eLife

Latest preprint reviews

1. Functional imaging of conduction dynamics in cortical and spinal axons

   This article has 2 authors:

   1. Milos Radivojevic
   2. Anna Rostedt Punga

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work provides fundamental new insight into fine axonal morphologies based solely on extracellular action potential recordings. They provide compelling evidence of fine resolution in mapping functional connections between neurons. The work may have broad use in neurobiology, bioengineering, stem cell biology, as well as tissue engineering in functional characterization.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.05.10.540142

3. Mechanism of substrate binding and transport in BASS transporters

   This article has 6 authors:

   1. Patrick Becker
   2. Fiona Naughton
   3. Deborah Brotherton
   4. Raul Pacheco-Gomez
   5. Oliver Beckstein
   6. Alexander D Cameron

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript represents an important contribution to an ongoing discussion about the substrate binding site and mechanism of the Bile Acid Sodium Symporter (BASS) family of transporters. Structural and biochemical analysis of a bacterial homolog, ASTBnm, in complex with its native substrate (not bile acids, but a vitamin A precursor, pantoate) show a new binding site that is consistent with classical proposals for elevator-type transport mechanisms. Molecular dynamics (MD) simulations highlight the improved stability for the substrate in the active site when ions are present, suggesting a binding order during the transport cycle. The structural studies, binding assays, and MD simulations are convincing.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.1101/2023.04.27.538609

5. We couldn't get details of this article at this time:
   10.1101/2023.06.06.543661

6. We couldn't get details of this article at this time:
   10.1101/2023.04.19.537271

7. Delayed postglacial colonization of Betula in Iceland and the circum North Atlantic

   This article has 10 authors:

   1. David J Harning
   2. Samuel Sacco
   3. Kesara Anamthawat-Jónsson
   4. Nicolò Ardenghi
   5. Thor Thordarson
   6. Jonathan H Raberg
   7. Julio Sepúlveda
   8. Áslaug Geirsdóttir
   9. Beth Shapiro
   10. Gifford H Miller

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work on the paleovegetation history of Iceland has implications for the field of paleoecology, and the deglaciation history of Iceland and additional localities in Northern America and Europe via woody shrub colonization. The study uses a sedimentary ancient DNA metabarcoding approach to study this historic process. The strength of evidence is solid, with the methods (analysis of sedimentary DNA) and data analyses broadly supporting the claims.

   Reviewed by eLife

8. Ryanodine receptor 2 inhibition reduces dispersion of cardiac repolarization, improves contractile function, and prevents sudden arrhythmic death in failing hearts

   This article has 5 authors:

   1. Pooja Joshi
   2. Shanea Estes
   3. Deeptankar DeMazumder
   4. Bjorn C Knollmann
   5. Swati Dey

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study examined the use of dantrolene, a Ryanodine Receptor stabilizer, in slowing pathological progression of pressure-overload heart failure in a guinea pig model and reducing arrhythmias. Convincing data were collected and analyzed using validated methodology and can be used as a starting point for future studies of dantrolene in Ca2+ handling in ROS production and further deterioration of cardiac function in chronic heart failure.

   Reviewed by eLife

9. We couldn't get details of this article at this time:
   10.1101/2023.04.14.536836

10. We couldn't get details of this article at this time:
    10.1101/2023.01.18.524493