Latest preprint reviews

  1. The PMA phorbol ester tumor promoter increases canonical Wnt signaling via macropinocytosis

    This article has 8 authors:
    1. Nydia Tejeda-Munoz
    2. Yagmur Azbazdar
    3. Julia Monka
    4. Grace Binder
    5. Alex Dayrit
    6. Raul Ayala
    7. Neil O'Brien
    8. Edward M De Robertis
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The strength of this important study is that it provides compelling evidence in several biological models, including Xenopus embryos, that Wnt3a increases macropinocytosis and that PMA increases this cellular response. This novel link between Wnt, focal adhesions, lysosomes, and macropinocytosis will be very interesting for cell and tumor biologists. In future work, it will be good to identify the underlying mechanism, i.e., the molecular node whereby this interaction occurs.

    Reviewed by eLife

    This article has 9 evaluationsAppears in 1 listLatest version Latest activity
  2. Persistence of intact HIV-1 proviruses in the brain during antiretroviral therapy

    This article has 9 authors:
    1. Weiwei Sun
    2. Yelizaveta Rassadkina
    3. Ce Gao
    4. Sarah Isabel Collens
    5. Xiaodong Lian
    6. Isaac H Solomon
    7. Shibani S Mukerji
    8. Xu G Yu
    9. Mathias Lichterfeld
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This important study uses near full-length HIV-1 sequencing to examine proviral persistence in various tissues derived from three individuals who received antiretroviral therapy until time of death. Intact as well as defective HIV-1 proviruses are found at various anatomical sites including the central nervous system; the results are convincing and relevant for our understanding of latent viral reservoirs, especially in the brain.

    Reviewed by eLife

    This article has 7 evaluationsAppears in 2 listsLatest version Latest activity
Newer Page 463 of 871 Older