eLife

Latest preprint reviews

1. A unified approach to dissecting biphasic responses in cell signaling

   This article has 2 authors:

   1. Vaidhiswaran Ramesh
   2. J Krishnan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a useful mathematical analysis of different signaling networks in an attempt to provide general rules that give rise to biphasic responses, a widely observed behavior in biology in which the outputs of the network depend non-monotonically on the inputs. Determining general conditions that underlie this behavior would be useful in engineering synthetic biological systems and for mechanistically understanding biphasic responses in biological systems. However, whereas the mathematical approach and methods are solid, as they stand, the analyses are inadequate to assess how these findings are applicable in nature and which are general.

   Reviewed by eLife

2. Apoptosis recognition receptors regulate skin tissue repair in mice

   This article has 14 authors:

   1. Olivia Justynski
   2. Kate Bridges
   3. Will Krause
   4. Maria Fernanda Forni
   5. Quan M Phan
   6. Teresa Sandoval-Schaefer
   7. Kristyn Carter
   8. Diane E King
   9. Henry C Hsia
   10. Michael I Gazes
   11. Steven D Vyce
   12. Ryan R Driskell
   13. Kathryn Miller-Jensen
   14. Valerie Horsley

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors studied the mechanisms by which dead cells are removed from the wounded skin in a process called efferocytosis. By analyzing different cell populations in the skin, the authors find that proteins involved in mediating the cell death and marking the cells as undergoing this process are elevated during distinct times in the wound healing program. Interestingly, these same proteins are elevated even higher in diabetic wounds. Finally the authors demonstrate that blocking the process of efferocytosis alters the wound healing program, thus illustrating its importance in effective wound repair.

   Reviewed by eLife

3. We couldn't get details of this article at this time:
   10.1101/2022.12.10.519922

4. We couldn't get details of this article at this time:
   10.1101/2022.12.05.519094

5. We couldn't get details of this article at this time:
   10.1101/2022.09.21.508824

6. We couldn't get details of this article at this time:
   10.1101/2023.03.05.531166

7. Cross-movie prediction of individualized functional topography

   This article has 5 authors:

   1. Guo Jiahui
   2. Ma Feilong
   3. Samuel A Nastase
   4. James V Haxby
   5. M Ida Gobbini

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study presents a tool for hyperaligning functional brain topography between individuals, which is based on fMRI connectivity data gathered when participants watched different movies. The tool is validated through strong correlations between functional topographic maps generated from a participant's own localizer data and those derived from other participants' data based on this hyperalignment, even when the training and target participants were drawn from different datasets. The study will potentially be of interest to researchers working with a wide range of fMRI datasets.

   Reviewed by eLife

8. BrainPy, a flexible, integrative, efficient, and extensible framework for general-purpose brain dynamics programming

   This article has 6 authors:

   1. Chaoming Wang
   2. Tianqiu Zhang
   3. Xiaoyu Chen
   4. Sichao He
   5. Shangyang Li
   6. Si Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The paper introduces a new, important framework for neural modelling that promises to offer efficient simulation and analysis tools for a wide range of biologically-realistic neural networks. The paper's examples provide solid support for the ease of use and flexibility of the framework, but the comparison to existing solutions (in particular in terms of accuracy and performance) is incomplete. With a more careful evaluation of the tool's strengths and limitations, the work would be of interest to a wide range of computational neuroscientists and researchers working on biologically inspired machine learning applications.

   Reviewed by eLife

9. Loss of finger control complexity and intrusion of flexor biases are dissociable in finger individuation impairment after stroke

   This article has 8 authors:

   1. Jing Xu
   2. Timothy Ma
   3. Sapna Kumar
   4. Kevin Olds
   5. Jeremy Brown
   6. Jacob Carducci
   7. Alex Forrence
   8. John Krakauer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study presents a new apparatus and experimental paradigm to examine deficits in finger control in stroke patients, with the goal of understanding their potential (biomechanical and neural) underpinnings. The paper presents solid experimental design and quantitative analyses to characterise these deficits and infer their origin, but a few technical aspects related to data analysis and statistics could be improved, and alternative interpretations of the results considered. In addition to the scientific results, this novel methodology can be used as a starting point for further research on hand function impairments in stroke, which is of significance for theoretical studies in neuroscience and applied research in rehabilitation.

   Reviewed by eLife

10. We couldn't get details of this article at this time:
    10.1101/2023.02.12.528218