eLife

Latest preprint reviews

1. Structural rather than catalytic role for mitochondrial respiratory chain supercomplexes

   This article has 6 authors:

   1. Michele Brischigliaro
   2. Alfredo Cabrera-Orefice
   3. Susanne Arnold
   4. Carlo Viscomi
   5. Massimo Zeviani
   6. Erika Fernández-Vizarra

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable findings on the organization of respiratory chain complexes in mitochondria. It provides solid evidence that respiratory supercomplex formation in the fruit fly does not impact respiratory function, suggesting the role of these complexes is structural, rather than catalytic. However, whether the conclusions extend to other species requires further evidence. This manuscript will be of broad interest to the field of mitochondrial bioenergetics.

   Reviewed by eLife

2. Rice stripe virus utilizes a Laodelphax striatellus salivary carbonic anhydrase to facilitate plant infection by direct molecular interaction

   This article has 6 authors:

   1. Jing Zhao
   2. Xiangyi Meng
   3. Jie Yang
   4. Rongxiang Fang
   5. Yan Huo
   6. Lili Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study presents a well-designed set of experiments demonstrating how a planthopper salivary carbonic anhydrase can promote rice stripe virus infection by modulating callose deposition in the host plant. The authors provide solid data for the proposed protein-protein interactions, including strengthened evidence for the LssaCA-NP-OsTLP complex and clarified dynamics of LssaCA presence in planta. Overall, the work reveals a mechanistic link whereby a vector salivary protein enhances a plant β-1,3-glucanase to suppress callose-based defense, thereby facilitating early viral establishment.

   Reviewed by eLife

3. σ28-dependent small RNA regulation of flagella biosynthesis

   This article has 7 authors:

   1. Sahar Melamed
   2. Aixia Zhang
   3. Michal Jarnik
   4. Joshua Mills
   5. Aviezer Silverman
   6. Hongen Zhang
   7. Gisela Storz

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This article provides important findings on how bacteria use small RNAs to regulate flagellar expression with implications for multiple fields. The data supporting the conclusions are convincing with a large amount of data that include results from phenotypic analyses, genomics approaches as well as in-vitro and in-vivo target identification and validation methods. This study on the varied effects of three sRNAs (UhpU, FliX and MotR) is of broad interest to RNA biochemists and microbiologists.

   Reviewed by eLife

4. Exploratory mass cytometry analysis reveals immunophenotypes of cancer treatment-related pneumonitis

   This article has 10 authors:

   1. Toyoshi Yanagihara
   2. Kentaro Hata
   3. Keisuke Matsubara
   4. Kazufumi Kunimura
   5. Kunihiro Suzuki
   6. Kazuya Tsubouchi
   7. Satoshi Ikegame
   8. Yoshihiro Baba
   9. Yoshinori Fukui
   10. Isamu Okamoto

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable inventory of immune signatures that are correlated with cancer treatment-related pneumonitis. The data were collected and analysed using validated methodology and can be used as a starting point for further prospective studies. The authors have provided a scRNA-Seq analysis with an HD baseline using publicly available dataset and the evidence for their claims is convincing.

   Reviewed by eLife

5. A novel computational pipeline for var gene expression augments the discovery of changes in the Plasmodium falciparum transcriptome during transition from in vivo to short-term in vitro culture

   This article has 14 authors:

   1. Clare Andradi-Brown
   2. Jan Stephan Wichers-Misterek
   3. Heidrun von Thien
   4. Yannick D Höppner
   5. Judith AM Scholz
   6. Helle Hansson
   7. Emma Filtenborg Hocke
   8. Tim Wolf Gilberger
   9. Michael F Duffy
   10. Thomas Lavstsen
   11. Jake Baum
   12. Thomas D Otto
   13. Aubrey J Cunnington
   14. Anna Bachmann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Focusing mainly on var genes, the investigators performed comprehensive computational analyses of gene expression in malaria parasites isolated from patients and assessed changes that occur as these parasites adapt to in vitro culture conditions. The study provides an improved computational pipeline for monitoring var gene expression, and importantly, the study documents changes in expression of the core genome and thus provides insights into metabolic adaptations that parasites undergo while transitioning to culture conditions. The findings are important for their technical advances that are more rigorous than the current state-of-the-art. The solid data analyses, broadly support the claims with only minor weaknesses, tell us to be cautious when interpreting results obtained only from cultured parasites.

