eLife

Latest preprint reviews

1. Coronary artery established through amniote evolution

   This article has 12 authors:

   1. Kaoru Mizukami
   2. Hiroki Higashiyama
   3. Yuichiro Arima
   4. Koji Ando
   5. Norihiro Okada
   6. Katsumi Kose
   7. Shigehito Yamada
   8. Jun K Takeuchi
   9. Kazuko Koshiba-Takeuchi
   10. Shigetomo Fukuhara
   11. Sachiko Miyagawa-Tomita
   12. Hiroki Kurihara

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Mizukami et al. propose a scenario for the evolutionary origin of the coronary artery in amniotes by comparing the morphologies of the vasculatures across several species and developmental timepoints. They show that the coronary arteries of non-amniotes most closely resemble embryonic amniote aortic subepicardial vessels (ASVs), which are replaced by the true coronary arteries during amniote development. While the identification of common vascular structures in diverse taxa is a valuable contribution, additional developmental evidence is needed to confirm that such vessels are truly homologous.

   Reviewed by eLife

2. Spatial structure favors microbial coexistence except when slower mediator diffusion weakens interactions

   This article has 4 authors:

   1. Alexander Lobanov
   2. Samantha Dyckman
   3. Helen Kurkjian
   4. Babak Momeni

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study uses computational simulations to explore how spatial structure can affect the coexistence between different microbial species, ultimately helping to explain diversity in microbial communities. The evidence supporting the conclusions is solid, although the parameter values used in the simulations were deemed to be unrealistic. Further investigation on whether the conclusions would hold under more realistic assumptions would be very interesting to microbial ecologists quite broadly.

   Reviewed by eLife

3. Complex subsets but redundant clonality after B cells egress from spontaneous germinal centers

   This article has 7 authors:

   1. Carlos Castrillon
   2. Lea Simoni
   3. Theo van den Broek
   4. Cees van der Poel
   5. Elliot H Akama-Garren
   6. Minghe Ma
   7. Michael C Carroll

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Understanding the heterogeneity of the B cell response induced in autoimmune individuals is important for the development of therapies designed to target the cells underlying disease progression. Here the authors use a new mouse model of autoimmunity to assess the heterogeneity of the B cell response using single-cell RNA-sequencing and BCR-sequencing and found that these B cell responses are similar to those by exogenous protein immunization.

   Reviewed by eLife

4. Neuronal glutamate transporters control reciprocal inhibition and gain modulation in D1 medium spiny neurons

   This article has 9 authors:

   1. Maurice A Petroccione
   2. Lianna Y D'Brant
   3. Nurat Affinnih
   4. Patrick H Wehrle
   5. Gabrielle C Todd
   6. Shergil Zahid
   7. Haley E Chesbro
   8. Ian L Tschang
   9. Annalisa Scimemi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript reports important findings that help to understand the function of glutamate transporters and their effects on synaptic function at D1- and D2-MSNs within the dorsolateral striatum. These findings were evaluated to be of interest and well-executed. Overall, the majority of claims are supported by high quality data, but the evidence for some underlying mechanisms and region specificity were incomplete in the manuscript's current form.

   Reviewed by eLife

5. Competing neural representations of choice shape evidence accumulation in humans

   This article has 6 authors:

   1. Krista Bond
   2. Javier Rasero
   3. Raghav Madan
   4. Jyotika Bahuguna
   5. Jonathan Rubin
   6. Timothy Verstynen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study assesses how change in reward contingency in the environment affects the dynamics of a realistic large-scale neural circuit model, human choice behavior, and fMRI responses measured in the same individuals. It is not entirely clear which predictions of the neural circuit model go beyond previous work, the current results seem incomplete and could likely be substantially strengthened. This study could be of interest to scientists studying the neural and computational bases of adaptive behaviour.

