eLife

Latest preprint reviews

1. Self-organized canals enable long-range directed material transport in bacterial communities

   This article has 7 authors:

   1. Ye Li
   2. Shiqi Liu
   3. Yingdan Zhang
   4. Zi Jing Seng
   5. Haoran Xu
   6. Liang Yang
   7. Yilin Wu

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The manuscript describes an interesting phenomenon of long-range transport in self-organized canal structures formed in colonies of the pathogenic bacterium Pseudomonas aeruginosa. The authors measured and analyzed the fluid flows in these open channels, revealing that it is capable of supporting high-speed transport of outer membrane vesicles and bacterial cells over centimeters. This study sheds new light on the potential amplitude of cargo exchange among bacterial communities over long distances.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

2. Enriched dietary saturated fatty acids induce trained immunity via ceramide production that enhances severity of endotoxemia and clearance of infection

   This article has 9 authors:

   1. Amy L Seufert
   2. James W Hickman
   3. Ste K Traxler
   4. Rachael M Peterson
   5. Trent A Waugh
   6. Sydney J Lashley
   7. Natalia Shulzhenko
   8. Ruth J Napier
   9. Brooke A Napier

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     In this manuscript entitled "Dietary palmitic acid induces innate immune memory via ceramide production that enhances severity of acute septic shock and clearance of infection" Seufert and colleagues have investigated how saturated fatty acids increase susceptibility of the host in a murine model of LPS-mediated septic shock. Pretreatment of macrophages with palmitic acid (PA) was found to reprogram macrophages towards hyper-inflammatory phenotype, which was dependent on ceremide. Importantly, depletion of macrophages intracellular ceremide with oleic acid reversed their hyper-inflammatory phenotype. Interestingly, while PA was harmful in the LPS-acute septic shock model, it was beneficial in clearance of C. albicans in Rag-deficient mice lacking both B and T cells. While this is an exciting study, the presented data don't fully support the central hypothesis and the link with trained immunity is currently weak.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

3. Zbtb14 regulates monocyte and macrophage development through inhibiting pu.1 expression in zebrafish

   This article has 8 authors:

   1. Yun Deng
   2. Haihong Wang
   3. Xiaohui Liu
   4. Hao Yuan
   5. Jin Xu
   6. Hugues de Thé
   7. Jun Zhou
   8. Jun Zhu

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This manuscript by Deng et al., is a valuable evaluation of zbtb14 and its role in normal myelopoiesis. The authors provided convincing data supporting the role played by zbtb14 in monocyte and macrophage development and its regulation involving the modulation of PU.1 expression. The finding that a mutation in ZBTB14 exists in AML patients also implies how important this gene product is in normal human myelopoiesis.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. The reviewers remained anonymous to the authors.)

   Reviewed by eLife

4. Telocytes regulate macrophages in periodontal disease

   This article has 6 authors:

   1. Jing Zhao
   2. Anahid A Birjandi
   3. Mohi Ahmed
   4. Yushi Redhead
   5. Jose Villagomez Olea
   6. Paul Sharpe

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Drs Zhao and Sharpe have highlighted the role of a relatively understudied cell type, the telocyte, in periodontitis, using a mouse model. Periodontitis is a widely occurring inflammatory disease of the gums, that will eventually progress to bone resorption and teeth that are embedded less favorably and will eventually fall out. This disease is linked to many other illnesses, such as rheumatoid arthritis, cardiac disease and even Alzheimer's disease, so more in depth knowledge is needed on cell types that play a role in the progression of the disease.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

5. Fibroblast-derived Hgf controls recruitment and expansion of muscle during morphogenesis of the mammalian diaphragm

   This article has 7 authors:

   1. Elizabeth M Sefton
   2. Mirialys Gallardo
   3. Claire E Tobin
   4. Brittany C Collins
   5. Mary P Colasanto
   6. Allyson J Merrell
   7. Gabrielle Kardon

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     Sefton et al. analyze how fibroblast-derived HGF integrates muscle and nerve development during morphogenesis of the mammalian diaphragm. The new findings are based on in-depth analyses of the development of the diaphragm muscle, and the role of Met and HGF in the process. The work is relevant for the understanding of muscle development, and congenital disease (hernia).

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their names with the authors.)

