eLife

Latest preprint reviews

1. Long term intrinsic cycling in human life course antibody responses to influenza A(H3N2): an observational and modeling study

   This article has 13 authors:

   1. Bingyi Yang
   2. Bernardo García-Carreras
   3. Justin Lessler
   4. Jonathan M Read
   5. Huachen Zhu
   6. C Jessica E Metcalf
   7. James A Hay
   8. Kin O Kwok
   9. Ruiyun Shen
   10. Chao Q Jiang
   11. Yi Guan
   12. Steven Riley
   13. Derek A Cummings

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript follows the still unanswered concept of 'original antigenic sin' and shows the existence of a 24-year periodicity of the immune response against influenza H3N2. The valuable work suggests a long-term periodicity of individual antibody response to influenza A (H3N2) within a city. But, to substantiate their argument, the authors would need to to provide additional supporting data.

   Reviewed by eLife

2. Columnar neurons support saccadic bar tracking in Drosophila

   This article has 2 authors:

   1. Giovanni Frighetto
   2. Mark A Frye

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides valuable new insight into the neural encoding and behavioral tracking of visual objects in the Drosophila. It provides solid evidence that a specific type of neuron in the fly visual system (T3 neuron) is involved in the tracking of moving objects during flight. With additional experimental evidence to resolve whether T3 neurons function as local object detectors, this paper would be of broad interest to visual neuroscientists.

   Reviewed by eLife

3. Approximating missing epidemiological data for cervical cancer through Footprinting: A case study in India

   This article has 4 authors:

   1. Irene Man
   2. Damien Georges
   3. Maxime Bonjour
   4. Iacopo Baussano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work presents a framework for estimating missing data on cervical cancer epidemiology. If properly validated, it could help determine missing data in regions where data are scarce. The work will be of broad interest to researchers and policymakers evaluating cervical cancer prevention measures.

   Reviewed by eLife

4. Vitamin B2 enables regulation of fasting glucose availability

   This article has 21 authors:

   1. Peter M Masschelin
   2. Pradip Saha
   3. Scott A Ochsner
   4. Aaron R Cox
   5. Kang Ho Kim
   6. Jessica B Felix
   7. Robert Sharp
   8. Xin Li
   9. Lin Tan
   10. Jun Hyoung Park
   11. Liping Wang
   12. Vasanta Putluri
   13. Philip L Lorenzi
   14. Alli M Nuotio-Antar
   15. Zheng Sun
   16. Benny Abraham Kaipparettu
   17. Nagireddy Putluri
   18. David D Moore
   19. Scott A Summers
   20. Neil J McKenna
   21. Sean M Hartig

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Masschelin et al. investigate the role of Vitamin B2 (riboflavin), an essential cofactor for FAD and FMN coenzymes involved in the electron transport chain and TCA cycle, in fasting glucose metabolism. This study phenotypes B2-deficient mice liver and provides valuable data on genes and metabolites that are changed with B2 depletion +/- Fenofibrate administration. The work employs solid methodology and will be of interest to liver physiologists interested in fasting in the context of PPAR.

   Reviewed by eLife

5. High-resolution quantitative and functional MRI indicate lower myelination of thin and thick stripes in human secondary visual cortex

   This article has 10 authors:

   1. Daniel Haenelt
   2. Robert Trampel
   3. Shahin Nasr
   4. Jonathan R Polimeni
   5. Roger BH Tootell
   6. Martin I Sereno
   7. Kerrin J Pine
   8. Luke J Edwards
   9. Saskia Helbling
   10. Nikolaus Weiskopf

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript will be of interest to a wide range of neuroscientists and clinicians employing imaging methods. Using a combination of cutting edge high resolution magnetic resonance protocols, the authors investigate the structure-function relationship of specialised compartments in the human cortex in vivo. Their results indicate different patterns of myelination across the "stripes" of visual area V2, but will require further independent validation with myelin staining in the human brain.

