eLife

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1. Structure of human phagocyte NADPH oxidase in the resting state

   This article has 8 authors:

   1. Rui Liu
   2. Kangcheng Song
   3. Jing-Xiang Wu
   4. Xiao-Peng Geng
   5. Liming Zheng
   6. Xiaoyin Gao
   7. Hailin Peng
   8. Lei Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     NOX2 is the most well-studied member of the NADPH oxidase family, membrane enzymes that produce reactive oxygen species (ROS), and the proper function of NOX2 is critical for innate immunity against pathogens in mammals. This study reports a high-resolution structure of the NOX2-p22 complex, providing valuable information for a mechanistic understanding of NOX2 activation at the molecular level.

   Reviewed by eLife

2. EZH2/hSULF1 axis mediates receptor tyrosine kinase signaling to shape cartilage tumor progression

   This article has 12 authors:

   1. Zong-Shin Lin
   2. Chiao-Chen Chung
   3. Yu-Chia Liu
   4. Chu-Han Chang
   5. Hui-Chia Liu
   6. Yung-Yi Liang
   7. Teng-Le Huang
   8. Tsung-Ming Chen
   9. Che-Hsin Lee
   10. Chih-Hsin Tang
   11. Mien-Chie Hung
   12. Ya-Huey Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, Hung et al. address the biology and therapy of chondrosarcoma. The authors provided high-quality data that uncovered a new signaling axis, EZH2/hSULF1/c-Met, that promotes chondrosarcoma growth and progress. The authors also reported evidence showing that c-Met inhibition may be a plausible treatment option for chondrosarcoma. The findings are novel and translational and are of interest to cancer biologists and oncologists.

   Reviewed by eLife

3. Disease-modifying effects of sodium selenate in a model of drug-resistant, temporal lobe epilepsy

   This article has 16 authors:

   1. Pablo M Casillas-Espinosa
   2. Alison Anderson
   3. Anna Harutyunyan
   4. Crystal Li
   5. Jiyoon Lee
   6. Emma L Braine
   7. Rhys D Brady
   8. Mujun Sun
   9. Cheng Huang
   10. Christopher K Barlow
   11. Anup D Shah
   12. Ralf B Schittenhelm
   13. Richelle Mychasiuk
   14. Nigel C Jones
   15. Sandy R Shultz
   16. Terence J O'Brien

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Sodium selenate reduced seizures when administered after initiation of epilepsy, complementing earlier work showing efficacy if administered before initiation. The novelty of the results is not much more than the earlier study. Sodium selenate reduced phospho-tau and increased PP2A protein expression, and reversed TLE-associated telomere-shortening. However, whether these effects were critical to the reduced seizures is not clear. Finally, proteome and metabolome data from the animal model of epilepsy is discussed and provide initial insights into the effects of sodium selenate treatment on molecular pathology, however, the data are not well developed so revisions along these lines will be important so conclusions can be made.

   Reviewed by eLife

4. Rapid protein stability prediction using deep learning representations

   This article has 9 authors:

   1. Lasse M Blaabjerg
   2. Maher M Kassem
   3. Lydia L Good
   4. Nicolas Jonsson
   5. Matteo Cagiada
   6. Kristoffer E Johansson
   7. Wouter Boomsma
   8. Amelie Stein
   9. Kresten Lindorff-Larsen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment:

     Predicting the effect of mutations on protein stability is important both for protein engineering and for helping to decipher the effects of genetic and clinical mutations. The machine learning methodology introduce here is timely in view of the millions of AlphaFold model structures that are now becoming available, which could hypothetically be examined through approaches such as this one. The methodology presented is valuable, but the manuscript would benefit from a substantial amount of comparative data to provide more compelling evidence for the validity of the methods.

   Reviewed by eLife

5. Single amino acid residue mediates reciprocal specificity in two mosquito odorant receptors

   This article has 5 authors:

   1. Flavia P Franco
   2. Pingxi Xu
   3. Brandon J Harris
   4. Vladimir Yarov-Yarovoy
   5. Walter S Leal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript addresses the mechanism of ligand specificity of odorant receptors (OR) through mutational analyses and structure prediction. The authors identify a single amino acid substitution that switches ligand specificity between two olfactory receptors. Obtaining structures of OR complexes has been challenging, so such an approach is valuable and will be of interest to scientists within the fields of chemical ecology and sensory neuroscience.

