eLife

Latest preprint reviews

1. MDverse, shedding light on the dark matter of molecular dynamics simulations

   This article has 12 authors:

   1. Johanna KS Tiemann
   2. Magdalena Szczuka
   3. Lisa Bouarroudj
   4. Mohamed Oussaren
   5. Steven Garcia
   6. Rebecca J Howard
   7. Lucie Delemotte
   8. Erik Lindahl
   9. Marc Baaden
   10. Kresten Lindorff-Larsen
   11. Matthieu Chavent
   12. Pierre Poulain

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study presents a valuable tool for searching molecular dynamics simulation data, making such datasets accessible for open science. The authors provide convincing evidence that it is possible to identify noteworthy molecular dynamics simulation datasets and that their analysis can produce information of value to the community.

   Reviewed by eLife

2. Heat stress impairs centromere structure and segregation of meiotic chromosomes in Arabidopsis

   This article has 7 authors:

   1. Lucie Crhak Khaitova
   2. Pavlina Mikulkova
   3. Jana Pecinkova
   4. Manikandan Kalidass
   5. Stefan Heckmann
   6. Inna Lermontova
   7. Karel Riha

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study is an important contribution to our insights into the impact of heat stress on sexual reproduction in plants and provides information about how centromere integrity is affected by heat stress during male meiosis in Arabidopsis thaliana. The evidence supporting the claims, specifically the dynamics of tagged proteins in meiocytes by live cell imaging is solid, even though a deeper mechanistic understanding is still lacking.

   Reviewed by eLife

3. Control of meiotic entry by dual inhibition of a key mitotic transcription factor

   This article has 3 authors:

   1. Amanda J Su
   2. Siri C Yendluri
   3. Elçin Ünal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study highlights several important regulatory pathways that contribute to the control of entry into meiosis by turning down mitotic functions. Central to this regulation is the control of Swi4 level and activity, and convincing overexpression experiments identify downstream effectors of Swi4.

   Reviewed by eLife

4. Regulation of multiple signaling pathways promotes the consistent expansion of human pancreatic progenitors in defined conditions

   This article has 12 authors:

   1. Luka Jarc
   2. Manuj Bandral
   3. Elisa Zanfrini
   4. Mathias Lesche
   5. Vida Kufrin
   6. Raquel Sendra
   7. Daniela Pezzolla
   8. Ioannis Giannios
   9. Shahryar Khattak
   10. Katrin Neumann
   11. Barbara Ludwig
   12. Anthony Gavalas

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study describes a method to decouple the mechanisms supporting pancreatic progenitor self-renewal and expansion from feed-forward mechanisms promoting their differentiation allowing in vitro expansion of hPSC-derived pancreatic progenitors. The strength of evidence is convincing in that the authors use appropriate and validated methodology in line with current state-of-the-art. The work will be of interest to the field of beta cell replacement therapy in diabetes.

   Reviewed by eLife

5. Nitric oxide feedback to ciliary photoreceptor cells gates a UV avoidance circuit

   This article has 7 authors:

   1. Kei Jokura
   2. Nobuo Ueda
   3. Martin Gühmann
   4. Luis Alfonso Yañez-Guerra
   5. Piotr Słowiński
   6. Kyle C. A. Wedgwood
   7. Gáspár Jékely

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study reports the discovery of a new circuit mechanism for light-avoidance behavior in the marine annelid, Platynereis dumerilii. Using calcium imaging, molecular perturbations, behavioral measurements, and modeling, the authors provide compelling evidence that nitric oxide is released by postsynaptic neurons onto ciliary photoreceptors to prolong and enhance their response to ultraviolet light. The fundamental new role of nitric oxide described in this study may be conserved across animal phyla and thus will be of broad interests to neuroscientists and neuroendocrinologists.

