eLife

Latest preprint reviews

1. Long COVID in cancer patients: preponderance of symptoms in majority of patients over long time period

   This article has 20 authors:

   1. Hiba Dagher
   2. Anne-Marie Chaftari
   3. Ishwaria M Subbiah
   4. Alexandre E Malek
   5. Ying Jiang
   6. Peter Lamie
   7. Bruno Granwehr
   8. Teny John
   9. Eduardo Yepez
   10. Jovan Borjan
   11. Cielito Reyes-Gibby
   12. Mary Flores
   13. Fareed Khawaja
   14. Mala Pande
   15. Noman Ali
   16. Raniv Rojo
   17. Daniel D Karp
   18. Patrick Chaftari
   19. Ray Hachem
   20. Issam I Raad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports the results of an observational study in 312 cancer patients to assess post-acute sequelae of SARS-CoV-2 infection (PASC). Their descriptive results provide details on the type of persistent symptoms as well as their frequency among cancer patients. This is valuable information to inform clinical policies regarding disease management in cancer patients.

   Reviewed by eLife

2. Heterogeneous levels of delta-like 4 within a multinucleated niche cell maintains muscle stem cell diversity

   This article has 4 authors:

   1. Susan Eliazer
   2. Xuefeng Sun
   3. Emilie Barruet
   4. Andrew S Brack

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The premise behind this manuscript is important and timely for muscle biologists and for stem cell biologists. The identification of heterogenous distribution of factors across the myofiber is an important contribution for dissecting how muscle stem cell diversity in a tissue is achieved. However, the mechanism of action proposed by the authors will require additional experimental support.

   Reviewed by eLife

3. Network segregation is associated with processing speed in the cognitively healthy oldest-old

   This article has 24 authors:

   1. Sara A Nolin
   2. Mary E Faulkner
   3. Paul Stewart
   4. Leland L Fleming
   5. Stacy Merritt
   6. Roxanne F Rezaei
   7. Pradyumna K Bharadwaj
   8. Mary Kate Franchetti
   9. David A Raichlen
   10. Cortney J Jessup
   11. Lloyd Edwards
   12. G Alex Hishaw
   13. Emily J Van Etten
   14. Theodore P Trouard
   15. David Geldmacher
   16. Virginia G Wadley
   17. Noam Alperin
   18. Eric S Porges
   19. Adam J Woods
   20. Ron A Cohen
   21. Bonnie E Levin
   22. Tatjana Rundek
   23. Gene E Alexander
   24. Kristina M Visscher

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides empirical support for how brain function at the system level, particularly network segregation, influences cognitive abilities even in the oldest-old range of human aging. The findings are potentially interesting to understand successful aging.

   Reviewed by eLife

4. Structure and flexibility of the yeast NuA4 histone acetyltransferase complex

   This article has 6 authors:

   1. Stefan A Zukin
   2. Matthew R Marunde
   3. Irina K Popova
   4. Katarzyna M Soczek
   5. Eva Nogales
   6. Avinash B Patel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides insights into the architecture of the yeast histone acetyltransferase complex NuA4 and is of broad interest to those studying transcription and chromatin modification. The cryo-EM data are of very high quality, and enable the authors to devise a structural model that is in much better agreement with biochemical data than previously reported models. This structure represents an important puzzle piece towards a molecular understanding of chromatin modification.

   Reviewed by eLife

5. Substrate stiffness impacts early biofilm formation by modulating Pseudomonas aeruginosa twitching motility

   This article has 6 authors:

   1. Sofia Gomez
   2. Lionel Bureau
   3. Karin John
   4. Elise-Noëlle Chêne
   5. Delphine Débarre
   6. Sigolene Lecuyer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study connects changes in single-cell twitching motility due to substrate stiffness to multicellular phenotypes. It is likely to have a broad impact on those studying microbiology and multicellular communities as it assesses the influence of single-cell behavior on multicellular processes. However, some of the presented data conflict with previously published literature, raising questions about the nature of these differences.

