eLife

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1. Structure of the connexin-43 gap junction channel in a putative closed state

   This article has 12 authors:

   1. Chao Qi
   2. Silvia Acosta Gutierrez
   3. Pia Lavriha
   4. Alaa Othman
   5. Diego Lopez-Pigozzi
   6. Erva Bayraktar
   7. Dina Schuster
   8. Paola Picotti
   9. Nicola Zamboni
   10. Mario Bortolozzi
   11. Francesco Luigi Gervasio
   12. Volodymyr M Korkhov

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Gap junctions, formed from connexins, are important in cell communication, allowing ions and small molecules to move directly between cells. By determining the Cryo EM structure of the structure of connexin 43 in a putative closed state involving lipids, the study makes an important contribution to the development of a mechanistic model for connexin activation. The connexin 43 structure is solid and its presentation will appeal to the channel and membrane protein communities.

   Reviewed by eLife

2. Allosteric activation or inhibition of PI3Kγ mediated through conformational changes in the p110γ helical domain

   This article has 12 authors:

   1. Noah J Harris
   2. Meredith L Jenkins
   3. Sung-Eun Nam
   4. Manoj K Rathinaswamy
   5. Matthew AH Parson
   6. Harish Ranga-Prasad
   7. Udit Dalwadi
   8. Brandon E Moeller
   9. Eleanor Sheeky
   10. Scott D Hansen
   11. Calvin K Yip
   12. John E Burke

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents fundamental new insight into the regulatory apparatus of PI3Kγ, a kinase in signaling pathways that control the immune response and cancer. A suite of biophysical and biochemical approaches provide convincing evidence for new sites of allosteric control over enzyme activity. The rigorous findings provide structure and dynamic information that may be exploited in efforts to control PI3Kγ activity in a therapeutic setting.

   Reviewed by eLife

3. Atlas of Plasmodium falciparum intraerythrocytic development using expansion microscopy

   This article has 9 authors:

   1. Benjamin Liffner
   2. Ana Karla Cepeda Diaz
   3. James Blauwkamp
   4. David Anaguano
   5. Sonja Frolich
   6. Vasant Muralidharan
   7. Danny W Wilson
   8. Jeffrey D Dvorin
   9. Sabrina Absalon

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides an unprecedented overview of the subcellular organization of proliferative blood stage malaria parasites using expansion microscopy. The localization of multiple parasite organelles is comprehensively probed using three-dimensional super-resolution microscopy throughout the entire intraerythrocytic development cycle. This work provides a compelling framework to investigate in future more deeply the unconventional cell biology of malaria-causing parasites.

   Reviewed by eLife, preLights, Life Science Editors

4. We couldn't get details of this article at this time:
   10.1101/2022.04.21.489011

5. We couldn't get details of this article at this time:
   10.1101/2022.06.08.495407

6. We couldn't get details of this article at this time:
   10.1101/2023.03.23.533972

7. A local ATR-dependent checkpoint pathway is activated by a site-specific replication fork block in human cells

   This article has 9 authors:

   1. Sana Ahmed-Seghir
   2. Manisha Jalan
   3. Helen E Grimsley
   4. Aman Sharma
   5. Shyam Twayana
   6. Settapong T Kosiyatrakul
   7. Christopher Thompson
   8. Carl L Schildkraut
   9. Simon N Powell

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports important data on the cellular response to a single site-specific replication fork block in human MCF7 cells. Compelling evidence shows the efficacy of the bacterial Tus-Ter system to stall replication forks in human cells. Fork stalling let to lasting ATR-dependent phosphorylation of histone H2AX but not of ATR itself and its downstream targets RPA and CHK1.

   Reviewed by eLife

8. Rubella virus tropism and single-cell responses in human primary tissue and microglia-containing organoids

   This article has 7 authors:

   1. Galina Popova
   2. Hanna Retallack
   3. Chang N Kim
   4. Albert Wang
   5. David Shin
   6. Joseph L DeRisi
   7. Tomasz Nowakowski

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript represents an important study on the pathogenesis of rubella virus tropism and neuropathology in human microglia-containing human stem cell derived organoids and human fetal brain slices. The strength of evidence is compelling, employing two different human-relevant models. The findings will be of broad interest to virologists and infectious disease experts, as well as neurodevelopmental biologists. The findings could also be of interest to pediatrics and obstetrics clinical colleagues.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2022.12.02.514196

10. We couldn't get details of this article at this time:
    10.21203/rs.3.rs-2407778/v1