   Reviewed by eLife

6. State-dependent coupling of hippocampal oscillations

   This article has 6 authors:

   1. Brijesh Modi
   2. Matteo Guardamagna
   3. Federico Stella
   4. Marilena Griguoli
   5. Enrico Cherubini
   6. Francesco P Battaglia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Traditional approaches for the analysis of brain rhythms typically rely on measuring spectro-temporal properties of individual oscillations or the interactions between two different oscillations. This manuscript presents a novel multivariate approach that uses a state space model to simultaneously analyze the dynamics and interactions of multiple hippocampal oscillations. Such an approach represents a step forward in the field that highlights the need of taking into account the complexity of network interactions rather than trying to understand each component of the system in isolation.

   Reviewed by eLife

7. Mechanistic insights into robust cardiac IKs potassium channel activation by aromatic polyunsaturated fatty acid analogues

   This article has 8 authors:

   1. Briana M Bohannon
   2. Jessica J Jowais
   3. Leif Nyberg
   4. Vanessa Olivier-Meo
   5. Valentina Corradi
   6. D Peter Tieleman
   7. Sara I Liin
   8. H Peter Larsson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work reports important findings regarding the regulation of ion channels by polyunsaturated fatty acids (PUFAs) through the identification of novel aromatic PUFA analogs with potent effects on the IKs channels, which allow for mechanistic insights into their mode of action. The experiments are solid, combining site-directed mutagenesis, electrophysiological and pharmacological approaches to dissect the different molecular mechanisms and sites involved in the functional interactions. This work will be of broad interest to ion channel biophysicists, physiologists, and medical chemists interested in drug development for LQT syndrome. The study presents some limitations that may need to be addressed or further discussed, in order to strengthen the conclusions reached in the study.

   Reviewed by eLife

8. Somatic mutation rates scale with time not growth rate in long-lived tropical trees

   This article has 15 authors:

   1. Akiko Satake
   2. Ryosuke Imai
   3. Takeshi Fujino
   4. Sou Tomimoto
   5. Kayoko Ohta
   6. Mohammad Na'iem
   7. Sapto Indrioko
   8. Widiyatno Widiyatno
   9. Susilo Purnomo
   10. Almudena Molla Morales
   11. Viktoria Nizhynska
   12. Naoki Tani
   13. Yoshihisa Suyama
   14. Eriko Sasaki
   15. Masahiro Kasahara

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Satake and colleagues' important study elucidates somatic mutation processes in plants, demonstrating that in two tropical trees, mutation rates correlate with age, not growth rates. Their convincing evidence shows that many mutations do not align with cell divisions, suggesting many somatic mutations are generated in a replication-independent manner. This study represents a significant step towards advancing our understanding of plant development and the patterns and inheritance of mutations. This significant research is poised to engage a diverse array of scholars in plant evolution and development.

   Reviewed by eLife

9. Chromosomal instability induced in cancer can enhance macrophage-initiated immune responses that include anti-tumor IgG

   This article has 11 authors:

   1. Brandon H Hayes
   2. Mai Wang
   3. Hui Zhu
   4. Steven H Phan
   5. Lawrence J Dooling
   6. Jason C Andrechak
   7. Alexander H Chang
   8. Michael P Tobin
   9. Nicholas M Ontko
   10. Tristan Marchena
   11. Dennis E Discher

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors provide compelling evidence that MSP1 inhibition (leading to chromosomal instability or CIN in the cancer cells) increases phagocytosis and that tumors with CIN respond better to macrophage therapeutics. In this important study, they demonstrate particularly impressive survival rates for mouse models of CIN B16 tumors treated with adoptively transferred macrophages, CD47-SIRPα blockade, and anti-Tyrp1 IgG.

   Reviewed by eLife

10. Oral supplementation of gut microbial metabolite indole-3-acetate alleviates diet-induced steatosis and inflammation in mice

    This article has 10 authors:

    1. Yufang Ding
    2. Karin Yanagi
    3. Fang Yang
    4. Evelyn Callaway
    5. Clint Cheng
    6. Martha E Hensel
    7. Rani Menon
    8. Robert C Alaniz
    9. Kyongbum Lee
    10. Arul Jayaraman

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The studies are important to the field of hepatic steatosis and inflammation. The data provided are convincing that treatment with I3A mitigated Western diet (WD)-induced hepatic steatosis, inflammation and reversed WD-induced alterations in liver bile acids and free fatty acids in mice.

    Reviewed by eLife