   Reviewed by eLife

6. The mini-IDLE 3D biomimetic culture assay enables interrogation of mechanisms governing muscle stem cell quiescence and niche repopulation

   This article has 6 authors:

   1. Erik Jacques
   2. Yinni Kuang
   3. Allison P Kann
   4. Fabien Le Grand
   5. Robert S Krauss
   6. Penney M Gilbert

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This Methods paper seeks procedures evaluating the balance between muscle cell quiescence and activation. These could well permit investigations of long-standing questions in key areas of muscle function. The latter include the regulation of adult stem cell pool size and functional heterogeneities in this, as well as regulators of muscle quiescence.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

7. Fine-grained functional parcellation maps of the infant cerebral cortex

   This article has 9 authors:

   1. Fan Wang
   2. Han Zhang
   3. Zhengwang Wu
   4. Dan Hu
   5. Zhen Zhou
   6. Jessica B Girault
   7. Li Wang
   8. Weili Lin
   9. Gang Li

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     There is currently a lack of available fine-grained infant-dedicated cortical parcellation maps. The present study fills an important gap in the research of infant brain development by generating an age-dependent functional brain parcellation from birth to 24 months, leveraging on the 1064 high-resolution longitudinal resting-state fMRI scans from 197 infants. These age-specific parcellation maps have the potential to facilitate scientific discoveries, comparisons, and validations in brain functional development. Moreover, the proposed method of establishing functional correspondences across individuals using functional gradient densities can also be applied to study brain changes across lifespan.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

   Reviewed by eLife

8. Inhibition is a prevalent mode of activity in the neocortex around awake hippocampal ripples in mice

   This article has 5 authors:

   1. Javad Karimi Abadchi
   2. Zahra Rezaei
   3. Thomas Knöpfel
   4. Bruce L McNaughton
   5. Majid H Mohajerani

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     This paper will be of interest to neurophysiologists and system neuroscientists interested in memory and more specifically in hippocampo-cortical interactions. Using a combination of imaging and electrophysiological techniques, the study characterizes neocortical activity patterns around awake hippocampal ripples. Unlike sleep ripples, cortical activity seems to be dominated by inhibition around ripples but differences between intrinsic activity and synaptic transmission highlight complex interactions in the underlying neuronal circuits and dynamics.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

9. Spinosaurus is not an aquatic dinosaur

   This article has 9 authors:

   1. Paul C Sereno
   2. Nathan Myhrvold
   3. Donald M Henderson
   4. Frank E Fish
   5. Daniel Vidal
   6. Stephanie L Baumgart
   7. Tyler M Keillor
   8. Kiersten K Formoso
   9. Lauren L Conroy

   This article has been curated by 1 group:

   • Curated by eLife

     Evaluation Summary:

     The Cretaceous dinosaur Spinosaurus has recently drawn significant attention as it was hypothesized to be the first aquatic dinosaur, using tail-powered swimming in surface waters and at depth. In a reappraisal of the "aquatic hypothesis", new lines of evidence – including the CT-based skeletal restoration of Spinosaurus and biomechanical tests – support the alternative "semi-aquatic hypothesis". This article will be of interest to vertebrate paleontologists and functional morphologists, as well as wider academic and non-academic audiences.

     (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1, Reviewer #2 and Reviewer #3 agreed to share their name with the authors.)

   Reviewed by eLife

10. An atrial fibrillation-associated regulatory region modulates cardiac Tbx5 levels and arrhythmia susceptibility

    This article has 8 authors:

    1. Fernanda M Bosada
    2. Karel van Duijvenboden
    3. Alexandra E Giovou
    4. Mathilde R Rivaud
    5. Jae-Sun Uhm
    6. Arie O Verkerk
    7. Bastiaan J Boukens
    8. Vincent M Christoffels

    This article has been curated by 1 group:

    • Curated by eLife

      Evaluation Summary:

      This manuscript presents an interesting and informative study on two regulatory elements found near atrial fibrillation-associated regions and their effect on Tbx5 expression and arrhythmia susceptibility in a mouse model. The multilevel approaches and analyses are rigorous, and the conclusions are justified by the data. Tbx5 expression may be of relevance for human atrial fibrillation and disease risk in patients, and the work is of potential interest to scientists in the fields of gene dosage, gene regulation, genetic susceptibility, genetic variants and cardiovascular biology.

      (This preprint has been reviewed by eLife. We include the public reviews from the reviewers here; the authors also receive private feedback with suggested changes to the manuscript. Reviewer #1 and Reviewer #2 agreed to share their name with the authors.)

    Reviewed by eLife