Latest preprint reviews

  1. Stemness factor Mex3a times translation and protein trafficking to ensure robust differentiation of olfactory sensory neurons

    This article has 13 authors:
    1. Martín Escamilla del Arenal
    2. Lauren C Tang
    3. Albana Kodra
    4. Hani Shayya
    5. Aileen Ugurbil
    6. Olga Stathi
    7. Keskin Abdurrahman
    8. Adan Horta
    9. Joan Pulupa
    10. Junqiang Ye
    11. Marko Jovanovic
    12. Stavros Lomvardas
    13. Rachel Duffié
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This important study identified Mex3a protein with dual RNA-binding protein/ubiquitin ligase function as a pivotal regulator of olfactory sensory neurons (OSN) differentiation and lineage fidelity. The authors employed a combination of systems biology approaches (e.g., single-cell RNA sequencing, proteomics) and newly developed animal models (e.g., HyperTRIBE) to provide solid evidence that abrogation of Mex3a disrupts cilia structure and polarity of OSNs. Notwithstanding that this article is of a broad potential interest across different biomedical disciplines ranging from RNA to developmental biology, additional mechanistic data connecting identified Mex3a mRNA targets and ensuing OSN phenotypes would further strengthen this study.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Platelets promote acute liver injury via extracellular vesicles-mediated Aldolase A

    This article has 9 authors:
    1. Ruoxue Yang
    2. Jinghua Liu
    3. Kai Fu
    4. Ting Wan
    5. Yahui Li
    6. Can Shen
    7. Ling Yang
    8. Keqin Wang
    9. Zhao Shan
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      In this useful manuscript, Yang et al attempt to show that platelet recruitment to the liver via macrophages contributes to APAP-induced liver injury, but there were many areas where the data supporting the conclusions were incomplete. For example, the idea that platelets only affected KC glycolysis, but not the metabolism of other cells, to mediate the phenotype after injury is not adequately supported by the evidence. It is recommended to perform additional experiments to strengthen the conclusions.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. The role of MICOS in organizing mitochondrial cristae in malaria parasites

    This article has 9 authors:
    1. Silvia Tassan-Lugrezin
    2. Irina Bregy
    3. Judith López Orra
    4. Nicholas I Proellochs
    5. Geert-Jan van Gemert
    6. Rianne Stoter
    7. Felix Evers
    8. Taco WA Kooij
    9. Laura van Niftrik
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides valuable insights into mitochondrial cristae organization in Plasmodium falciparum, particularly in the context of its divergent MICOS composition. The authors present convincing evidence, supported by phenotypic and morphological analyses, that cristae junction maintenance can be uncoupled from de novo cristae formation, reinforcing an emerging model of mitochondrial inner membrane organization. Notably, the absence of Mic10 alongside an enlarged and divergent MICOS complex highlights an intriguing evolutionary adaptation, although further characterization of the complex would strengthen the study's overall significance.

      [Editors' note: this paper was reviewed by Review Commons.]

    Reviewed by eLife, Review Commons

    This article has 9 evaluationsAppears in 2 listsLatest version Latest activity
  4. Regulation of sphingolipid synthesis by the C2H2 zinc finger transcription factor Com2 through ubiquitin-proteasome mediated degradation pathway

    This article has 12 authors:
    1. Kosei Matsumoto
    2. Ayane Nagai
    3. Nao Komatsu
    4. Yuko Ishino
    5. Rina Shirai
    6. Toshiya Ueno
    7. Mio Masaki
    8. Ken-taro Sakata
    9. Motohiro Tani
    10. Tatsuya Maeda
    11. Naotaka Tanaka
    12. Mitsuaki Tabuchi
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study provides valuable insights into how cells maintain sphingolipid homeostasis through transcriptional control and regulated protein degradation in response to changes in sphingolipid levels. The evidence supporting the conclusions is convincing overall, with solid genetic and biochemical approaches, while some mechanistic aspects remain to be clarified. This work will be of interest to researchers studying lipid metabolism and membrane biology.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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