eLife

Latest preprint reviews

1. Id2 GABAergic interneurons comprise a neglected fourth major group of cortical inhibitory cells

   This article has 11 authors:

   1. Robert Machold
   2. Shlomo Dellal
   3. Manuel Valero
   4. Hector Zurita
   5. Ilya Kruglikov
   6. John Hongyu Meng
   7. Jessica L Hanson
   8. Yoshiko Hashikawa
   9. Benjamin Schuman
   10. György Buzsáki
   11. Bernardo Rudy

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a valuable contribution to the effort to provide genetic access to and characterization of the major classes of interneurons in the mammalian neocortex. The authors develop an improved strategy for intersectionally targeting a fourth (and final) major category of diverse interneurons in the mouse, including the previously studied neurogliaform cells. They provide a detailed characterization of these cells and show convincingly that their genetic strategy can be used to identify and manipulate these cells, both in vitro and in vivo.

   Reviewed by eLife

2. Scavenger receptor endocytosis controls apical membrane morphogenesis in the Drosophila airways

   This article has 5 authors:

   1. Ana Sofia Pinheiro
   2. Vasilios Tsarouhas
   3. Kirsten André Senti
   4. Badrul Arefin
   5. Christos Samakovlis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this important study, the authors present evidence for the novel involvement of a scavenger receptor in tubular morphogenesis. Using a convincing set of data, the authors propose that the Drosophila scavenger receptor Emp (homologous to human CD36 ) couples endocytosis of luminal molecules and regulates tube length via controlling Crumbs and Src. This work will be of broad interest to cell and development biologists as well as cancer biologists.

   Reviewed by eLife

3. Manganese-enhanced magnetic resonance imaging reveals light-induced brain asymmetry in embryo

   This article has 4 authors:

   1. Elena Lorenzi
   2. Stefano Tambalo
   3. Giorgio Vallortigara
   4. Angelo Bifone

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript is important as it showed an establishment of a method for looking a neuronal activity in embryos which can support the previously reported laterality in chick thalamofugal system. However, the evidence the author provided was incomplete as no actual data was provided.

   Reviewed by eLife

4. Divergent regulation of KCNQ1/E1 by targeted recruitment of protein kinase A to distinct sites on the channel complex

   This article has 6 authors:

   1. Xinle Zou
   2. Sri Karthika Shanmugam
   3. Scott A Kanner
   4. Kevin J Sampson
   5. Robert S Kass
   6. Henry M Colecraft

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides a substantial advance with a method by which a protein target resistant to therapeutic approaches can be uniquely modulated by a cellular protein kinase ferried by nanobodies to a precise molecular site of recruitment. Evidence for this major claim is compelling, but evidence for some of the minor claims seems incomplete. The work will be of broad interest to cell biologists, cardiovascular researchers, and drug developers.

   Reviewed by eLife

5. Using multi-modal neuroimaging to characterise social brain specialisation in infants

   This article has 8 authors:

   1. Maheen Siddiqui
   2. Paola Pinti
   3. Sabrina Brigadoi
   4. Sarah Lloyd-Fox
   5. Clare E Elwell
   6. Mark H Johnson
   7. Ilias Tachtsidis
   8. Emily JH Jones

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides a state-of-the-art framework to explore the coupling of complementary cerebral measures (neural, hemodynamic, and metabolic) during development by providing an interesting roadmap for multimodal neuroimaging in infants. The methodological contribution is compelling with an original setup for simultaneous EEG and NIRS recording and solid data analyses. However, the claims about functional specialization and the role of the temporal-parietal junction in social processing are only partially supported by the results. This work will be of interest to a broad audience of scientists interested in multimodal neuroimaging and cognitive development.

   Reviewed by eLife

6. CD8+ tissue-resident memory T cells induce oral lichen planus erosion via cytokine network

   This article has 11 authors:

   1. Maofeng Qing
   2. Dan Yang
   3. Qianhui Shang
   4. Jiakuan Peng
   5. Jiaxin Deng
   6. Jiang Lu
   7. Jing Li
   8. HongXia Dan
   9. Yu Zhou
   10. Hao Xu
   11. Qianming Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Overall, this is an important study that characterizes human oral lichen planus via single-cell analysis. Although the work is descriptive, it can represent an important resource for future studies and highlights potentially relevant biology. However, the claims are a bit overstated and some of the analyses that lead to interpretations remain incomplete.

   Reviewed by eLife

7. Fin whale song evolution in the North Atlantic

   This article has 17 authors:

   1. Miriam Romagosa
   2. Sharon Nieukirk
   3. Irma Cascão
   4. Tiago A Marques
   5. Robert Dziak
   6. Jean-Yves Royer
   7. Joanne O'Brien
   8. David K Mellinger
   9. Andreia Pereira
   10. Arantza Ugalde
   11. Elena Papale
   12. Sofia Aniceto
   13. Giuseppa Buscaino
   14. Marianne Rasmussen
   15. Luis Matias
   16. Rui Prieto
   17. Mónica A Silva

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study is a valuable contribution to our understanding of vocal variation in acoustic displays of male baleen whales, part of a developing story about cultural change in songs in species other than the relatively well studied humpback whales. The authors present solid evidence of changes at various timescales in 20-Hz song note intervals and call center frequency over decadal time scales and large spatial scales.

   Reviewed by eLife

8. Folding of prestin’s anion-binding site and the mechanism of outer hair cell electromotility

   This article has 6 authors:

   1. Xiaoxuan Lin
   2. Patrick R Haller
   3. Navid Bavi
   4. Nabil Faruk
   5. Eduardo Perozo
   6. Tobin R Sosnick

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents important findings regarding the local dynamics at the anion binding site in the SLC26 transporter prestin that is responsible for electromotility in outer hair cells. The authors reveal critical differences to homologous proteins and thereby provide insight into prestin's unique function. The evidence is generally convincing, although orthogonal evidence would be required to fully support the claims concerning the mechanistic basis for voltage sensitivity.

   Reviewed by eLife

9. Disentangled multi-subject and social behavioral representations through a constrained subspace variational autoencoder (CS-VAE)

   This article has 5 authors:

   1. Daiyao Yi
   2. Simon Musall
   3. Anne Churchland
   4. Nancy Padilla-Coreano
   5. Shreya Saxena

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This paper is a valuable step in multi-subject behavioral modeling using an extension of the Variational Autoencoder (VAE) framework. Using a novel partition of the latent space and in tandem with a recently proposed regularization scheme, the paper provides a rich set of computational analyses analyzing social behavior data of mice with results that represent the state-of-the-art in this subfield. The strength of evidence is convincing, with the methodology being well documented and the results being reproducible, although some additional quantifications would have been helpful to fully gauge the circumstances where the approach would be most effectively applied.

   Reviewed by eLife

10. EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS

    This article has 16 authors:

    1. Mark W Urban
    2. Brittany A Charsar
    3. Nicolette M Heinsinger
    4. Shashirekha S Markandaiah
    5. Lindsay Sprimont
    6. Wei Zhou
    7. Eric V Brown
    8. Nathan T Henderson
    9. Samantha J Thomas
    10. Biswarup Ghosh
    11. Rachel E Cain
    12. Davide Trotti
    13. Piera Pasinelli
    14. Megan C Wright
    15. Matthew B Dalva
    16. Angelo C Lepore

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is a valuable study of Eph-Ephrin signaling mechanisms generating pathological changes in amyotropic lateral sclerosis. There are exciting findings bearing on the role of glial cells in this pathology. The study emerges with solid evidence for a novel astrocyte-mediated mechanism for disease propagation. It may help identify potential therapeutic targets.

    Reviewed by eLife