   Reviewed by eLife

6. RBP-J regulates homeostasis and function of circulating Ly6Clo monocytes

   This article has 7 authors:

   1. Tiantian Kou
   2. Lan Kang
   3. Bin Zhang
   4. Jiaqi Li
   5. Baohong Zhao
   6. Wenwen Zeng
   7. Xiaoyu Hu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable examination into the role Notch-RBP-J signalling in regulating monocyte subset homeostasis. The data were collected and analysed using solid and validated methodology and can be used as a starting point for exploring the mechanisms involved in RBP-J signalling in non-classical monocytes. The data presented strongly confirm the authors conclusions. However, this paper primarily focuses on providing a description, and additional studies are necessary to fully elucidate the mechanisms through which RBP-J deficiency contributes to the specific increase in Ly6Clo monocyte numbers in both the blood and lungs.

   Reviewed by eLife

7. Loss of Ptpmt1 limits mitochondrial utilization of carbohydrates and leads to muscle atrophy and heart failure in tissue-specific knockout mice

   This article has 14 authors:

   1. Hong Zheng
   2. Qianjin Li
   3. Shanhu Li
   4. Zhiguo Li
   5. Marco Brotto
   6. Daiana Weiss
   7. Domenick Prosdocimo
   8. Chunhui Xu
   9. Ashruth Reddy
   10. Michelle Puchowicz
   11. Xinyang Zhao
   12. M Neale Weitzmann
   13. Mukesh K Jain
   14. Cheng-Kui Qu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper provides a useful set of data examining the role of PTPMT1, a mitochondria-based phosphatase, in mitochondrial fuel selection. The data were collected and analyzed using solid methodology and can be used as a starting point for further studies that build on the findings here.

   Reviewed by eLife

8. A versatile high-throughput assay based on 3D ring-shaped cardiac tissues generated from human induced pluripotent stem cell-derived cardiomyocytes

   This article has 11 authors:

   1. Magali Seguret
   2. Patricia Davidson
   3. Stijn Robben
   4. Charlène Jouve
   5. Celine Pereira
   6. Quitterie Lelong
   7. Lucille Deshayes
   8. Cyril Cerveau
   9. Maël Le Berre
   10. Rita S Rodrigues Ribeiro
   11. Jean-Sébastien Hulot

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper reports a valuable platform for cardiac tissue cultivation. The throughput, consistency of the tissue, and the potential integration of high-throughput automation are an advantage over other approaches. The tissues and the platform are validated using appropriate methodology to provide convincing evidence of the tissue cultivation capability.

   Reviewed by eLife

9. The natural tannins oligomeric proanthocyanidins and punicalagin are potent inhibitors of infection by SARS-CoV-2

   This article has 12 authors:

   1. Hsiao-Fan Chen
   2. Wei-Jan Wang
   3. Chung-Yu Chen
   4. Wei-Chao Chang
   5. Po-Ren Hsueh
   6. Shin-Lei Peng
   7. Chen-Shiou Wu
   8. Yeh Chen
   9. Hsin-Yu Huang
   10. Wan-Jou Shen
   11. Shao-Chun Wang
   12. Mien-Chie Hung

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental work provides preclinical evidence to support that natural tannins derived from grapeseed can inhibit or prevent infection by the SARS-CoV-2 viruses. The evidence provided is mostly solid to convincing and supports the conclusions. This work will be of broad interest to cell biologists and physicians.

   Reviewed by eLife

10. SNORD90 induces glutamatergic signaling following treatment with monoaminergic antidepressants

    This article has 28 authors:

    1. Rixing Lin
    2. Aron Kos
    3. Juan Pablo Lopez
    4. Julien Dine
    5. Laura M Fiori
    6. Jennie Yang
    7. Yair Ben-Efraim
    8. Zahia Aouabed
    9. Pascal Ibrahim
    10. Haruka Mitsuhashi
    11. Tak Pan Wong
    12. El Cherif Ibrahim
    13. Catherine Belzung
    14. Pierre Blier
    15. Faranak Farzan
    16. Benicio N Frey
    17. Raymond W Lam
    18. Roumen Milev
    19. Daniel J Muller
    20. Sagar V Parikh
    21. Claudio Soares
    22. Rudolf Uher
    23. Corina Nagy
    24. Naguib Mechawar
    25. Jane A Foster
    26. Sidney H Kennedy
    27. Alon Chen
    28. Gustavo Turecki

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is an important study that uncovers a new molecular pathway that links traditional monoaminergic antidepressants with regulation of glutamate neurotransmission. The data provided for the model are convincing and demonstrate the pathway in human plasma and brain, mouse brain, and cultured cells, using the relative strengths of each system. The work will be of interest to psychiatrists studying depression as well as basic neurobiologists interested in monoamine signaling in the brain.

    Reviewed by eLife