eLife

Latest preprint reviews

1. Structure of Geobacter OmcZ filaments suggests extracellular cytochrome polymers evolved independently multiple times

   This article has 9 authors:

   1. Fengbin Wang
   2. Chi Ho Chan
   3. Victor Suciu
   4. Khawla Mustafa
   5. Madeline Ammend
   6. Dong Si
   7. Allon I Hochbaum
   8. Edward H Egelman
   9. Daniel R Bond

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript reports the CryoEM structure of OmcZ cytochrome nanowires of Geobacter sulfurreducens, the third cytochrome nanowire of Geobacter to be structurally resolved. OmcZ differs structurally from these previously determined nanowire structures, showing a different heme chain configuration. Based on these and other differences the authors speculate about the evolutionary origin of these nanowires and the mechanism of long-range electron transport. This manuscript is an important contribution to the field of electron transfer and will be of interest to everyone working in electron transfer and filament formation and interested in their evolution.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

2. Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins

   This article has 4 authors:

   1. Megan Leander
   2. Zhuang Liu
   3. Qiang Cui
   4. Srivatsan Raman

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This article seeks to address a key question in protein biophysics: are the amino acid positions (and mutations) that influence allostery conserved across homologs of a protein family? Or is allostery implemented by a distinct set of residues that varies amongst homologs? To address this question, the authors follow an innovative approach that combines deep mutational scanning with machine learning. Significant revisions are required to clarify whether the conclusions of the study are well-supported by the data. The work is potentially highly relevant to protein engineers and biophysicists.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

3. Contrasting parental roles shape sex differences in poison frog space use but not navigational performance

   This article has 13 authors:

   1. Andrius Pašukonis
   2. Shirley Jennifer Serrano-Rojas
   3. Marie-Therese Fischer
   4. Matthias-Claudio Loretto
   5. Daniel A Shaykevich
   6. Bibiana Rojas
   7. Max Ringler
   8. Alexandre B Roland
   9. Alejandro Marcillo-Lara
   10. Eva Ringler
   11. Camilo Rodríguez
   12. Luis A Coloma
   13. Lauren A O'Connell

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of interest to organismal biologists and evolutionary scientists who study cognitive and behavioral sex differences including those with interests in the evolution of complex spatial behaviors. Using intensive field monitoring and experimentally induced navigational challenges, the authors examine two different hypotheses for sex differences in spatial ability in three species of poison frog. A rich and complex story emerges, including from the provision of evidence that is consistent with (but not necessarily yet definitively or exclusively in support of) the hypothesis that androgens may inadvertently affect spatial ability.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

4. Glucagon-like peptide-1 receptor activation stimulates PKA-mediated phosphorylation of Raptor and this contributes to the weight loss effect of liraglutide

   This article has 8 authors:

   1. Thao DV Le
   2. Dianxin Liu
   3. Gai-Linn K Besing
   4. Ritika Raghavan
   5. Blair J Ellis
   6. Ryan P Ceddia
   7. Sheila Collins
   8. Julio E Ayala

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript examines the importance of PKA-dependent mTORC1 activation for the weight-loss effects of liraglutide. The work has the potential to provide important insights, but at present is deemed preliminary as it lacks details on the mouse model and control data and needs a more in-depth analysis of the metabolic phenotype.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. Ferric reductase-related proteins mediate fungal heme acquisition

   This article has 7 authors:

   1. Udita Roy
   2. Shir Yaish
   3. Ziva Weissman
   4. Mariel Pinsky
   5. Sunanda Dey
   6. Guy Horev
   7. Daniel Kornitzer

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Iron acquisition is an essential problem for microbial growth and survival. Host defense mechanisms generally reduce iron availability and microbes often find themselves in iron poor environments. This study provides new insights into how the fungal pathogen Candida albicans obtains iron during infection.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

6. Ocean acidification increases susceptibility to sub-zero air temperatures in ecosystem engineers and limits poleward range shifts

   This article has 6 authors:

   1. Jakob Thyrring
   2. Colin D Macleod
   3. Katie E Marshall
   4. Jessica Kennedy
   5. Réjean Tremblay
   6. Christopher DG Harley

