eLife

Latest preprint reviews

1. Systematic characterization of site-specific proline hydroxylation using hydrophilic interaction chromatography and mass spectrometry

   This article has 7 authors:

   1. Hao Jiang
   2. Jimena Druker
   3. James W Wilson
   4. Dalila Bensaddek
   5. Jason R Swedlow
   6. Sonia Rocha
   7. Angus I Lamond

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The study presents a valuable resource of proline hydroxylation proteins for molecular biology studies in oxygen-sensing and cell signaling with the characterization of Repo-man proline hydroxylation site. The evidence supporting the claim of the authors is solid, although further clarification of the overall efficiency of the HILIC analysis, the specificity/sensitivity of immonium ion analysis, as well as quantification of proline hydroxylation identifications will be helpful. The work will be of interest to researchers studying post-translational modification, oxygen sensing, and cell signaling.

   Reviewed by eLife

2. Acidocalcisome-like vacuoles constitute a feedback-controlled phosphate buffering system for the cytosol

   This article has 6 authors:

   1. Samuel Bru
   2. Lydie Michaillat Mayer
   3. Geun-Don Kim
   4. Danye Qiu
   5. Henning J Jessen
   6. Andreas Mayer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides fundamental insights into eukaryotic phosphate homeostasis by demonstrating how yeast vacuoles dynamically regulate cytosolic phosphate levels. The conclusions are convincing, supported by an elegant combination of in vitro assays and in vivo measurements. This study will be of interest to cell biologists, particularly for those who are working in the field of phosphate metabolism.

   Reviewed by eLife

3. Structural insights into the recruitment of viral Type 2 IRES to ribosomal preinitiation complex for protein synthesis

   This article has 2 authors:

   1. Deepakash Das
   2. Tanweer Hussain

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript offers valuable structural and mechanistic insights into the structure and assembly of the Type II internal ribosome entry site (IRES) from encephalomyocarditis virus (EMCV) and the translation initiation complex, revealing a direct interaction between the IRES and the 40S ribosomal subunit. While a solid cryo-EM method was used, enhancing the overall resolution or adding complementary biochemical data would further improve the clarity and impact of this study. This manuscript will attract researchers in cap-independent translation, host-pathogen interactions, and virology.

   Reviewed by eLife

4. Task structure tailors the geometry of neural representations in human lateral prefrontal cortex

   This article has 4 authors:

   1. Apoorva Bhandari
   2. Haley Keglovits
   3. Defne Buyukyazgan
   4. David Badre

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable finding on the representational structure of task encoding in the prefrontal cortex. The evidence supporting the claims of the authors is solid, representing an impressive data collection effort and best-practice fMRI analyses. However, at least including visual regions as a control and controlling for behavioral differences in the task in representation analyses would have strengthened the study. The work will be of interest to cognitive neuroscientists interested in the neural basis of cognitive control.

   Reviewed by eLife

5. Dynamics of mesoscale brain network during decision-making learning revealed by chronic, large-scale single-unit recording

   This article has 5 authors:

   1. Tian-Yi Wang
   2. Chengcong Feng
   3. Chengyao Wang
   4. Chi Ren
   5. Zhengtuo Zhao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents experiments suggesting intriguing mesoscale reorganization of functional connectivity across distributed cortical and subcortical circuits during learning. The approach is technically impressive and the results are potentially of valuable significance. However, in its current form, the strength of evidence is incomplete. More in-depth analyses and the acquisition of data from additional animals in the primary experiment could bolster these findings.

   Reviewed by eLife

6. Coordinated dynamics of excitatory and inhibitory synapse assembly

   This article has 3 authors:

   1. Krassimira Garbett
   2. James Allen
   3. Richard C Sando

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable study, the authors developed long-term imaging tools to simultaneously monitor the temporal and spatial dynamics of excitatory and inhibitory synapses and reported that excitatory and inhibitory synapses need to develop synergistically during synaptogenesis to maintain balance. While the analysis and quantification of the imaging data are incomplete, there is convincing evidence that the developed tools are feasible. If these tools can function stably in vivo, their applications will be much broader.

   Reviewed by eLife

7. Heterogenous associations of polygenic indices of 35 traits with mortality

   This article has 7 authors:

   1. Hannu Lahtinen
   2. Jaakko Kaprio
   3. Andrea Ganna
   4. Kaarina Korhonen
   5. Stefano Lombardi
   6. Karri Silventoinen
   7. Pekka Martikainen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study reports convincing evidence about associations between 35 polygenic indices (PGIs) for social, behavioral, and psychological traits, along with some non-fatal health conditions (e.g., BMI) and all-cause mortality in data from Finnish population-based surveys and a twin cohort linked with administrative registers. PGIs for education, depression, alcohol use, smoking, BMI, and self-rated health showed the strongest associations with all-cause mortality, on the order of ~10% increment in risk per PGI standard deviation. Effect sizes from twin-difference analyses tended to be slightly larger than the effect sizes from population cohorts, opposite the pattern generally observed when testing PGI associations with their target phenotypes and supporting robustness of findings to confounding by population stratification.

   Reviewed by eLife

8. Visual Working Memory Guides Attention Rhythmically

   This article has 3 authors:

   1. Jiachen Lu
   2. Yaochun Cai
   3. Xilin Zhang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study reports evidence that items maintained in working memory can bias attention in an oscillatory manner, with the attentional capture effect fluctuating at theta frequency. The study provides incomplete evidence that this dynamic attentional bias is associated with oscillatory neural mechanisms, particularly in the alpha and theta bands, as measured by EEG. The study will be relevant for researchers studying attention, working memory, and neural oscillations, particularly those interested in how memory and perception interact over time.

   Reviewed by eLife

9. A Context-Free Model of Savings in Motor Learning

   This article has 4 authors:

   1. Mahdiyar Shahbazi
   2. Olivier Codol
   3. Jonathan A Michaels
   4. Paul L Gribble

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents valuable computational findings on the neural basis of learning new motor memories and the savings using recurrent neural networks. The evidence supporting the claims of the authors is solid, but it would benefit from more controls and from considering the role of explicit strategies and other brain regions. This work will be of interest to computational and experimental neuroscientists working in motor learning.

   Reviewed by eLife

10. Feedback of peripheral saccade targets to early foveal cortex

    This article has 5 authors:

    1. Luca Kämmer
    2. Lisa M Kroell
    3. Tomas Knapen
    4. Martin Rolfs
    5. Martin N Hebart

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study addresses a question related to how we achieve visual stability across saccadic eye movements. The authors' gaze-contingent fMRI design provides convincing evidence that peripherally presented visual stimuli are represented in foveal visual cortex prior to a saccade. The results will be of interest to vision scientists and behavioural neuroscientists.

    Reviewed by eLife