eLife

Latest preprint reviews

1. Developmental oligodendrocytes regulate brain function through the mediation of synchronized spontaneous activity

   This article has 4 authors:

   1. Ryo Masumura
   2. Kyosuke Goda
   3. Mariko Sekiguchi
   4. Naofumi Uesaka

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable manuscript, authors ablate cerebellar oligodendrocytes during postnatal development and show that synchrony of calcium transients in Purkinje neurons and behaviours are affected even at later stages. While the work is solid, it is incomplete in that the causal relationship between the two has not been sufficiently explored.

   Reviewed by eLife

2. Detecting Regime Shifts: Neurocomputational Substrates for Over- and Underreactions to Change

   This article has 3 authors:

   1. Mu-Chen Wang
   2. George Wu
   3. Shih-Wei Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides valuable insights into the behavioral, computational, and neural mechanisms of regime shift detection, by identifying distinct roles for the frontoparietal network and ventromedial prefrontal cortex in sensitivity to signal diagnosticity and transition probabilities, respectively. The findings are supported by solid evidence, including an innovative task design, robust behavioral modeling, and well-executed model-based fMRI analyses, though claims of neural selectivity would benefit from more rigorous statistical comparisons. Overall, this work advances our understanding of how humans adapt belief updating in dynamic environments and offers a framework for exploring biases in decision-making under uncertainty.

   Reviewed by eLife

3. Neuronal Detection Triggers Systemic Digestive Shutdown in Response to Adverse Food Sources

   This article has 8 authors:

   1. Yating Liu
   2. Guojing Tian
   3. Ziyi Wang
   4. Junkang Zheng
   5. Huimin Liu
   6. Sucheng Zhu
   7. Zhao Shan
   8. Bin Qi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates how signals from the nervous system can influence the response to different food sources. To demonstrate the role of specific neuronal and intestinal regulators in sensing food quality and modulating digestion, the authors present evidence through a combination of genetic screening, RNA-seq analysis, and functional studies. While the findings shed light on an adaptive strategy to integrate food perception with physiological responses, the evidence presented varies between convincing and incomplete, and additional experiments are needed to more fully support their central hypothesis.

   Reviewed by eLife

4. Changes in large-scale neural networks under stress are linked to affective reactivity to stress in real life

   This article has 7 authors:

   1. Rayyan Tutunji
   2. Martin Krentz
   3. Nikos Kogias
   4. Lycia de Voogd
   5. Florian Krause
   6. Eliana Vassena
   7. Erno J Hermans

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study examines the effects of acute social stress on brain function, focusing on dynamic shifts in large-scale networks such as the salience and default mode networks. It highlights a robust association between stress-induced changes in salience network activation and stress reactivity in daily life, although evidence linking brain function changes following acute stress to real-life stress is incomplete. The findings are significant for stress biology research and could influence future studies on stress responses.

   Reviewed by eLife

5. Late killing of Plasmodium berghei sporozoites in the liver by an anti-circumsporozoite protein antibody

   This article has 8 authors:

   1. Manuela C Aguirre-Botero
   2. Olga Pacios
   3. Susanna Celli
   4. Eduardo Aliprandini
   5. Anisha Gladston
   6. Jean-Michel Thiberge
   7. Pauline Formaglio
   8. Rogerio Amino

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that a monoclonal antibody against the repetitive region of the circumsporozoite protein (CSP) of the Malaria-causing parasite P. berghei has neutralizing activity on parasite invasion and development. The authors present convincing in vivo data confirming previous in vitro work, that suggested the intracellular post -invasion effect for this antibody. The findings offer insights into the inhibitory action of this anti-CSP antibody, which could inform the development of more effective malaria vaccines and therapeutic antibodies."

     [Editors' note: this paper was reviewed by Review Commons.]

   Reviewed by eLife, Review Commons

6. Food intake enhances hippocampal sharp wave-ripples

   This article has 6 authors:

   1. Ekin Kaya
   2. Evan Wegienka
   3. Alexandra Akhtarzandi-Das
   4. Hanh Do
   5. Ada Eban-Rothschild
   6. Gideon Rothschild

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study assessed the effects of food intake on sharp wave-ripples in the hippocampus of mice during subsequent sleep. Convincing evidence supports the conclusion that sharp wave-ripples are enhanced by food consumption. This work will likely interest researchers studying multiple functions including memory, metabolism, and brain-body physiology.

   Reviewed by eLife

7. Therapeutic benefits of maintaining CDK4/6 inhibitors and incorporating CDK2 inhibitors beyond progression in breast cancer

   This article has 6 authors:

   1. Jessica Armand
   2. Sungsoo Kim
   3. Kibum Kim
   4. Eugene Son
   5. Minah Kim
   6. Hee Won Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents fundamental insights into overcoming resistance in hormone receptor-positive breast cancer by demonstrating that sustained CDK4/6 inhibitor treatment, either alone or in combination with CDK2 inhibitors, significantly suppresses the growth of drug-resistant cancer cells. The findings are supported by compelling evidence from both in vitro cell line experiments and in vivo mouse models, highlighting the therapeutic potential of maintaining CDK4/6 inhibitors beyond disease progression. Additionally, the identification of cyclin E overexpression as a key driver of resistance offers a target that will be of value for future therapeutic strategies, potentially improving outcomes for patients with advanced breast cancer.

   Reviewed by eLife

8. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/gf7mr

9. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/vbtzq

10. Strip cropping in organic agriculture results in 15% higher ground beetle richness and 30% higher activity density than monocultures

    This article has 6 authors:

    1. Luuk Croijmans
    2. Fogelina Cuperus
    3. Dirk F. van Apeldoorn
    4. Felix J.J.A. Bianchi
    5. Walter A.H. Rossing
    6. Erik H. Poelman

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study shows that strip cropping -- planting different crops in strips on the same field -- enhances the taxonomic diversity of ground beetles relative to corresponding monocultures in multiple experiments with different crops in the Netherlands. While these findings are important for demonstrating the potential beneficial effects of this form of intercropping, the information presented is incomplete with regard to sampling design and data obtained.

    Reviewed by eLife