   Reviewed by eLife

6. Membrane potential dynamics of excitatory and inhibitory neurons in mouse barrel cortex during active whisker sensing

   This article has 5 authors:

   1. Taro Kiritani
   2. Aurélie Pala
   3. Célia Gasselin
   4. Sylvain Crochet
   5. Carl C. H. Petersen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports the response by cortical interneurons from mice expressing genetically defined fluorescent markers to sensory stimulation performed in awake animals without anesthesia. The data show in some cases distinct responses in specific neuron types. This manuscript contains unique information that will be valuable to other researchers in the field and influence future research in the field of cortical GABAergic neurons.

   Reviewed by eLife

7. Inhibition of the proton-activated chloride channel PAC by PIP2

   This article has 5 authors:

   1. Ljubica Mihaljević
   2. Zheng Ruan
   3. James Osei-Owusu
   4. Wei Lü
   5. Zhaozhu Qiu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Combining electrophysiology, site-directed mutagenesis, lipid pharmacology, and single particle cryo-electron microscopy, this study provides solid evidence identifying a site on the extracellular half of the transmembrane domain of Proton-Activated Chloride (PAC) channels that could be occupied by PIP2 and related lipids to promote channel desensitization. These findings are important because pharmacological information for these biologically relevant ion channels is absent.

   Reviewed by eLife

8. Fecal transplant from myostatin deletion pigs positively impacts the gut-muscle axis

   This article has 16 authors:

   1. Zhao-Bo Luo
   2. Shengzhong Han
   3. Xi-Jun Yin
   4. Hongye Liu
   5. Junxia Wang
   6. Meifu Xuan
   7. Chunyun Hao
   8. Danqi Wang
   9. Yize Liu
   10. Shuangyan Chang
   11. Dongxu Li
   12. Kai Gao
   13. Huiling Li
   14. Biaohu Quan
   15. Lin-Hu Quan
   16. Jin-Dan Kang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Myostatin KO is known to increase muscle mass, but can transplanting the gut microbiome from these animals also increase muscle mass and strength? Based on the experiments performed in this paper, the answer is yes, and the positive impact of myostatin deletion on the gut-muscle axis may proceed through alteration of gut bacterial metabolism, including short-chain fatty acids. This is important work and will contribute to the expanding field of the gut-muscle axis.

   Reviewed by eLife

9. Longitudinal fundus imaging and its genome-wide association analysis provide evidence for a human retinal aging clock

   This article has 14 authors:

   1. Sara Ahadi
   2. Kenneth A Wilson
   3. Boris Babenko
   4. Cory Y McLean
   5. Drew Bryant
   6. Orion Pritchard
   7. Ajay Kumar
   8. Enrique M Carrera
   9. Ricardo Lamy
   10. Jay M Stewart
   11. Avinash Varadarajan
   12. Marc Berndl
   13. Pankaj Kapahi
   14. Ali Bashir

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is an important contribution to the biological aging field using eye image data to create an aging clock of the retina in data from eyePACS with validation in the UK Biobank. The authors provide compelling evidence that the clock correlates with chronological and phenotypic age, predicting mortality independently of chronological age. The work identifies novel genetic loci with a top site located in the ALKAL2 region, which is functionally validated in a Drosophila model.

   Reviewed by eLife

10. Single-cell analysis of the aged ovarian immune system reveals a shift towards adaptive immunity and attenuated cell function

    This article has 4 authors:

    1. Tal Ben Yaakov
    2. Tanya Wasserman
    3. Eliel Aknin
    4. Yonatan Savir

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The study by Ben Yaakov et al. describes a single cell analysis of the mammalian ovary in young, adult and old mice. Based on gene expression profiles, the authors identified cell clusters corresponding to immune cell populations in mouse ovaries and compared their abundance in aged compared to adult animals. In comparison with previous studies that used single cell RNAseq to characterize the heterogeneity of cell types in the ovary, this study focuses only on immune cells resulting in much better coverage to characterize the changes that these cells undergo as a function of age. The combination of single-cell RNA sequencing and flow cytometry used by the authors is a robust and unbiased approach to characterize immune cell alterations in aging ovaries. Overall, the data and analyses presented in this study reveal profound modifications of the immune system in the aging reproductive system in mice. However, while both the data and biology presented are quite interesting, this study is perhaps too wide in breadth such that no individual result is extensively and rigorously explored.

    Reviewed by eLife