eLife

Latest preprint reviews

1. Endosomal dysfunction contributes to cerebellar deficits in spinocerebellar ataxia type 6

   This article has 6 authors:

   1. Anna A Cook
   2. Tsz Chui Sophia Leung
   3. Max Rice
   4. Maya Nachman
   5. Élyse Zadigue-Dube
   6. Alanna Jean Watt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides valuable insights to the underlying mechanism for Spinocerebellar ataxia 6 (SCA6) due to defective endolysosomal trafficking of BDNF and its receptor TrkB. The findings are compelling and significant in understanding the underlying pathology of SCA6. The authors have acknowledged the experimental weaknesses and recognize there may be multiple mechanisms to explain the findings.

   Reviewed by eLife

2. We couldn't get details of this article at this time:
   10.1101/2023.07.21.550014

3. We couldn't get details of this article at this time:
   10.1101/2023.05.23.541921

4. We couldn't get details of this article at this time:
   10.1101/2023.05.26.542533

5. We couldn't get details of this article at this time:
   10.1101/2023.03.09.531681

6. Olfactory detection of viruses shapes brain immunity and behavior in zebrafish

   This article has 9 authors:

   1. Aurora Kraus
   2. Benjamin Garcia
   3. Jie Ma
   4. Kristian J. Herrera
   5. Hanna Zwaka
   6. Roy Harpaz
   7. Ryan Y. Wong
   8. Florian Engert
   9. Irene Salinas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful description of transcriptional responses in adult zebrafish olfactory bulb microglia and neurons following exposure to infectious hematopoietic necrosis virus. This solid work advances our understanding of central nervous system responses to viral infection and provides an inventory of gene expression changes in particular cell types that can be used as hypothesis generators for future studies. Experiments to assess behavioral and neural responses to the virus in adults and larvae are inadequate and would benefit from a clearer conceptual framework that connects these avenues of investigation both to published literature and to the authors' single cell RNA sequencing results.

   Reviewed by eLife

7. We couldn't get details of this article at this time:
   10.1101/2023.07.21.550124

8. We couldn't get details of this article at this time:
   10.1101/2023.05.24.542064

9. We couldn't get details of this article at this time:
   10.1101/2023.04.12.536413

10. We couldn't get details of this article at this time:
    10.1101/2023.05.22.541747