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  1. Pial collaterals develop through mosaic colonization of capillaries by arterial and microvascular endothelial cells

    This article has 7 authors:
    1. Tijana Perovic
    2. Irene Hollfinger
    3. Stefanie Mayer
    4. Janet Lips
    5. Monika Dopatka
    6. Christoph Harms
    7. Holger Gerhardt
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This study provides insights into the developmental origin of endothelial cells found in blood vessels called pial collaterals. The work is important, as collateral capacity can strongly influence the trajectory of outcomes with vascular blockage, and the approaches are novel and overall convincing; however, some mechanistic claims are only partially supported, and collateral characterization is incomplete. Given the clear positive correlation between pial collateral flow and improved stroke outcome, this study will be of interest to vascular biologists and clinicians caring for stroke patients.

    Reviewed by eLife

    This article has 5 evaluationsAppears in 1 listLatest version Latest activity
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