eLife

Latest preprint reviews

1. FMNL2 regulates actin for endoplasmic reticulum and mitochondria distribution in oocyte meiosis

   This article has 10 authors:

   1. Meng-Hao Pan
   2. Kun-Huan Zhang
   3. Si-Le Wu
   4. Zhen-Nan Pan
   5. Ming-Hong Sun
   6. Xiao-Han Li
   7. Jia-Qian Ju
   8. Shi-Ming Luo
   9. Xiang-Hong Ou
   10. Shao-Chen Sun

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents useful findings regarding the role of formin-like 2 in mouse oocyte meiosis. Some of the data are supported by incomplete methodological details and analyses, and several conclusions are overstated. This paper would be of interest to reproductive biologists.

   Reviewed by eLife

2. Inhibition of miR-199b-5p reduces pathological alterations in osteoarthritis by potentially targeting Fzd6 and Gcnt2

   This article has 11 authors:

   1. Tong Feng
   2. Qi Zhang
   3. Si-Hui Li
   4. Yan-ling Ping
   5. Mu-qiu Tian
   6. Shuan-hu Zhou
   7. Xin Wang
   8. Jun-Meng Wang
   9. Fan-Rang Liang
   10. Shu-Guang Yu
   11. Qiao-Feng Wu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study reports that miR-199b-5p is elevated in human osteoarthritis patients. There is solid evidence for the finding that inhibiting miR-199b-5p alleviates symptoms in mice with knee osteoarthritis. Additionally, potential targets of miR-199b-5p are identified but whether miR-199b-5p truly functions through Fzd6 and/or Gcnt2 requires further investigation.

   Reviewed by eLife

3. Developmental conversion of thymocyte-attracting cells into self-antigen-displaying cells in embryonic thymus medulla epithelium

   This article has 12 authors:

   1. Izumi Ohigashi
   2. Andrea J White
   3. Mei-Ting Yang
   4. Sayumi Fujimori
   5. Yu Tanaka
   6. Alison Jacques
   7. Hiroshi Kiyonari
   8. Yosuke Matsushita
   9. Sevilay Turan
   10. Michael C Kelly
   11. Graham Anderson
   12. Yousuke Takahama

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study provides new insights into the development and function of medullary thymus epithelial cells (mTEC). The authors provide compelling evidence to support their claims as to the differentiation and lineage outcomes of CCL21+ mTEC progenitors, which further our understanding of how central tolerance of T cells is enforced within the thymus.

   Reviewed by eLife

4. Liver microRNA transcriptome reveals miR-182 as link between type 2 diabetes and fatty liver disease in obesity

   This article has 19 authors:

   1. Christin Krause
   2. Jan H Britsemmer
   3. Miriam Bernecker
   4. Anna Molenaar
   5. Natalie Taege
   6. Nuria Lopez-Alcantara
   7. Cathleen Geißler
   8. Meike Kaehler
   9. Katharina Iben
   10. Anna Judycka
   11. Jonas Wagner
   12. Stefan Wolter
   13. Oliver Mann
   14. Paul Pfluger
   15. Ingolf Cascorbi
   16. Hendrik Lehnert
   17. Kerstin Stemmer
   18. Sonja C Schriever
   19. Henriette Kirchner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Building on on the observation of an increase in miR-182-5p in diabetic patients, the authors investigated the role of miR-182-5p and its target gene LRP6 in dysregulated glucose tolerance and fatty acid metabolism in obese type 2 diabetics. The use of human livers complemented by supporting data in mice and cells are strengths, but the evidence presented remains incomplete. The findings provide valuable insights into the role of miRNAs in the regulation of liver metabolism and insulin sensitivity in individuals with diabetes and fatty liver disease.

   Reviewed by eLife

5. The evolution of transposable elements in Brachypodium distachyon is governed by purifying selection, while neutral and adaptive processes play a minor role

   This article has 4 authors:

   1. Robert Horvath
   2. Nikolaos Minadakis
   3. Yann Bourgeois
   4. Anne C Roulin

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study seeks to disentangle the different selective forces shaping the evolutionary dynamics of transposable elements (TEs) in the wild grass Brachypodium distachyon. Using haplotype-length metrics, and genetic and environmental differentiation tests, the authors present convincing evidence that positive selection on TE polymorphisms is rare and that the distribution of TE ages points to purifying selection being the main force acting on TE evolution in this species. This study will be relevant for anyone interested in the role of TEs in evolution and adaptation.

   Reviewed by eLife

6. Divergent folding-mediated epistasis among unstable membrane protein variants

   This article has 10 authors:

   1. Laura M Chamness
   2. Charles P Kuntz
   3. Andrew G McKee
   4. Wesley D Penn
   5. Christopher M Hemmerich
   6. Douglas B Rusch
   7. Hope Woods
   8. Dyotima
   9. Jens Meiler
   10. Jonathan P Schlebach

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study describes exhaustive deep mutational scanning (DMS) of the gonadotropin-releasing hormone wild-type receptor and for two single point mutations that impact its folding and structure, monitoring how plasma membrane expression levels are influenced by the introduced mutations. With solid evidence, the authors have pioneered an exploration of the interaction between mutations (epistasis) in a membrane protein, with a potential for explaining membrane protein evolution and genetic diseases.

   Reviewed by eLife

7. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2306.03218v2

8. An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis

   This article has 5 authors:

   1. J Barney Bryson
   2. Alexandra Kourgiantaki
   3. Dai Jiang
   4. Andreas Demosthenous
   5. Linda Greensmith

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study presents a method to restore muscle innervations in ALS mouse models using optogenetics. It is convincing that embryonic stem cell derived motor neurons can be transplanted into and applied to reinnervate the muscles in an ALS mouse model. The work will be of broad interest to researchers and medical biologists to develop new strategies for the treatment of neurodegenerative disorders resulting from denervated skeletal muscles.

   Reviewed by eLife

9. Growth inhibitory factor/metallothionein-3 is a sulfane sulfur-binding protein

   This article has 13 authors:

   1. Yasuhiro Shinkai
   2. Yunjie Ding
   3. Toru Matsui
   4. George Devitt
   5. Masahiro Akiyama
   6. Tang-Long Shen
   7. Motohiro Nishida
   8. Tomoaki Ida
   9. Takaaki Akaike
   10. Sumeet Mahajan
   11. Jon M Fukuto
   12. Yasuteru Shigeta
   13. Yoshito Kumagai

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable work provides solid evidence that a neuronal metallothionein, GIF/MT-3, incorporates metal-persulfide clusters. A variety of well-designed assays support the authors' hypothesis, revealing that sulfane sulfur is released from MT-3. However, the sufane sulfur content in the canonical induced MT-1 and MT-2 has not been demonstrated. Thus, the biological role of the persulfidated form is not yet clearly defined. There are caveats to the findings that limit the study, but the work will nevertheless prompt major follow-up work.

   Reviewed by eLife

10. Open-top Bessel beam two-photon light sheet microscopy for three-dimensional pathology

    This article has 7 authors:

    1. Won Yeong Park
    2. Jieun Yun
    3. Jinho Shin
    4. Byung Ho Oh
    5. Gilsuk Yoon
    6. Seung-Mo Hong
    7. Ki Hean Kim

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This important work by Park et al. demonstrates an open-top two-photon light sheet microscopy (OT-TP-LSM) for lesser invasive evaluation of intraoperative 3D pathology. The authors provide convincing evidence for the effectiveness of this technique investigating various human cancer cells. This article will be of broad interest to biologists and, specifically, pathologists utilizing 3D optical microscopy.

    Reviewed by eLife