eLife

Latest preprint reviews

1. Quantitative trait and transcriptome analysis of genetic complexity underpinning cardiac interatrial septation in mice using an advanced intercross line

   This article has 15 authors:

   1. Mahdi Moradi Marjaneh
   2. Edwin P Kirk
   3. Ralph Patrick
   4. Dimuthu Alankarage
   5. David T Humphreys
   6. Gonzalo Del Monte-Nieto
   7. Paola Cornejo-Paramo
   8. Vaibhao Janbandhu
   9. Tram B Doan
   10. Sally L Dunwoodie
   11. Emily S Wong
   12. Chris Moran
   13. Ian CA Martin
   14. Peter C Thomson
   15. Richard P Harvey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study of mouse genetic variation in atrial septum formation, a trait correlated with the patent foramen ovale (PFO) cardiac defect, provides convincing evidence for 37 quantitative trait loci (QTL) affecting this trait, combining genetic mapping with transcriptome analysis to zero in on relevant pathways and candidate genes within the QTL, and validating the role of one gene in tissue culture. The paper provides an important resource for hypothesis generation and future studies, which could lead to novel diagnostic or therapeutic approaches that target atrial septal defects in common congenital heart disease.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2022.12.15.520660

3. Lipid hydroperoxides promote sarcopenia through carbonyl stress

   This article has 20 authors:

   1. Hiroaki Eshima
   2. Justin L Shahtout
   3. Piyarat Siripoksup
   4. MacKenzie J Pearson
   5. Ziad S Mahmassani
   6. Patrick J Ferrara
   7. Alexis W Lyons
   8. John Alan Maschek
   9. Alek D Peterlin
   10. Anthony RP Verkerke
   11. Jordan M Johnson
   12. Anahy Salcedo
   13. Jonathan J Petrocelli
   14. Edwin R Miranda
   15. Ethan J Anderson
   16. Sihem Boudina
   17. Qitao Ran
   18. James E Cox
   19. Micah J Drummond
   20. Katsuhiko Funai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important paper advances our understanding of the role of lipid peroxidation in loss of muscle mass and force-generating capacity during aging and hind-limb suspension. The evidence is in general solid, drawing from experiments in vivo and cell culture using multiple types of manipulations of the formation of lipid peroxides although some weaknesses were identified. The results should be of interest to those who study the molecular basis for sarcopenia and disuse atrophy of skeletal muscle.

   Reviewed by eLife

4. Histone deacetylase 1 maintains lineage integrity through histone acetylome refinement during early embryogenesis

   This article has 6 authors:

   1. Jeff Jiajing Zhou
   2. Jin Sun Cho
   3. Han Han
   4. Ira L Blitz
   5. Wenqi Wang
   6. Ken WY Cho

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this manuscript, the authors investigate the role of histone deacetylases in the spatial epigenetic control of zygotic gene expression in early gastrulation. They discover HDAC1 binding is maternally-controlled and that inhibition of histone acetylation blocks gastrulation and disrupts cell lineage integrity, tied to both positive and negative regulatory effects on gene transcription in space and time. The study contributes to a growing body of evidence that highlights a central role of histone acetylation-deacetylation dynamics in epigenetic regulation of gene expression and cell fating in early tissue patterning of the embryo.

   Reviewed by eLife

5. Ion permeation pathway within the internal pore of P2X receptor channels

   This article has 4 authors:

   1. Stephanie W Tam
   2. Kate Huffer
   3. Mufeng Li
   4. Kenton J Swartz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     This study provides valuable insight into the molecular mechanism of ion selectivity in the broader family of ATP-gated P2X receptors. The experimental data are of high quality, the evidence supporting the conclusions is convincing, and the work will be of broad interest to biophysicists working on ion channel selectivity.

