abrogates pathological TNF-α-producing B cells through mTOR-dependent metabolic reprogramming in polycystic ovary syndrome

   This article has 13 authors:

   1. Na Xiao
   2. Jie Wang
   3. Ting Wang
   4. Xingliang Xiong
   5. Junyi Zhou
   6. Xian Su
   7. Jing Peng
   8. Chao Yang
   9. Xiaofeng Li
   10. Ge Lin
   11. Guangxiu Lu
   12. Fei Gong
   13. Lamei Cheng

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Overall this study confirms that TNF-α is increased in peripheral blood B cells from PCOS and metformin decreased production. The study demonstrates the potential mechanism for the increase in TNF-α and reduction due to metformin. This is demonstrated in humans as well as in a mouse model of PCOS. Overall this is a well designed study demonstrating the impact of Metformin on immune function in PCOS.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

6. Loss of Elp1 disrupts trigeminal ganglion neurodevelopment in a model of familial dysautonomia

   This article has 4 authors:

   1. Carrie E Leonard
   2. Jolie Quiros
   3. Frances Lefcort
   4. Lisa A Taneyhill

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This study uses a combination of conditional knockout mouse embryos with targeted deletion of Elp1 in neural crest cells and neuron-specific antibodies to identify the onset of neural defects associated with the trigeminal ganglion. This manuscript is of potential interest to developmental biologists studying neurodevelopment disorders and, with additional quantification and experimentation, is likely to provide important insights into the mechanisms underlying Familial Dysautonomia in the cranial sensory ganglia.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

7. Towards a unified model of naive T cell dynamics across the lifespan

   This article has 5 authors:

   1. Sanket Rane
   2. Thea Hogan
   3. Edward Lee
   4. Benedict Seddon
   5. Andrew J Yates

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of broad interest to cellular biologists and immunologists. It offers new insights into how T cell compartments are regulated in vivo defining a new perspective on how the T cell compartment is regulated to maintain immune homeostasis and afford long-term immune protection. By assessing data from a range of mouse model systems, the key deduction is that a simple hypothesis, one which notably does not have complex feedback regulation of cell numbers, provides a remarkably good explanation of the data.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

8. On the capacity of putative plant odorant-binding proteins to bind volatile plant isoprenoids

   This article has 4 authors:

   1. Deborah Giordano
   2. Angelo Facchiano
   3. Sabato D’Auria
   4. Francesco Loreto

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The chemical sensing mechanisms of plants, which are largely unknown, are a topic of broad interest. The authors hypothesise that plant chemical receptors may be transporter proteins or odorant binding proteins analogous to those found in animals. The authors have identified a list of plant proteins with possible odorant binding activity and they predict binding constants for relevant odorants. The calculated binding constants are generally very weak in comparison to known animal odorant binding proteins (i.e., would require much higher concentrations of odor for detection). The in silico investigation, while inspiring, leaves many open questions, for example whether or not there is evidence for functional analogy between plant and animal odorant binding proteins.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript.The reviewers remained anonymous to the authors.)

   Reviewed by eLife

9. Evolution of diversity in metabolic strategies

   This article has 3 authors:

   1. Rodrigo Caetano
   2. Yaroslav Ispolatov
   3. Michael Doebeli

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to scientists within community ecology. The authors present a mathematically solid analysis of how nonlinear constraints influence resource-competition models with trade-offs, with the conclusions being similar to those of previous studies in which trade-offs are not exact.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

10. The ACF chromatin-remodeling complex is essential for Polycomb repression

    This article has 5 authors:

    1. Elizabeth T Wiles
    2. Colleen C Mumford
    3. Kevin J McNaught
    4. Hideki Tanizawa
    5. Eric U Selker

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      The chromatin mark, H3K27me, is deposited by the Polycomb complex PRC2 and is associated with repressed genes. There are two important findings in this paper: 1) that the promoters of some H3K27me-repressed genes are regulated by nucleosome positioning and 2) the H3K27me repressed genes are a diverse group that can be derepressed by different mechanisms.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

    Reviewed by eLife