eLife

Latest preprint reviews

1. Coordinated cadherin functions sculpt respiratory motor circuit connectivity

   This article has 11 authors:

   1. Alicia N Vagnozzi
   2. Matthew T Moore
   3. Minshan Lin
   4. Elyse M Brozost
   5. Ritesh KC
   6. Aambar Agarwal
   7. Lindsay A Schwarz
   8. Xin Duan
   9. Niccolò Zampieri
   10. Lynn T Landmesser
   11. Polyxeni Philippidou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an extremely thorough investigation of the role of cadherins in generating a functional motor circuit. The presented data support a model whereby combinations of redundant adhesion molecules create a code to wire the breathing circuit. This study advances understanding of the molecular basis of circuit wiring in the brain.

   Reviewed by eLife

2. Cortical activity during naturalistic music listening reflects short-range predictions based on long-term experience

   This article has 4 authors:

   1. Pius Kern
   2. Micha Heilbron
   3. Floris P de Lange
   4. Eelke Spaak

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study models the predictions a listener makes in music in two ways: how different model algorithms compare in their performance at predicting the upcoming notes in a melody, and how well they predict listeners' brain responses to these notes. The study will be valuable to the field as it implements three contemporary models of music prediction. In a set of solid analyses, the authors find that musical melodies are best predicted by models taking into account long-term experience of musical melodies, whereas brain responses are best predicted by applying these models to only a few most recent notes.

   Reviewed by eLife

3. Mechanisms and functions of respiration-driven gamma oscillations in the primary olfactory cortex

   This article has 3 authors:

   1. Joaquin Gonzalez
   2. Pablo Torterolo
   3. Adriano BL Tort

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study employs a publicly available dataset to examine the role of gamma oscillations in the coding of olfactory information in the mouse piriform cortex. The authors convincingly show that gamma originates in the piriform cortex, is driven by feedback inhibition, and that the time course of odour decoding is most accurate when gamma oscillations are strongest. This work is relevant to a wide audience interested in the mechanisms and role of oscillations in the brain, and nicely demonstrates the benefits of well-curated, publicly available datasets.

   Reviewed by eLife

4. Derivation and external validation of clinical prediction rules identifying children at risk of linear growth faltering

   This article has 10 authors:

   1. Sharia M Ahmed
   2. Ben J Brintz
   3. Patricia B Pavlinac
   4. Lubaba Shahrin
   5. Sayeeda Huq
   6. Adam C Levine
   7. Eric J Nelson
   8. James A Platts-Mills
   9. Karen L Kotloff
   10. Daniel T Leung

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work would be of interest to global health scientists, particularly in low- and middle-income countries where childhood stunting is an ongoing challenge, and to statisticians interested in building clinical prediction rules. The authors leveraged large, rich datasets from multi-center studies to build and validate predictive models. But by using change in growth, rather than absolute growth, as the only outcome, it may be missing children of concern who are already experiencing growth failure and require intervention but have reached a growth faltering floor.

   Reviewed by eLife

5. NPAS4 in the medial prefrontal cortex mediates chronic social defeat stress-induced anhedonia-like behavior and reductions in excitatory synapses

   This article has 14 authors:

   1. Brandon W Hughes
   2. Benjamin M Siemsen
   3. Evgeny Tsvetkov
   4. Stefano Berto
   5. Jaswinder Kumar
   6. Rebecca G Cornbrooks
   7. Rose Marie Akiki
   8. Jennifer Y Cho
   9. Jordan S Carter
   10. Kirsten K Snyder
   11. Ahlem Assali
   12. Michael D Scofield
   13. Christopher W Cowan
   14. Makoto Taniguchi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a very interesting manuscript that will be of interest to the field of stress neurobiology and neuropsychiatry. Claims about the interactions between stress and medial prefrontal cortex NPAS4 on anhedonia and motivation remain to be firmly established, yet clear evidence is provided for NPAS4 function on medial prefrontal cortex pyramidal neuron dendritic morphology and gene expression.

   Reviewed by eLife

6. Molecular mechanism underlying desensitization of the proton-activated chloride channel PAC

   This article has 7 authors:

   1. James Osei-Owusu
   2. Zheng Ruan
   3. Ljubica Mihaljević
   4. Daniel S Matasic
   5. Kevin Hong Chen
   6. Wei Lü
   7. Zhaozhu Qiu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work, of interest to ion channel physiologists, identifies regions involved in the desensitization of the proton-activated chloride channel (PAC), a widely expressed ion channel involved in organelle pH homeostasis and acid-induced cell death. At the present stage the data only incompletely support the interpretations, and further experiments will be required to consolidate some of the authors' claims.

   Reviewed by eLife

7. Long term intrinsic cycling in human life course antibody responses to influenza A(H3N2): an observational and modeling study

   This article has 13 authors:

   1. Bingyi Yang
   2. Bernardo García-Carreras
   3. Justin Lessler
   4. Jonathan M Read
   5. Huachen Zhu
   6. C Jessica E Metcalf
   7. James A Hay
   8. Kin O Kwok
   9. Ruiyun Shen
   10. Chao Q Jiang
   11. Yi Guan
   12. Steven Riley
   13. Derek A Cummings

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript follows the still unanswered concept of 'original antigenic sin' and shows the existence of a 24-year periodicity of the immune response against influenza H3N2. The valuable work suggests a long-term periodicity of individual antibody response to influenza A (H3N2) within a city. But, to substantiate their argument, the authors would need to to provide additional supporting data.

   Reviewed by eLife

8. Columnar neurons support saccadic bar tracking in Drosophila

   This article has 2 authors:

   1. Giovanni Frighetto
   2. Mark A Frye

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides valuable new insight into the neural encoding and behavioral tracking of visual objects in the Drosophila. It provides solid evidence that a specific type of neuron in the fly visual system (T3 neuron) is involved in the tracking of moving objects during flight. With additional experimental evidence to resolve whether T3 neurons function as local object detectors, this paper would be of broad interest to visual neuroscientists.

   Reviewed by eLife

9. Approximating missing epidemiological data for cervical cancer through Footprinting: A case study in India

   This article has 4 authors:

   1. Irene Man
   2. Damien Georges
   3. Maxime Bonjour
   4. Iacopo Baussano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work presents a framework for estimating missing data on cervical cancer epidemiology. If properly validated, it could help determine missing data in regions where data are scarce. The work will be of broad interest to researchers and policymakers evaluating cervical cancer prevention measures.

   Reviewed by eLife

10. Vitamin B2 enables regulation of fasting glucose availability

    This article has 21 authors:

    1. Peter M Masschelin
    2. Pradip Saha
    3. Scott A Ochsner
    4. Aaron R Cox
    5. Kang Ho Kim
    6. Jessica B Felix
    7. Robert Sharp
    8. Xin Li
    9. Lin Tan
    10. Jun Hyoung Park
    11. Liping Wang
    12. Vasanta Putluri
    13. Philip L Lorenzi
    14. Alli M Nuotio-Antar
    15. Zheng Sun
    16. Benny Abraham Kaipparettu
    17. Nagireddy Putluri
    18. David D Moore
    19. Scott A Summers
    20. Neil J McKenna
    21. Sean M Hartig

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Masschelin et al. investigate the role of Vitamin B2 (riboflavin), an essential cofactor for FAD and FMN coenzymes involved in the electron transport chain and TCA cycle, in fasting glucose metabolism. This study phenotypes B2-deficient mice liver and provides valuable data on genes and metabolites that are changed with B2 depletion +/- Fenofibrate administration. The work employs solid methodology and will be of interest to liver physiologists interested in fasting in the context of PPAR.

    Reviewed by eLife