   Reviewed by eLife

6. Concurrent decoding of distinct neurophysiological fingerprints of tremor and bradykinesia in Parkinson’s disease

   This article has 6 authors:

   1. Peter M Lauro
   2. Shane Lee
   3. Daniel E Amaya
   4. David D Liu
   5. Umer Akbar
   6. Wael F Asaad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study aimed to identify rhythms linked to primary symptoms of Parkinson's disease such as involuntary shaking of the limbs and slowness. The evidence supporting the conclusions is solid, although validating their behavioural measures and considering the relationship between signatures from different brain regions would have strengthened the study. The work will be of broad interest to movement control, movement disorders, and brain stimulation fields.

   Reviewed by eLife

7. Origin of wiring specificity in an olfactory map revealed by neuron type–specific, time-lapse imaging of dendrite targeting

   This article has 11 authors:

   1. Kenneth Kin Lam Wong
   2. Tongchao Li
   3. Tian-Ming Fu
   4. Gaoxiang Liu
   5. Cheng Lyu
   6. Sayeh Kohani
   7. Qijing Xie
   8. David J Luginbuhl
   9. Srigokul Upadhyayula
   10. Eric Betzig
   11. Liqun Luo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     When a neuron is born it correlates with where it targets in the neuropil and this has been best demonstrated in the olfactory lobe of Drosophila. This important study uses sophisticated genetics and advanced live imaging to provide a compelling description of how neuronal dendrites explore the targeting field, eliminate excessive branches, and assort into the correct region during development. In the process, it develops valuable tools. It brings us closer to a comprehensive understanding of how the birth order of a neuron translates to dendrite patterning within the Drosophila antennal lobe circuit

   Reviewed by eLife

8. UBQLN2 restrains the domesticated retrotransposon PEG10 to maintain neuronal health in ALS

   This article has 12 authors:

   1. Holly H Black
   2. Jessica L Hanson
   3. Julia E Roberts
   4. Shannon N Leslie
   5. Will Campodonico
   6. Christopher C Ebmeier
   7. G Aaron Holling
   8. Jian Wei Tay
   9. Autumn M Matthews
   10. Elizabeth Ung
   11. Cristina I Lau
   12. Alexandra M Whiteley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Black et al., provide evidence that levels of Paternally Expressed Gene 10 (PEG10) protein are regulated by Ubqln2 and that proteolytic fragments from PEG10 cleavage induce changes in gene expression, in particular genes that encode proteins involved in axon biology. Based on these data and the finding of an increase in PEG10 levels and alterations of proteins regulated by PEG10 in the spinal cord of ALS patients, they propose that abnormal induction of PEG10-regulated genes is involved in ALS. However, the evidence for these claims and PEG10 involvement could be strengthened, and the rigor of the work could be enhanced in places.

   Reviewed by eLife

9. Cortical magnification eliminates differences in contrast sensitivity across but not around the visual field

   This article has 4 authors:

   1. Michael Jigo
   2. Daniel Tavdy
   3. Marc M Himmelberg
   4. Marisa Carrasco

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides a provocative potential challenge to explain sensitivity across the visual field by using cortical magnification factors. The evidence supporting this theoretical challenge is solid in general, although the inclusion of subject-specific measurements of cortical magnification factors would have strengthened the study. The work will be of interest to vision researchers of both basic and medical science.

   Reviewed by eLife

10. Neural dynamics underlying self-control in the primate subthalamic nucleus

    This article has 2 authors:

    1. Benjamin Pasquereau
    2. Robert S Turner

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This valuable study by Pasquereau and Turner examined the activity neurons in the subthalamic nucleus (STN) while monkeys performed a task in which they had to withhold their response during a delay period whose length was defined by a specific cue. The results indicate that the activity of STN neurons was modulated by reward size and delay. The results are potentially important for understanding how STN regulates behavior such as self-control, but the reviewers thought that the study is incomplete as the analyses, at least in the presented forms, have some potential problems and some analyses require clarification.

    Reviewed by eLife