   Reviewed by eLife

6. The information bottleneck as a principle underlying multi-area cortical representations during decision-making

   This article has 10 authors:

   1. Michael Kleinman
   2. Tian Wang
   3. Derek Xiao
   4. Ebrahim Feghhi
   5. Kenji Lee
   6. Nicole Carr
   7. Yuke Li
   8. Nima Hadidi
   9. Chandramouli Chandrasekaran
   10. Jonathan C Kao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript reports a useful computational study of information encoding across the monkey prefrontal and pre-motor cortices during decision making. While many of the conclusions are supported with solid analyses, the evidence for the main interpretation of the results, the role of an information bottleneck across areas, is not complete. The results will be of interest to a systems and computational neuroscience audience.

   Reviewed by eLife

7. Loss of tumor suppressor TMEM127 drives RET-mediated transformation through disrupted membrane dynamics

   This article has 13 authors:

   1. Timothy J Walker
   2. Eduardo Reyes-Alvarez
   3. Brandy D Hyndman
   4. Michael G Sugiyama
   5. Larissa CB Oliveira
   6. Aisha N Rekab
   7. Mathieu JF Crupi
   8. Rebecca Cabral-Dias
   9. Qianjin Guo
   10. Patricia LM Dahia
   11. Douglas S Richardson
   12. Costin N Antonescu
   13. Lois M Mulligan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable paper provides convincing evidence that loss of the tumor suppressor TMEM127 causes disorganization of plasma membrane lipid domains, alters clathrin assembly, and inhibits endocytosis of a variety of cell surface receptors, leading to increased cell surface levels of signaling proteins including RET and other transmembrane receptor tyrosine kinases. The results are significant for understanding how RET127 loss contributes to pheochromocytoma, although the evidence is indirect owing to the lack of human pheochromocytoma cell lines. The results will be of interest for researchers studying pheochromocytoma and endocytosis mechanisms.

   Reviewed by eLife

8. The MODY-associated KCNK16 L114P mutation increases islet glucagon secretion and limits insulin secretion resulting in transient neonatal diabetes and glucose dyshomeostasis in adults

   This article has 11 authors:

   1. Arya Y Nakhe
   2. Prasanna K Dadi
   3. Jinsun Kim
   4. Matthew T Dickerson
   5. Soma Behera
   6. Jordyn R Dobson
   7. Shristi Shrestha
   8. Jean-Philippe Cartailler
   9. Leesa Sampson
   10. Mark A Magnuson
   11. David A Jacobson

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study characterizes how a point mutation in the TALK-1 potassium channel, encoded by the KCNK16 gene, causes MODY diabetes. The mutation, L114P, causes a gain-of-function to increase K+ currents and inhibit glucose-stimulated insulin secretion. Increased glucagon likely results from paracrine effects in the islets. The data are convincing and the work will be valuable for understanding islet function.

   Reviewed by eLife

9. Dual-color optical activation and suppression of neurons with high temporal precision

   This article has 12 authors:

   1. Noëmie Mermet-Joret
   2. Andrea Moreno
   3. Agnieszka Zbela
   4. Milad Nazari
   5. Bárður Eyjólfsson Ellendersen
   6. Raquel Comaposada Baro
   7. Nathalie Krauth
   8. Anne von Philipsborn
   9. Andreas Toft Sørensen
   10. Joaquin Piriz
   11. John Yu-luen Lin
   12. Sadegh Nabavi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study develops useful tools for distinct optogenetic control of neuronal activity by red or blue light. The basic characterization of the activation of a red-shifted channelrhodopsin paired with a blue-light sensitive anion channel engineered to obtain desired inhibitory current kinetics is solid. However, evidence for their practical use under simultaneous multi-color or high frequency stimulation in cells are missing.

   Reviewed by eLife

10. A maximum of two readily releasable vesicles per docking site at a cerebellar single active zone synapse

    This article has 3 authors:

    1. Melissa Silva
    2. Van Tran
    3. Alain Marty

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      The study used slice physiology and modeling to investigate neurotransmitter release at the cerebellar parallel fiber-to-molecular layer interneuron synapse, revealing that each docking site can accommodate up to two synaptic vesicles simultaneously. The evidence presented is convincing. These important findings validate a two-step docking model and shed light on the mechanisms underlying short-term synaptic plasticity and strategies for achieving synaptic reliability, which plays a critical role in information processing in the brain.

    Reviewed by eLife