eLife

Latest preprint reviews

1. Cis-regulatory modes of Ultrabithorax inactivation in butterfly forewings

   This article has 7 authors:

   1. Amruta Tendolkar
   2. Anyi Mazo-Vargas
   3. Luca Livraghi
   4. Joseph J Hanly
   5. Kelsey C Van Horne
   6. Lawrence E Gilbert
   7. Arnaud Martin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable paper examines the Bithorax complex in several butterfly species, in which the complex is contiguous and not split, as it is in the well-studied fruit fly Drosophila. Based on genetic screens and genetic manipulations of a boundary element involved in segment-specific regulation of Ubx, the authors provide convincing evidence for their conclusions, which could be strengthened by additional data and analyses in the future. The data presented are relevant for those interested in the evolution and function of Hox genes and of gene regulation in general.

   Reviewed by eLife

2. Matrix-associated extracellular vesicles modulate human smooth muscle cell adhesion and directionality by presenting collagen VI

   This article has 26 authors:

   1. Alexander N Kapustin
   2. Sofia Serena Tsakali
   3. Meredith Whitehead
   4. George Chennell
   5. Meng-Ying Wu
   6. Chris Molenaar
   7. Anton Kutikhin
   8. Yimeng Chen
   9. Sadia Ahmad
   10. Leo Bogdanov
   11. Maxim Sinitsky
   12. Kseniya Rubina
   13. Aled Clayton
   14. Frederik J Verweij
   15. Dirk Michiel Pegtel
   16. Simona Zingaro
   17. Arseniy Lobov
   18. Bozhana Zainullina
   19. Dylan Owen
   20. Maddy Parsons
   21. Richard E Cheney
   22. Derek T Warren
   23. Martin James Humphries
   24. Thomas Iskratsch
   25. Mark Holt
   26. Catherine M Shanahan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This paper explores the role of extracellular vesicles in providing extracellular matrix signals for migration of vascular smooth muscle cells. The evidence, based on cell culture experiments and supporting imaging of human samples, is mostly convincing. The paper will be valuable for researchers investigating cell migration during vessel repair and atherogenesis.

   Reviewed by eLife

3. A binding site for phosphoinositides described by multiscale simulations explains their modulation of voltage-gated sodium channels

   This article has 4 authors:

   1. Yiechang Lin
   2. Elaine Tao
   3. James P Champion
   4. Ben Corry

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study employs multiscale simulations to show that PIP2 lipids bind to DIV S4-S5 linkers within the inactivated state of a voltage-gated sodium channel, affecting the coupling of voltage sensors to the ion-conducting pore. The authors demonstrate that PIP2 prolongs inactivation by binding to the same site that binds the C-terminal during recovery from inactivation, and they suggest that binding to gating charges in the resting state may impede activation, both findings that contribute to our understanding of sodium channel modulation. The coarse-grained and atomistic molecular dynamics simulations are convincing, including state dependence and linker mutants to back up the claims.

   Reviewed by eLife

4. Spatial and temporal distribution of ribosomes in single cells reveals aging differences between old and new daughters of Escherichia coli

   This article has 4 authors:

   1. Lin Chao
   2. Chun Kuen Chan
   3. Chao Shi
   4. Ulla Camilla Rang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study is a potentially important contribution to the field of protein biosynthesis pathways and their link to aging, especially regarding the thorough analysis of variation in measures expected to correlate with elongation rate in old and new daughter cells derived from old and new mother cells. However, the imaging results, analysis, and methodologies are incomplete, as in its current form several key questions remain unanswered.

   Reviewed by eLife

5. Efficient estimation for large-scale linkage disequilibrium patterns of the human genome

   This article has 6 authors:

   1. Xin Huang
   2. Tian-Neng Zhu
   3. Ying-Chao Liu
   4. Guo-An Qi
   5. Jian-Nan Zhang
   6. Guo-Bo Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable new approach for efficient computation of statistics on correlations between genetic variants (linkage disequilibrium, or LD), which the authors apply to quantify the extent of LD across chromosomes. The method appears solid, although the presentation of equations needs clarification and improvement. The authors document that cross-chromosome LD can be substantial, which has implications for geneticists who are interested in population structure and its impact on genetic association studies.

