eLife

Latest preprint reviews

1. We couldn't get details of this article at this time:
   10.1101/2022.06.13.495984

2. We couldn't get details of this article at this time:
   10.1101/2022.01.26.477791

3. We couldn't get details of this article at this time:
   10.1101/2022.11.14.516400

4. Cerebellar Activation Bidirectionally Regulates Nucleus Accumbens Core and Medial Shell

   This article has 6 authors:

   1. Alexa F. D’Ambra
   2. Ksenia Vlasov
   3. Se Jung Jung
   4. Swetha Ganesan
   5. Evan G. Antzoulatos
   6. Diasynou Fioravante

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study expands our understanding of the neural circuitry downstream of the cerebellum by describing pathways between the deep cerebellar nuclei and the nucleus accumbens. The authors use a combination of in vivo electrophysiology, electrical and optogenetic stimulation, and both anterograde and retrograde tracing to demonstrate two functional neural pathways. The experiments convincingly support the claims. The finding extends previous investigations about the connections between these two brain areas, and are important for elucidating the role of the cerebellum in influencing functions supported by the nucleus accumbens, such as motivation and reward.

   Reviewed by eLife

5. A theory of hippocampal theta correlations accounting for extrinsic and intrinsic sequences

   This article has 2 authors:

   1. Yuk-Hoi Yiu
   2. Christian Leibold

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important work presents an interesting perspective for the generation and interpretation of phase precession in the hippocampal formation. Through numerical simulations and comparison to experiments, the study provides a convincing theoretical framework explaining the segregation of sequences reflecting navigation and sequences reflecting internal dynamics in the DG-CA3 loop. This study will be of interest for researchers in the spatial navigation and computational neuroscience fields.

   Reviewed by eLife

6. Parallel reconstruction of the excitatory and inhibitory inputs received by single neurons reveals the synaptic basis of recurrent spiking

   This article has 10 authors:

   1. Julian Bartram
   2. Felix Franke
   3. Sreedhar Saseendran Kumar
   4. Alessio Paolo Buccino
   5. Xiaohan Xue
   6. Tobias Gänswein
   7. Manuel Schröter
   8. Taehoon Kim
   9. Krishna Chaitanya Kasuba
   10. Andreas Hierlemann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study makes an important effort to observe and quantify synaptic integration in a large and active network of cultured neurons, using simultaneous patch-clamp and large-scale extracellular recordings. They developed a method to distinguish excitatory and inhibitory contributions, show compelling evidence that the subthreshold activity of these neurons is dominated by few presynaptic neurons. They provide convincing statistics about connectivity and network dynamics.

   Reviewed by eLife

7. Genetic and dietary modulators of the inflammatory response in the gastrointestinal tract of the BXD mouse genetic reference population

   This article has 12 authors:

   1. Xiaoxu Li
   2. Jean-David Morel
   3. Giorgia Benegiamo
   4. Johanne Poisson
   5. Alexis Bachmann
   6. Alexis Rapin
   7. Jonathan Sulc
   8. Evan Williams
   9. Alessia Perino
   10. Kristina Schoonjans
   11. Maroun Bou Sleiman
   12. Johan Auwerx

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study provides a framework for leveraging systems genetics data to dissect mechanisms of gut physiology. The authors provide compelling analyses to highlight diverse modes of interrogating intestinal inflammation, dietary response, and consequent impacts on inflammatory bowel disease. As a resource, it will have great utility for linking genetic variation and diet to gut-related pathophysiologies.

   Reviewed by eLife

8. We couldn't get details of this article at this time:
   10.1101/2022.12.16.520841

9. A novel single alpha-helix DNA-binding domain in CAF-1 promotes gene silencing and DNA damage survival through tetrasome-length DNA selectivity and spacer function

   This article has 7 authors:

   1. Ruben Rosas
   2. Rhiannon R Aguilar
   3. Nina Arslanovic
   4. Anna Seck
   5. Duncan J Smith
   6. Jessica K Tyler
   7. Mair EA Churchill

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The important paper describes the structure of a single alpha helix in the large subunit of the Chromatin Assembly Factor 1 (CAF-1) that binds DNA. The single alpha-helix DNA interaction is novel and, combined with the CAF-1 Winged Helix Domain, is required for CAF-1 function in vivo for gene silencing and DNA damage response. The data are convincing, but there are additional analyses that may be considered.

   Reviewed by eLife

10. α1-Adrenergic receptor–PKC–Pyk2–Src signaling boosts L-type Ca2+ channel CaV1.2 activity and long-term potentiation in rodents

    This article has 11 authors:

    1. Kwun Nok Mimi Man
    2. Peter Bartels
    3. Peter B Henderson
    4. Karam Kim
    5. Mei Shi
    6. Mingxu Zhang
    7. Sheng-Yang Ho
    8. Madeline Nieves-Cintron
    9. Manuel F Navedo
    10. Mary C Horne
    11. Johannes W Hell

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study reports of a new signaling pathway in hippocampal neurons by which alpha-1 receptors for norepinephrine regulates Cav1.2 calcium channels; activation of alpha-1 receptors enhances a form of long-lasting synaptic plasticity that is dependent on L-type calcium channels. The experiments are comprehensive and well executed although additional data are warranted to compellingly support the main conclusions. The work has significance for the field of neuroscience in general and for cellular mechanisms of neuroregulation in particular.

    Reviewed by eLife