eLife

Latest preprint reviews

1. Alternative splicing downstream of EMT enhances phenotypic plasticity and malignant behavior in colon cancer

   This article has 8 authors:

   1. Tong Xu
   2. Mathijs Verhagen
   3. Rosalie Joosten
   4. Wenjie Sun
   5. Andrea Sacchetti
   6. Leonel Munoz Sagredo
   7. Véronique Orian-Rousseau
   8. Riccardo Fodde

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides a valuable analysis of the splicing landscape in colon cancer cells that have properties intermediate between those typically found in primary cancers ("epithelial") and those that are spreading by metastasis ("mesenchymal"). The strength of evidence provided is wide ranging and convincing, and supports current ideas that changes in the way that RNA from particular genes is processed plays a key role in cancer spread.

   Reviewed by eLife

2. Visual and motor signatures of locomotion dynamically shape a population code for feature detection in Drosophila

   This article has 4 authors:

   1. Maxwell H Turner
   2. Avery Krieger
   3. Michelle M Pang
   4. Thomas R Clandinin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript investigates how the fly visual system can encode specific features in the presence of self-generated motion. Using volumetric imaging, it explores the encoding of visual features in population activity in the Drosophila visual glomeruli - a set of visual "feature detectors". Through an elegant combination of neural imaging, visual stimulus manipulations, and behavioral analysis, it demonstrates that two different mechanisms, one based on motor signals and one based on visual input, serve to suppress local features during movements that would corrupt these features. The results of this study open up future directions to determine how motor and visual signals are integrated into visual processing at the level of neural circuits.

   Reviewed by eLife

3. Asymmetric retinal direction tuning predicts optokinetic eye movements across stimulus conditions

   This article has 2 authors:

   1. Scott C Harris
   2. Felice A Dunn

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work offers fundamental insights into how asymmetric behavioral features in optokinetic eye movements can be predicted from visual responses of direction-selective neurons in the retina. The electrophysiological experiments and model-based analyses are carefully performed and offer convincing conclusions. The presentation could improve in clarity for a stronger focus on the most important results.

   Reviewed by eLife

4. A Multi-Tissue Comparison and Molecular Characterization of Canine Organoids

   This article has 15 authors:

   1. Christopher Zdyrski
   2. Vojtech Gabriel
   3. Oscar Ospina
   4. Hannah Wickham
   5. Dipak K. Sahoo
   6. Kimberly Dao
   7. Leeann S. Aguilar Meza
   8. Abigail Ralston
   9. Leila Bedos
   10. William Bastian
   11. Sydney Honold
   12. Pablo Piñeyro
   13. Eugene F. Douglass
   14. Jonathan P. Mochel
   15. Karin Allenspach

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Organoids mimic the architecture and function of their cognate organs and have potential as replacements for animal models. Here the authors generated canine organoids from multiple adult tissues, including endometrium, lung, and pancreas, in addition to previously generated organoids from the kidney, bladder, and liver. However more methodological detail and functional characterization are required before this toolbox can be optimally utilized by wider scientific community.

   Reviewed by eLife

5. Improved ANAP incorporation and VCF analysis reveal details of P2X7 current facilitation and a limited conformational interplay between ATP binding and the intracellular ballast domain

   This article has 3 authors:

   1. Anna Durner
   2. Ellis Durner
   3. Annette Nicke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript constitutes an important foray into the conformational rearrangements throughout various domains of the notoriously difficult-to-study P2X7 receptor, with a focus on the enigmatic intracellular 'ballast' domain. This is of broad interest to those studying the role of enzymatically active intracellular domains of membrane proteins. The authors provide convincing evidence that the ballast domain is unlikely to undergo major conformational changes upon ATP-induced gating, but additional experimental support is required on the facilitation process and to elucidate the consequences exerted by intracellular factors.

   Reviewed by eLife

6. The molecular basis of socially induced egg-size plasticity in honey bees

   This article has 10 authors:

   1. Bin Han
   2. Qiaohong Wei
   3. Esmaeil Amiri
   4. Han Hu
   5. Lifeng Meng
   6. Micheline K Strand
   7. David R Tarpy
   8. Shufa Xu
   9. Jianke Li
   10. Olav Rueppell

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study investigates factors that control egg size plasticity in a social insect, the honey bee Apis mellifera. It finds that honey bee queens vary egg size in response to size of their colony, and that the gene Rho1 is involved in egg-size determination. These findings inform our understanding of maternal control over egg size, a key form of maternal investment. The work is relevant to colleagues studying reproduction and social insects.

   Reviewed by eLife

7. Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period

   This article has 20 authors:

   1. Hiba Dagher
   2. Anne-Marie Chaftari
   3. Ishwaria M Subbiah
   4. Alexandre E Malek
   5. Ying Jiang
   6. Peter Lamie
   7. Bruno Granwehr
   8. Teny John
   9. Eduardo Yepez
   10. Jovan Borjan
   11. Cielito Reyes-Gibby
   12. Mary Flores
   13. Fareed Khawaja
   14. Mala Pande
   15. Noman Ali
   16. Raniv Rojo
   17. Daniel D Karp
   18. Patrick Chaftari
   19. Ray Hachem
   20. Issam I Raad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports the results of an observational study in 312 cancer patients to assess post-acute sequelae of SARS-CoV-2 infection (PASC). Their descriptive results provide details on the type of persistent symptoms as well as their frequency among cancer patients. This is valuable information to inform clinical policies regarding disease management in cancer patients.

   Reviewed by eLife

8. Heterogeneous levels of delta-like 4 within a multinucleated niche cell maintains muscle stem cell diversity

   This article has 4 authors:

   1. Susan Eliazer
   2. Xuefeng Sun
   3. Emilie Barruet
   4. Andrew S Brack

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The premise behind this manuscript is important and timely for muscle biologists and for stem cell biologists. The identification of heterogenous distribution of factors across the myofiber is an important contribution for dissecting how muscle stem cell diversity in a tissue is achieved. However, the mechanism of action proposed by the authors will require additional experimental support.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2021.10.05.463207

10. Structure and flexibility of the yeast NuA4 histone acetyltransferase complex

    This article has 6 authors:

    1. Stefan A Zukin
    2. Matthew R Marunde
    3. Irina K Popova
    4. Katarzyna M Soczek
    5. Eva Nogales
    6. Avinash B Patel

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This manuscript provides insights into the architecture of the yeast histone acetyltransferase complex NuA4 and is of broad interest to those studying transcription and chromatin modification. The cryo-EM data are of very high quality, and enable the authors to devise a structural model that is in much better agreement with biochemical data than previously reported models. This structure represents an important puzzle piece towards a molecular understanding of chromatin modification.

    Reviewed by eLife