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper is of broad interest to biologists and climate modelers that study the impact of environmental stress (especially multiple stressors) on marine life. The authors show that exposure to low pH (ocean acidification) decreases the ability of two mussel species to survive freezing stress. The authors measure multiple biochemical parameters to try and identify the mechanisms underlying the change in freeze tolerance, but future work will be needed to resolve the underlying mechanism in detail.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

7. A model-based analysis of the health impacts of COVID-19 disruptions to primary cervical screening by time since last screen for current and future disruptions

   This article has 13 authors:

   1. Emily A Burger
   2. Inge MCM de Kok
   3. James F O'Mahony
   4. Matejka Rebolj
   5. Erik EL Jansen
   6. Daniel D de Bondt
   7. James Killen
   8. Sharon J Hanley
   9. Alejandra Castanon
   10. Mary Caroline Regan
   11. Jane J Kim
   12. Karen Canfell
   13. Megan A Smith

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper describes the use of three well-established mathematical models of cervical cancer to estimate the impact of COVID-19 related-delays in screening access on cervical cancer incidence and delays in diagnosis. Consistent with previous work and the known biology of cervical cancers, the findings that short delays have relatively small effects on population-level cervical cancer risk are reassuring overall, but the impact of screening interval and screening test performance suggest that existing disparities related to screening access may be exacerbated. These results should be useful for policy makers in planning responses to future pandemics or other sources of sudden restriction of screening availability.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

8. A stochastic model of hippocampal synaptic plasticity with geometrical readout of enzyme dynamics

   This article has 5 authors:

   1. Yuri Elias Rodrigues
   2. Cezar M Tigaret
   3. Hélène Marie
   4. Cian O'Donnell
   5. Romain Veltz

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper proposes a computational model that combines biologically detailed elements with more simplified components to provide a comprehensive model of synaptic plasticity. It includes the stochastic character of many of the biophysical processes and introduces a new way to readout the plasticity cascade. It is evaluated against impressively many published experimental studies of hippocampal plasticity. The paper should be of interest not only to computational neuroscience but also to the synaptic neuroscience community but will benefit from a clearer description of assumptions and weaknesses, and a clearer separation of the essential elements in this model from the less critical elements.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

9. Evolutionary gain and loss of a plant pattern-recognition receptor for HAMP recognition

   This article has 6 authors:

   1. Simon Snoeck
   2. Bradley W Abramson
   3. Anthony GK Garcia
   4. Ashley N Egan
   5. Todd P Michael
   6. Adam D Steinbrenner

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript, of interest to those studying the evolution of immunity, investigates the evolutionary history of a recently described herbivore-associated molecular pattern (HAMP) receptor, INR, which perceives the caterpillar-derived peptide HAMP, In11. The authors compare INR homologs to identify evolutionarily conserved residues and use chimeric fusion proteins to investigate specificity. The findings presented are valuable and supported by convincing experiments and analysis.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 agreed to share their name with the authors.)

   Reviewed by eLife

10. Brain atlas for glycoprotein hormone receptors at single-transcript level

    This article has 26 authors:

    1. Vitaly Ryu
    2. Anisa Gumerova
    3. Funda Korkmaz
    4. Seong Su Kang
    5. Pavel Katsel
    6. Sari Miyashita
    7. Hasni Kannangara
    8. Liam Cullen
    9. Pokman Chan
    10. TanChun Kuo
    11. Ashley Padilla
    12. Farhath Sultana
    13. Soleil A Wizman
    14. Natan Kramskiy
    15. Samir Zaidi
    16. Se-Min Kim
    17. Maria I New
    18. Clifford J Rosen
    19. Ki A Goosens
    20. Tal Frolinger
    21. Vahram Haroutunian
    22. Keqiang Ye
    23. Daria Lizneva
    24. Terry F Davies
    25. Tony Yuen
    26. Mone Zaidi

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This paper will be very interesting to the large class of neuroscientists who study functional roles of glycoprotein hormone receptors in the central nervous system. It provides detailed tissue-selective gene and receptor distributions of the three anterior pituitary hormones, and thus likely facilitates further relevant studies by other scientists.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

    Reviewed by eLife