   Reviewed by eLife

6. Interplay between charge distribution and DNA in shaping HP1 paralog phase separation and localization

   This article has 4 authors:

   1. Tien M Phan
   2. Young C Kim
   3. Galia T Debelouchina
   4. Jeetain Mittal

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study substantially advances our understanding of molecular mechanisms driving the phase separation behavior of HP1 paralogs. The evidence supporting the conclusions is convincing, with rigorous and well-designed computational simulations. The work will be of broad interest to biophysicists and biochemists.

   Reviewed by eLife

7. Tracing the substrate translocation mechanism in P-glycoprotein

   This article has 13 authors:

   1. Theresa Gewering
   2. Deepali Waghray
   3. Kristian Parey
   4. Hendrik Jung
   5. Nghi NB Tran
   6. Joel Zapata
   7. Pengyi Zhao
   8. Hao Chen
   9. Dovile Januliene
   10. Gerhard Hummer
   11. Ina Urbatsch
   12. Arne Moeller
   13. Qinghai Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     P-glycoprotein is a major ABC-transporter that exports drugs used in chemotherpay and effects the pharmacokinetics of other drugs. Here the authors have determined cryo-EM structures of drug complexes in previously unforeseen outward-facing conformations. These convincing findings are mechanistically important and reveal potential regions to be exploited by rational-based drug design.

   Reviewed by eLife

8. Design of the HPV-automated visual evaluation (PAVE) study: Validating a novel cervical screening strategy

   This article has 19 authors:

   1. Silvia de Sanjosé
   2. Rebecca B Perkins
   3. Nicole Campos
   4. Federica Inturrisi
   5. Didem Egemen
   6. Brian Befano
   7. Ana Cecilia Rodriguez
   8. Jose Jerónimo
   9. Li C Cheung
   10. Kanan Desai
   11. Paul Han
   12. Akiva P Novetsky
   13. Abigail Ukwuani
   14. Jenna Marcus
   15. Syed Rakin Ahmed
   16. Nicolas Wentzensen
   17. Jayashree Kalpathy-Cramer
   18. Mark Schiffman
   19. On behalf of the PAVE Study Group

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study will provide evidence about a novel screen-triage-treat strategy for cervical cancer prevention. The trial will generate convincing evidence regarding the efficacy, effectiveness, cost-effectiveness, feasibility and acceptability in a range of geographically spread low-resource settings. The strategy should contribute to improving access to cervical cancer prevention to vulnerable women with low access to health care, and, therefore, at the highest risk of cervical cancer.

   Reviewed by eLife

9. Elimination of subtelomeric repeat sequences exerts little effect on telomere essential functions in Saccharomyces cerevisiae

   This article has 7 authors:

   1. Can Hu
   2. Xue-Ting Zhu
   3. Ming-Hong He
   4. Yangyang Shao
   5. Zhongjun Qin
   6. Zhi-Jing Wu
   7. Jin-Qiu Zhou

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study advances our understanding of the biological significance of the DNA sequence adjacent to telomeres. The data presented convincingly demonstrate that subtelomeric repeats are non-essential and have a minimal, if any, role in maintaining telomere integrity of budding yeast. The work will be of interest to the telomere community specifically and the genome integrity community more broadly.

   Reviewed by eLife

10. Intermittent fasting promotes type 3 innate lymphoid cells secreting IL-22 contributing to the beigeing of white adipose tissue

    This article has 10 authors:

    1. Hong Chen
    2. Lijun Sun
    3. Lu Feng
    4. Xue Han
    5. Yunhua Zhang
    6. Wenbo Zhai
    7. Zehe Zhang
    8. Michael Mulholland
    9. Weizhen Zhang
    10. Yue Yin

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study provides valuable findings showing the production of IL-22 from intestinal ILC3 during intermittent fasting promotes beigeing of white adipose tissue. The authors provided solid data and mechanistic insight by which IL-22-derived from ILC3 directly induces beigeing.

    Reviewed by eLife