   Reviewed by eLife

6. Host-microbiome metabolism of a plant toxin in bees

   This article has 7 authors:

   1. Erick VS Motta
   2. Alejandra Gage
   3. Thomas E Smith
   4. Kristin J Blake
   5. Waldan K Kwong
   6. Ian M Riddington
   7. Nancy Moran

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript makes an important contribution to understanding the roles of the bee host and microbiome in degrading amygdalin, a dietary secondary metabolite. Several bacterial strains and their enzymes responsible for the deglycosylation of amygdalin are identified. Conclusions are reached convincingly through a comprehensive combination of in vitro and in vivo experiments including gene-expression analysis, proteomics, HPLC-MS, and the use of recombinant E. coli to test enzyme function. As the consequences of microbial-derived amygdalin metabolisation on host health remain uncertain from the experiments conducted, the manuscript could be improved through a clearer discussion of future work needed and in parts more careful wording to not prematurely suggest benefits to the host.

   Reviewed by eLife

7. Cortex-wide response mode of VIP-expressing inhibitory neurons by reward and punishment

   This article has 10 authors:

   1. Zoltán Szadai
   2. Hyun-Jae Pi
   3. Quentin Chevy
   4. Katalin Ócsai
   5. Dinu F Albeanu
   6. Balázs Chiovini
   7. Gergely Szalay
   8. Gergely Katona
   9. Adam Kepecs
   10. Balázs Rózsa

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is of potential interest to neuroscientists expert in cortical circuitry and behavioral role of neuron types. The imaging technique used permitted to detect a specific group of cortical neurons known as vasoactive intestinal peptide (VIP)-expressing interneurons from several cortical regions with high temporal resolution. The main message conveyed by this manuscript is that many VIP-expressing interneurons respond to reward and punishment but also show regional differences. The conclusions drawn are generally supported by the data, but some claims and interpretations require further attention and clarification.

   Reviewed by eLife

8. Methylglyoxal-derived hydroimidazolone, MG-H1, increases food intake by altering tyramine signaling via the GATA transcription factor ELT-3 in Caenorhabditis elegans

   This article has 14 authors:

   1. Muniesh Muthaiyan Shanmugam
   2. Jyotiska Chaudhuri
   3. Durai Sellegounder
   4. Amit Kumar Sahu
   5. Sanjib Guha
   6. Manish Chamoli
   7. Brian Hodge
   8. Neelanjan Bose
   9. Charis Amber
   10. Dominique O Farrera
   11. Gordon Lithgow
   12. Richmond Sarpong
   13. James J Galligan
   14. Pankaj Kapahi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The work, which examines how Advanced Glycation End-products (AGEs), commonly found in processed and other cooked foods, affect eating behavior and signaling in the nematode C. elegans, is in a fundamentally important area of research with clear translational potential for humans. Some aspects of the manuscript are compelling, including the well-characterized assays on food intake, while other aspects are still incomplete, such as the mechanistic work on the neural network responsible for the response to AGEs.

   Reviewed by eLife

9. A fear conditioned cue orchestrates a suite of behaviors in rats

   This article has 8 authors:

   1. Amanda Chu
   2. Nicholas T Gordon
   3. Aleah M DuBois
   4. Christa B Michel
   5. Katherine E Hanrahan
   6. David C Williams
   7. Stefano Anzellotti
   8. Michael A McDannald

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important and timely characterization of a diversity of behaviors male and female rats exhibit during the acquisition of Pavlovian fear conditioning in a conditioned suppression procedure. The data are compelling and provide an exhaustive analysis of behavior in a complex associative learning paradigm that blends aversive Pavlovian and appetitive instrumental elements. The generalizability of these findings to other paradigms could be enhanced, however, with the inclusion of tests of cue responses in a neutral environment. These findings are likely to be of interest to those who study fear conditioning and associative learning more broadly in rodents.

