eLife

Latest preprint reviews

1. Iron chelation improves ineffective erythropoiesis and iron overload in myelodysplastic syndrome mice

   This article has 10 authors:

   1. Wenbin An
   2. Maria Feola
   3. Maayan Levy
   4. Srinivas Aluri
   5. Marc Ruiz-Martinez
   6. Ashwin Sridharan
   7. Eitan Fibach
   8. Xiaofan Zhu
   9. Amit Verma
   10. Yelena Ginzburg

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents a valuable finding that erythrocyte precursors could re-gain EPO responsiveness after DFP chelation therapy. In addition, the authors investigated iron trafficking in erythroblasts using the MDS mouse model. However, the evidence supporting the claims of the authors is still inadequate. The work will be of interest to medical biologists working on hematology.

   Reviewed by eLife

2. On the computational principles underlying human exploration

   This article has 3 authors:

   1. Lior Fox
   2. Ohad Dan
   3. Yonatan Loewenstein

3. The antigenic landscape of human influenza N2 neuraminidases from 2009 until 2017

   This article has 19 authors:

   1. João Paulo Portela Catani
   2. Anouk Smet
   3. Tine Ysenbaert
   4. Marnik Vuylsteke
   5. Guy Bottu
   6. Janick Mathys
   7. Alexander Botzki
   8. Guadalupe Cortes-Garcia
   9. Tod Strugnell
   10. Raul Gomila
   11. John Hamberger
   12. John Catalan
   13. Irina V Ustyugova
   14. Timothy Farrell
   15. Svetlana Stegalkina
   16. Satyajit Ray
   17. Lauren LaRue
   18. Xavier Saelens
   19. Thorsten U Vogel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents valuable data on the antigenic properties of neuraminidase proteins of human A/H3N2 influenza viruses sampled between 2009 and 2017. The antigenic properties are found to be generally concordant with genetic groups. Compared to a previous version, additional analyses have strengthened the work, with solid evidence supporting the claims of the authors.

   Reviewed by eLife

4. Morphology and ultrastructure of external sense organs of Drosophila larvae

   This article has 9 authors:

   1. Vincent Richter
   2. Anna Rist
   3. Georg Kislinger
   4. Michael Laumann
   5. Andreas Schoofs
   6. Anton Miroschnikow
   7. Michael J Pankratz
   8. Albert Cardona
   9. Andreas S Thum

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The manuscript from Richter et al. is a very thorough anatomical description of the external sensory organs in Drosophila larvae. It represents a fundamental step forward for sensory physiology, and provides a tool for investigating the relationship between the structure and function of sensory organs. Using improved electron microscopy analysis and digital modelling, the authors provide compelling evidence that form the basis for further molecular and functional studies to decipher the sensory strategies used by larvae to navigate through their environment.

   Reviewed by eLife

5. Transformation of valence signaling in a mouse striatopallidal circuit

   This article has 4 authors:

   1. Donghyung Lee
   2. Nathan Lau
   3. Lillian Liu
   4. Cory M Root

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study by Lee and colleagues examined how neural representations are transformed between the olfactory tubercle (OT) and the ventral pallidum (VP) using single neuron calcium imaging in head-fixed mice trained in classical conditioning. They show that the dimensionality of neural responses is lower in the VP than in the OT and suggest that VP responses represent values in a more abstract form at the single neuron level while OT contains more odor information, potentially enhancing odor contrast. The results are overall convincing and this study provides insights into how odor information is transformed in the olfactory system.

   Reviewed by eLife

6. Theta cycle dynamics of spatial representations in the lateral septum

   This article has 2 authors:

   1. Katarzyna Bzymek
   2. Fabian Kloosterman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, the authors present convincing evidence to demonstrate theta cycle skipping by individual neurons of the lateral septum, which they then relate to population coding of future trajectories encapsulated by theta cycles. This valuable finding furthers our understanding of how the septum conveys navigational information downstream.

   Reviewed by eLife

7. Updating the sulcal landscape of the human lateral parieto-occipital junction provides anatomical, functional, and cognitive insights

   This article has 4 authors:

   1. Ethan H Willbrand
   2. Yi-Heng Tsai
   3. Thomas Gagnant
   4. Kevin S Weiner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The present work provides new insights into detailed brain morphology. Using state-of-the-art methods, it provides compelling evidence for the relevance of sucal morphology for the precise localization of brain function. The fundamental findings have great relevance for the fields of imaging neuroscience and individualized medicine as ever-improving techniques improve precision to the point where individual brain anatomy is taking centre stage.

   Reviewed by eLife

8. Neurophysiological trajectories in Alzheimer’s disease progression

   This article has 12 authors:

   1. Kiwamu Kudo
   2. Kamalini G Ranasinghe
   3. Hirofumi Morise
   4. Faatimah Syed
   5. Kensuke Sekihara
   6. Katherine P Rankin
   7. Bruce L Miller
   8. Joel H Kramer
   9. Gil D Rabinovici
   10. Keith Vossel
   11. Heidi E Kirsch
   12. Srikantan S Nagarajan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This work presents important findings for the field of Alzheimer's disease, especially for the electrophysiology subfield, by investigating the temporal evolution of different disease stages typically reported using M/EEG markers of resting-state brain activity. The evidence supporting the conclusions is convincing and the methodology as well as the descriptions of the processes are of high quality, although a separation of individuals who are biomarker positive versus negative would have strengthened the results and conclusions of the study.

   Reviewed by eLife

9. Cerebellar nuclei cells produce distinct pathogenic spike signatures in mouse models of ataxia, dystonia, and tremor

   This article has 4 authors:

   1. Meike E van der Heijden
   2. Amanda M Brown
   3. Dominic J Kizek
   4. Roy V Sillitoe

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The authors' dataset and analysis provide a fundamental new understanding of how cerebellar output contributes to various cerebellar-dependent diseases. The observation that different firing statistics at the level of the cerebellar nuclei directly impart disease-specific phenotypes is quite convincing. The classifier used in the manuscript remains a potential weak-point, showing limited efficacy, particularly for identifying mice with tremor. The concern about classifier accuracy is ameliorated by the fact that the classifier parameters are easily interpretable, and allowed the authors to use these parameters to design stimulation experiments.

   Reviewed by eLife

10. Representational drift as a result of implicit regularization

    This article has 3 authors:

    1. Aviv Ratzon
    2. Dori Derdikman
    3. Omri Barak

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents a new and important theoretical account of spatial representational drift in the hippocampus. The evidence supporting the claims is convincing, with a clear and accessible explanation of the phenomenon. Overall, this study will likely attract researchers exploring learning and representation in both biological and artificial neural networks.

    Reviewed by eLife