eLife

Latest preprint reviews

1. Contrasting action and posture coding with hierarchical deep neural network models of proprioception

   This article has 6 authors:

   1. Kai J Sandbrink
   2. Pranav Mamidanna
   3. Claudio Michaelis
   4. Matthias Bethge
   5. Mackenzie Weygandt Mathis
   6. Alexander Mathis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript presents a valuable framework and blueprint for the study, in artificial systems, of the principles and mechanisms that underlie proprioception in biological systems. Using artificial neural networks trained on synthetic hand movement data, the authors present solid, albeit incomplete, evidence that action recognition can explain important features of the mechanisms that underlie proprioception in biological systems. Experiments with architectures trained using losses that, in addition to action, take into account velocity and/or other states, could strengthen the authors' findings.

   Reviewed by eLife

2. Transcriptional drifts associated with environmental changes in endothelial cells

   This article has 14 authors:

   1. Yalda Afshar
   2. Feyiang Ma
   3. Austin Quach
   4. Anhyo Jeong
   5. Hannah L Sunshine
   6. Vanessa Freitas
   7. Yasaman Jami-Alahmadi
   8. Raphael Helaers
   9. Xinmin Li
   10. Matteo Pellegrini
   11. James A Wohlschlegel
   12. Casey E Romanoski
   13. Miikka Vikkula
   14. M Luisa Iruela-Arispe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment’

     This paper is of interest to a broad audience of cell biologists, and researchers who work with cultured endothelial cells. The work uncovers the impact of culture conditions on transcriptional changes of endothelial cells and demonstrates that some of these changes can be recovered by sheer forces or coculture. The authors provide valuable datasets which will be a good resource for the community.

   Reviewed by eLife

3. Quantifying the impact of immune history and variant on SARS-CoV-2 viral kinetics and infection rebound: A retrospective cohort study

   This article has 25 authors:

   1. James A Hay
   2. Stephen M Kissler
   3. Joseph R Fauver
   4. Christina Mack
   5. Caroline G Tai
   6. Radhika M Samant
   7. Sarah Connolly
   8. Deverick J Anderson
   9. Gaurav Khullar
   10. Matthew MacKay
   11. Miral Patel
   12. Shannan Kelly
   13. April Manhertz
   14. Isaac Eiter
   15. Daisy Salgado
   16. Tim Baker
   17. Ben Howard
   18. Joel T Dudley
   19. Christopher E Mason
   20. Manoj Nair
   21. Yaoxing Huang
   22. John DiFiori
   23. David D Ho
   24. Nathan D Grubaugh
   25. Yonatan H Grad

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides a valuable and policy-relevant contribution to our understanding of SARS-CoV-2 viral kinetics in the Omicron era. The authors exploit a rich and unique dataset from the National Basketball Association to describe post-infection viral kinetics and explore evidence for differential kinetics by immune history and demographics. The authors show (as others have) that most people remain with high viral loads 5 days post positive test (though less so in groups who are tested in a more realistic manner), and that older individuals and those who were boosted (but had a poor initial response to the primary vaccine series) were more likely to remain with high viral loads longer after an Omicron infection, while also describing rebound frequencies after Omicron infections.

   Reviewed by eLife, ScreenIT

4. The injured sciatic nerve atlas (iSNAT), insights into the cellular and molecular basis of neural tissue degeneration and regeneration

   This article has 17 authors:

   1. Xiao-Feng Zhao
   2. Lucas D Huffman
   3. Hannah Hafner
   4. Mitre Athaiya
   5. Matthew C Finneran
   6. Ashley L Kalinski
   7. Rafi Kohen
   8. Corey Flynn
   9. Ryan Passino
   10. Craig N Johnson
   11. David Kohrman
   12. Riki Kawaguchi
   13. Lynda JS Yang
   14. Jeffery L Twiss
   15. Daniel H Geschwind
   16. Gabriel Corfas
   17. Roman J Giger

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In peripheral nerve injury, an immune response occurs to ensure debris clean-up and potential repair, however, there has not yet been a census of cell types and gene expression as these lesions undergo clearance and eventual repair. Zhao et al generate a transcriptional resource by performing scRNAseq on both the naive, injured, and repairing sciatic nerve. They identify the composition of different cell types, gene signatures, and cell-cell communication and contrast these with signatures from the blood, and compare the injured site with distal nerve segments after injury. To dissociate the immune response from injury versus Wallerian degeneration, they use SARM1 KO mice (which exhibits delayed neurodegeneration) and observe that there is still injury-induced immune influx. Overall, this is a convincing study and useful resource for the field of neuronal repair and neural-immune interactions with a clear presentation of the animals and time points, with some follow-up experiments and validation.

