eLife

Latest preprint reviews

1. Lipid homeostasis is essential for a maximal ER stress response

   This article has 7 authors:

   1. Gilberto Garcia
   2. Hanlin Zhang
   3. Sophia Moreno
   4. C Kimberly Tsui
   5. Brant Michael Webster
   6. Ryo Higuchi-Sanabria
   7. Andrew Dillin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study addresses the anticipated but poorly understood interconnections between ER proteostasis and lipid metabolism. The authors discovered key metabolic enzymes required for integration of ER stress and lipid synthesis and followed up with several direct experiments that provide solid evidence for a broad conservation of the described interactions.

   Reviewed by eLife

2. Conscious processing of global and local auditory irregularities causes differentiated heartbeat-evoked responses

   This article has 6 authors:

   1. Diego Candia-Rivera
   2. Federico Raimondo
   3. Pauline Pérez
   4. Lionel Naccache
   5. Catherine Tallon-Baudry
   6. Jacobo D Sitt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Motivated by previous demonstrations that cognitive modulation of heart beat evoked responses (HER) might distinguish minimally consciousness state and unresponsive wakefulness syndrome patients, the present work sought to determine whether contextual processing of auditory regularities (local-global paradigm) differentially affects HER in these patient groups. The results provide preliminary evidence for the usefulness of EEG and oddball paradigms in informing diagnosis of the state of consciousness. This paper will be of interest to those researchers studying signs of consciousness in post-comatose patients and more broadly to those studying brain-body interactions. However, some aspects of the study design and data analysis need to be clarified, particularly as these affect the conclusions that can be drawn.

   Reviewed by eLife

3. Kazrin promotes dynein/dynactin-dependent traffic from early to recycling endosomes

   This article has 8 authors:

   1. Ines Hernandez-Perez
   2. Javier Rubio
   3. Adrian Baumann
   4. Henrique Girao
   5. Miriam Ferrando
   6. Elena Rebollo
   7. Anna M Aragay
   8. María Isabel Geli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Hernandez-Perez et al. perform a detailed analysis of Kazrin, a widely expressed protein that appears to be involved in many diverse cellular processes, but whose exact function is unknown. The authors employ mouse embryonic fibroblasts and biochemistry to investigate the function of Kazrin and determine that Kazrin promotes the dynein/dynactin-dependent transport of early endosomes. These findings are valuable to those in the field of intracellular transport, but the story will benefit from additional experiments to prove the main claims, or from textual modifications.

   Reviewed by eLife

4. Prolonged nicotine exposure reduces aversion to the drug in mice by altering nicotinic transmission in the interpeduncular nucleus

   This article has 13 authors:

   1. Sarah Mondoloni
   2. Claire Nguyen
   3. Eléonore Vicq
   4. Maria Ciscato
   5. Joachim Jehl
   6. Romain Durand-de Cuttoli
   7. Nicolas Torquet
   8. Stefania Tolu
   9. Stéphanie Pons
   10. Uwe Maskos
   11. Fabio Marti
   12. Philippe Faure
   13. Alexandre Mourot

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In the current study, Mondoloni and colleagues reveal how a selective nicotine receptor in the interpeduncular nucleus is involved in nicotine consumption, which is an important contribution to the understanding of individual differences in drug addiction. However, the preferred hypothesis would benefit from testing in additional experimental models, metabolic assessment, and cell-type specificity.

   Reviewed by eLife

5. cAMP−EPAC−PKCε−RIM1α signaling regulates presynaptic long-term potentiation and motor learning

   This article has 15 authors:

   1. Xin-Tai Wang
   2. Lin Zhou
   3. Bin-Bin Dong
   4. Fang-Xiao Xu
   5. De-Juan Wang
   6. En-Wei Shen
   7. Xin-Yu Cai
   8. Yin Wang
   9. Na Wang
   10. Sheng-Jian Ji
   11. Wei Chen
   12. Martijn Schonewille
   13. J Julius Zhu
   14. Chris I De Zeeuw
   15. Ying Shen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The cerebellum plays a critical role in motor learning, but exactly which forms of synaptic plasticity contribute to learning, as well as the underlying molecular mechanisms, remain poorly understood. In this study, Wang and colleagues show that presynaptic long-term potentiation at the parallel fiber to Purkinje cell synapse is required for one form of motor learning, and involves a previously-unknown signaling cascade, where EPAC activation leads to PKCε-dependent threonine phosphorylation of RIM1α. This study provides new insights into the underlying mechanisms and functional consequences of presynaptic LTP.

   Reviewed by eLife

6. Global change in brain state during spontaneous and forced walk in Drosophila is composed of combined activity patterns of different neuron classes

   This article has 4 authors:

   1. Sophie Aimon
   2. Karen Y Cheng
   3. Julijana Gjorgjieva
   4. Ilona C Grunwald Kadow

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper expands on prior work by using whole-brain calcium imaging in Drosophila to examine how spontaneous and forced walking and turning affect neural activity in the brain. The measurements presented will serve as a valuable resource for the fly systems neuroscience community and suggest many testable hypotheses that may serve as the basis for future studies. Analyses of the data are solid, but conclusions drawn should be presented with more caveats. This article will be of interest to neuroscientists engaged with the central problem of how behavior modulates neural activity.

   Reviewed by eLife

7. Optical tools for visualizing and controlling human GLP-1 receptor activation with high spatiotemporal resolution

   This article has 8 authors:

   1. Loïc Duffet
   2. Elyse T Williams
   3. Andrea Gresch
   4. Simin Chen
   5. Musadiq A Bhat
   6. Dietmar Benke
   7. Nina Hartrampf
   8. Tommaso Patriarchi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable Tools and Resources paper presents new tools for investigating GLP-1 signaling: a genetically-encoded sensor constructed from a mutated GLP1R receptor as well as a caged agonist peptide. The evidence for these tools working as advertised is solid and they may be helpful for screening compounds that bind to GLP1R.

   Reviewed by eLife

8. Autoinhibited kinesin-1 adopts a hierarchical folding pattern

   This article has 8 authors:

   1. Zhenyu Tan
   2. Yang Yue
   3. Felipe Leprevost
   4. Sarah Haynes
   5. Venkatesha Basrur
   6. Alexey I Nesvizhskii
   7. Kristen J Verhey
   8. Michael A Cianfrocco

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper will be of significant interest to the research community working on cytoplasmic transport and microtubule motors, offering important insights into the structural arrangement of autoinhibited Kinesin-1. The paper reports a structural model of full-length kinesin-1 describing its autoinhibitory mechanism using cryo-EM, Alphafold structural predictions, cross-linking, and mass spectrometry. The data are of high quality and together offer a compelling model for how Kinesin-1 is autoinhibited, indicating that auto-inhibition does not rely on the IAK motif alone but on a more extensive intramolecular interface.

   Reviewed by eLife

9. A simple mechanism for integration of quorum sensing and cAMP signalling in Vibrio cholerae

   This article has 6 authors:

   1. Lucas M Walker
   2. James RJ Haycocks
   3. Julia C Van Kessel
   4. Triana N Dalia
   5. Ankur B Dalia
   6. David C Grainger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides valuable new information on the mechanisms by which Vibrio cholerae integrates and responds to environmental signals. The strength of the evidence provided in support of the conclusions made and the model proposed is solid. The revision resolved many of the issues raised by the reviewers and improved the manuscript. The work is relevant for a broad audience of microbiologists interested in the mechanisms by which bacteria sense their environment.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2022.09.08.507137