   Reviewed by eLife

10. Predictive performance of multi-model ensemble forecasts of COVID-19 across European nations

    This article has 129 authors:

    1. Katharine Sherratt
    2. Hugo Gruson
    3. Rok Grah
    4. Helen Johnson
    5. Rene Niehus
    6. Bastian Prasse
    7. Frank Sandmann
    8. Jannik Deuschel
    9. Daniel Wolffram
    10. Sam Abbott
    11. Alexander Ullrich
    12. Graham Gibson
    13. Evan L Ray
    14. Nicholas G Reich
    15. Daniel Sheldon
    16. Yijin Wang
    17. Nutcha Wattanachit
    18. Lijing Wang
    19. Jan Trnka
    20. Guillaume Obozinski
    21. Tao Sun
    22. Dorina Thanou
    23. Loic Pottier
    24. Ekaterina Krymova
    25. Jan H Meinke
    26. Maria Vittoria Barbarossa
    27. Neele Leithauser
    28. Jan Mohring
    29. Johanna Schneider
    30. Jaroslaw Wlazlo
    31. Jan Fuhrmann
    32. Berit Lange
    33. Isti Rodiah
    34. Prasith Baccam
    35. Heidi Gurung
    36. Steven Stage
    37. Bradley Suchoski
    38. Jozef Budzinski
    39. Robert Walraven
    40. Inmaculada Villanueva
    41. Vit Tucek
    42. Martin Smid
    43. Milan Zajicek
    44. Cesar Perez Alvarez
    45. Borja Reina
    46. Nikos I Bosse
    47. Sophie R Meakin
    48. Lauren Castro
    49. Geoffrey Fairchild
    50. Isaac Michaud
    51. Dave Osthus
    52. Pierfrancesco Alaimo Di Loro
    53. Antonello Maruotti
    54. Veronika Eclerova
    55. Andrea Kraus
    56. David Kraus
    57. Lenka Pribylova
    58. Bertsimas Dimitris
    59. Michael Lingzhi Li
    60. Soni Saksham
    61. Jonas Dehning
    62. Sebastian Mohr
    63. Viola Priesemann
    64. Grzegorz Redlarski
    65. Benjamin Bejar
    66. Giovanni Ardenghi
    67. Nicola Parolini
    68. Giovanni Ziarelli
    69. Wolfgang Bock
    70. Stefan Heyder
    71. Thomas Hotz
    72. David E Singh
    73. Miguel Guzman-Merino
    74. Jose L Aznarte
    75. David Morina
    76. Sergio Alonso
    77. Enric Alvarez
    78. Daniel Lopez
    79. Clara Prats
    80. Jan Pablo Burgard
    81. Arne Rodloff
    82. Tom Zimmermann
    83. Alexander Kuhlmann
    84. Janez Zibert
    85. Fulvia Pennoni
    86. Fabio Divino
    87. Marti Catala
    88. Gianfranco Lovison
    89. Paolo Giudici
    90. Barbara Tarantino
    91. Francesco Bartolucci
    92. Giovanna Jona Lasinio
    93. Marco Mingione
    94. Alessio Farcomeni
    95. Ajitesh Srivastava
    96. Pablo Montero-Manso
    97. Aniruddha Adiga
    98. Benjamin Hurt
    99. Bryan Lewis
    100. Madhav Marathe
    101. Przemyslaw Porebski
    102. Srinivasan Venkatramanan
    103. Rafal P Bartczuk
    104. Filip Dreger
    105. Anna Gambin
    106. Krzysztof Gogolewski
    107. Magdalena Gruziel-Slomka
    108. Bartosz Krupa
    109. Antoni Moszyński
    110. Karol Niedzielewski
    111. Jedrzej Nowosielski
    112. Maciej Radwan
    113. Franciszek Rakowski
    114. Marcin Semeniuk
    115. Ewa Szczurek
    116. Jakub Zielinski
    117. Jan Kisielewski
    118. Barbara Pabjan
    119. Kirsten Holger
    120. Yuri Kheifetz
    121. Markus Scholz
    122. Biecek Przemyslaw
    123. Marcin Bodych
    124. Maciej Filinski
    125. Radoslaw Idzikowski
    126. Tyll Krueger
    127. Tomasz Ozanski
    128. Johannes Bracher
    129. Sebastian Funk

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This large-scale collaborative study is a timely contribution that will be of interest to researchers working in the fields of infectious disease forecasting and epidemic control. This paper provides a comprehensive evaluation of the predictive skills of real-time COVID-19 forecasting models in Europe. The conclusions of the paper are well supported by the data and are consistent with findings from studies in other countries.

    Reviewed by eLife