   Reviewed by eLife

5. Recurrent network interactions explain tectal response variability and experience-dependent behavior

   This article has 2 authors:

   1. Asaph Zylbertal
   2. Isaac H Bianco

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript uses large-scale neural imaging and network models to show how spontaneous dynamics emerge in such ensembles and how such activity influences behavior. It is a strong addition to the field for explaining many of the observed neural activity patterns and their heterogeneities.

   Reviewed by eLife

6. Integrative modeling reveals the molecular architecture of the intraflagellar transport A (IFT-A) complex

   This article has 9 authors:

   1. Caitlyn L McCafferty
   2. Ophelia Papoulas
   3. Mareike A Jordan
   4. Gabriel Hoogerbrugge
   5. Candice Nichols
   6. Gaia Pigino
   7. David W Taylor
   8. John B Wallingford
   9. Edward M Marcotte

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper will be of interest to scientists working on cilia, intraflagellar transport, and structural modeling. Using an integrative modeling approach, the paper provides a fundamental structural model for a part of the molecular machinery that is responsible for cilium assembly. However, additional approaches would improve confidence in the as yet incomplete structure model.

   Reviewed by eLife

7. High-resolution imaging of the osteogenic and angiogenic interface at the site of murine cranial bone defect repair via multiphoton microscopy

   This article has 6 authors:

   1. Kevin Schilling
   2. Yuankun Zhai
   3. Zhuang Zhou
   4. Bin Zhou
   5. Edward Brown
   6. Xinping Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors present very exciting findings on the cranial bone defect repair using cutting-edge multiphoton imaging to study the role of different vessel subtypes and related oxygen and metabolic microenvironments. The study used microscopy to visualize the oxygen distribution and energy metabolism within the defects at different time points during the process of bone healing. This allows one to understand the pathophysiological progressions of bone diseases and regeneration. It will also provide critical information to optimize the therapeutic bone healing and regeneration approach for different clinical situations.

   Reviewed by eLife

8. A role for the centrosome in regulating the rate of neuronal efferocytosis by microglia in vivo

   This article has 6 authors:

   1. Katrin Möller
   2. Max Brambach
   3. Ambra Villani
   4. Elisa Gallo
   5. Darren Gilmour
   6. Francesca Peri

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is an important contribution to the microglia field and will be of interest to a broad readership in the fields of neurobiology, cell biology and immunology. This work describes fundamental mechanisms of efferocytosis by microglia and uses impressive imaging in zebrafish, in combination with molecular manipulations, to provide compelling data of how centrosome movements synchronize with phagocytic cup formation during microglial efferocytosis of neuronal corpses in vivo.

   Reviewed by eLife

9. Chloride-dependent mechanisms of multimodal sensory discrimination and nociceptive sensitization in Drosophila

   This article has 9 authors:

   1. Nathaniel J Himmel
   2. Akira Sakurai
   3. Atit A Patel
   4. Shatabdi Bhattacharjee
   5. Jamin M Letcher
   6. Maggie N Benson
   7. Thomas R Gray
   8. Gennady S Cymbalyuk
   9. Daniel N Cox

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is of interest for somatosensory neurobiologists studying how polymodality is achieved in peripheral sensory neurons. The work identifies roles in cold nociception and not mechanosensation in chloride transport for a number of ion channels.

   Reviewed by eLife

10. Sugar sensation and mechanosensation in the egg-laying preference shift of Drosophila suzukii

    This article has 6 authors:

    1. Wanyue Wang
    2. Hany KM Dweck
    3. Gaëlle JS Talross
    4. Ali Zaidi
    5. Joshua M Gendron
    6. John R Carlson

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      Wang, Carlson, and colleagues investigate sensory adaptations in the fruit pest Drosophila suzukii, which prefers ripe over overripe fruit. This study focuses on changes in sensory pathways for sugars and food texture, which may contribute to ecological shifts. Several interesting physiological and molecular adaptations are observed in D. suzukii, but it remains unclear whether these observed changes account for behavioral changes.

    Reviewed by eLife