eLife

Latest preprint reviews

1. Acute stress reduces effortful prosocial behaviour

   This article has 9 authors:

   1. Paul AG Forbes
   2. Gökhan Aydogan
   3. Julia Braunstein
   4. Boryana Todorova
   5. Isabella C Wagner
   6. Patricia L Lockwood
   7. Matthew AJ Apps
   8. Christian C Ruff
   9. Claus Lamm

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports valuable findings on the influence of acute stress on prosocial behavior and its neural correlates. Though the evidence is generally solid, concerns about confounding and sampling bias detract from the potential impact.

   Reviewed by eLife

2. Live imaging of excitable axonal microdomains in ankyrin-G-GFP mice

   This article has 21 authors:

   1. Christian Thome
   2. Jan Maximilian Janssen
   3. Seda Karabulut
   4. Claudio Acuna
   5. Elisa D'Este
   6. Stella J Soyka
   7. Konrad Baum
   8. Michael Bock
   9. Nadja Lehmann
   10. Johannes Roos
   11. Nikolas A Stevens
   12. Masashi Hasegawa
   13. Dan A Ganea
   14. Chloé M Benoit
   15. Jan Gründemann
   16. Lia Y Min
   17. Kalynn M Bird
   18. Christian Schultz
   19. Vann Bennett
   20. Paul M Jenkins
   21. Maren Engelhardt

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable paper, the authors created a reporter mouse line in which the Axon Initial Segment (AIS) is intrinsically labeled by an ankyrin-G-GFP fusion protein activated by Cre recombinase, tagging the native Ank3 gene. Using confocal, superresolution, and two-photon microscopy as well as whole-cell patch-clamp recordings in vitro, ex vivo, and in vivo, the authors convincingly document that the subcellular scaffold of the AIS and electrophysiological parameters of labeled cells remain unchanged. They further uncover rapid AIS remodeling following increased network activity in this model system, as well as highly reproducible in vivo labeling of AIS over weeks.

   Reviewed by eLife

3. Sensory neurons couple arousal and foraging decisions in Caenorhabditis elegans

   This article has 2 authors:

   1. Elias Scheer
   2. Cornelia I Bargmann

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is an important study on how behavioral context affects decision making in the nematode C. elegans. Behavioral analyses at multiple time scales combined with genetic and neuronal manipulations revealed how arousal states affect decision making. The results and interpretations are convincing. This work will be of interest to both neuroscientists and ecologists.

   Reviewed by eLife

4. Network-level changes in the brain underlie fear memory strength

   This article has 2 authors:

   1. Josue Haubrich
   2. Karim Nader

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides convincing data in support of the conclusion that weak but not strong fear memories are more easily modified using behavioural and pharmacological approaches potentially as a result of differential connectivity with the amygdala showing greater connectivity through the brain in weak compared to strong memories. The scope of the paper would be strengthened if both sexes were examined and more varied definitions of weak vs. strong memories were used. This paper is of interest to behavioural and neuroscience researchers studying learning, memory, and/or neural networks.

   Reviewed by eLife

5. Linking the evolution of two prefrontal brain regions to social and foraging challenges in primates

   This article has 7 authors:

   1. Sebastien Bouret
   2. Emmanuel Paradis
   3. Sandrine Prat
   4. Laurie Castro
   5. Pauline Perez
   6. Emmanuel Gilissen
   7. Cecile Garcia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study correlates the size of various prefrontal brain regions in primate species with socioecological variables like foraging distance and population density. The evidence presented is solid but the approach and conclusions are limited to primates with well-defined gyri.

   Reviewed by eLife

6. A computationally informed comparison between the strategies of rodents and humans in visual object recognition

   This article has 4 authors:

   1. Anna Elisabeth Schnell
   2. Maarten Leemans
   3. Kasper Vinken
   4. Hans Op de Beeck

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Schnell et al report important differences between the strategies used by rodents and humans when discriminating different visual objects. The evidence supporting these findings is convincing, showing that rat performance was influenced far more by low-level cues compared to humans. It is, however, unclear to what extent these differences can be explained by the lower visual acuity of rats. This work will be of general interest to vision and cognition researchers, particularly those studying object vision.