   Reviewed by eLife

6. Precise and stable edge orientation signaling by human first-order tactile neurons

   This article has 3 authors:

   1. Vaishnavi Sukumar
   2. Roland S Johansson
   3. J Andrew Pruszynski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper will be of broad interest to anyone aiming to understand the neural basis of human touch perception. This is an important paper that provides compelling evidence for peripheral tactile encoding of orientation that reflects perceptual capabilities, by using a wide range of stimulus conditions. The results will be valuable to inform both future experiments and computational investigations into the neural representation and processing of small tactile spatial features at the edge of perceptual resolvability and on the emergence of invariant representations in touch more generally.

   Reviewed by eLife

7. Patterns of interdivision time correlations reveal hidden cell cycle factors

   This article has 3 authors:

   1. Fern A Hughes
   2. Alexis R Barr
   3. Philipp Thomas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work makes an important contribution to the study of the cell cycle and inferring mechanisms by studying correlations in division timing between single cells. By treating the problem in a general way and computing over lineage trees, the authors can infer timescales in the underlying mechanism. This approach is able to detect a general role of circadian rhythms in cell cycle control. The method is validated on data sets from bacterial and mammalian cells and can suggest when additional measurements are needed to distinguish competing models. This paper is of broad interest to scientists in the fields of cell growth, cell division, and cell-cycle control.

   Reviewed by eLife

8. Macroscopic control of cell electrophysiology through ion channel expression

   This article has 5 authors:

   1. Mario García-Navarrete
   2. Merisa Avdovic
   3. Sara Pérez-Garcia
   4. Diego Ruiz Sanchis
   5. Krzysztof Wabnik

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript will be of interest to those working on non-neuronal bioelectricity, particular synthetic biologists and bioengineers. The primary contribution is the ability to leverage engineered gene circuits to control cellular membrane potential. We find issue, however, with the presentation of the data in this work as electrical communication since the synchronous behavior largely arises from external chemical stimuli.

   Reviewed by eLife

9. Homeostatic regulation through strengthening of neuronal network-correlated synaptic inputs

   This article has 3 authors:

   1. Samuel J Barnes
   2. Georg B Keller
   3. Tara Keck

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     When sensory inputs, such as vision or sound, are chronically disabled, the loss of input activity is counterbalanced by the upregulation of synaptic activity. In this study, the authors provide evidence that instead of synapses that directly represent the sensory information, synapses that show correlated intrinsic network activity are the ones that undergo the change upon sensory deprivation. This fundamental and important paper will be useful to readers in the fields of experience-dependent plasticity, sensory cortical coding, and homeostatic plasticity. While the key claims of the manuscript are well supported by the data, minor changes are suggested for clarification, including the fact that the present study has addressed homeostatic responses in adult animals rather than in juvenile animals with which homeostatic plasticity has been actively studied to date.

   Reviewed by eLife

10. An EcR probe reveals mechanisms of the ecdysone-mediated switch from repression-to-activation on target genes in the larval wing disc

    This article has 7 authors:

    1. Joanna Wardwell-Ozgo
    2. Douglas Terry
    3. Colby Schweibenz
    4. Michael Tu
    5. Ola Solimon
    6. David Schofeld
    7. Kenneth Moberg

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The manuscript by Wardwell-Ozgo and co-authors describes a thorough and interesting study that explores the mechanisms through which a hormone receptor can both repress and activate gene transcription. They have conducted an impressive number of experiments all aimed at showing that by using their new transgenic tool, and Ecdysone Receptor (EcR) ligand binding domain sponge, they can demonstrate that EcR activity is important for eliciting both types of ecdysone responses, repression, and activation, in the Drosophila wing disc and that the EcR binding partner Smarter is essential for the repressive function. The differences in expression levels have however not been quantified, which would lend greater support to their claims.

    Reviewed by eLife