   Reviewed by eLife

7. C-type natriuretic peptide improves maternally aged oocytes quality by inhibiting excessive PINK1/Parkin-mediated mitophagy

   This article has 12 authors:

   1. Hui Zhang
   2. Chan Li
   3. Qingyang Liu
   4. Jingmei Li
   5. Hao Wu
   6. Rui Xu
   7. Yidan Sun
   8. Ming Cheng
   9. Xiaoe Zhao
   10. Menghao Pan
   11. Qiang Wei
   12. Baohua Ma

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment:

     This study presents valuable findings on the impact of C-natriuretic peptide (CNP) treatment in vivo on the fertility of aged mice. Solid data indicate CNP induces the cAMP-PKA pathway, causing reduced recruitment of Parkin protein to mitochondria in oocytes, resulting in reduced mitophagy, which may be significant for increased mitochondrial bioenergetics and improved cytoplasmic and nuclear maturation. The authors make additional claims regarding the mechanisms by which CNP impacts oocyte quality in vivo for which the evidence is inconclusive. This work will be of interest to reproductive biologists and clinical infertility specialists.

   Reviewed by eLife

8. Ebola virus sequesters IRF3 in viral inclusion bodies to evade host antiviral immunity

   This article has 13 authors:

   1. Lin Zhu
   2. Jing Jin
   3. Tingting Wang
   4. Yong Hu
   5. Hainan Liu
   6. Ting Gao
   7. Qincai Dong
   8. Yanwen Jin
   9. Ping Li
   10. Zijing Liu
   11. Yi Huang
   12. Xuan Liu
   13. Cheng Cao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study explores how Ebola virus evades human immune responses. The study reports a potential new mechanism wherein Ebola virus traps human IRF3, a key transcription factor involved in immune signaling, into virus-produced "inclusion bodies". The topic is important, the paper has many merits, and the biochemical assays are solid. However, the current data do not clearly explain the relationship between the VP35 protein and IRF3.

   Reviewed by eLife

9. SIRT-1 is required for release of enveloped enteroviruses

   This article has 8 authors:

   1. Alagie Jassey
   2. James Logue
   3. Stuart Weston
   4. Michael A Wagner
   5. Ganna Galitska
   6. Katelyn Miller
   7. Matthew Frieman
   8. William T Jackson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The presence or absence of a surrounding envelope, previously a clear distinguishing feature of different viruses, has been blurred by the recent recognition that many so-called 'nonenveloped' viruses are released from cells as quasi-enveloped virions cloaked in host cell membranes. This mechanism of viral egress allows for non-lytic infection, and has potentially important implications for pathogenesis. In this manuscript, Jassey and colleagues provide solid evidence that the protein deacetylase SIRT-1 is required for the non-lytic release of enteroviruses in extracellular vesicles.

   Reviewed by eLife

10. Drosophila model to clarify the pathological significance of OPA1 in autosomal dominant optic atrophy

    This article has 8 authors:

    1. Yohei Nitta
    2. Jiro Osaka
    3. Ryuto Maki
    4. Satoko Hakeda-Suzuki
    5. Emiko Suzuki
    6. Satoshi Ueki
    7. Takashi Suzuki
    8. Atsushi Sugie

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study provides valuable insights into the complex genetics of dominant optic atrophy. Leveraging a fly model, the investigators provide solid evidence, albeit with small effect sizes, for a dominant negative mechanism of certain pathogenic variants that tend to cause more severe phenotypes, a long held hypothesis in the field. The work is of high interest to those in the optic atrophy and degeneration fields.

    Reviewed by eLife