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10. Export of discarded splicing intermediates requires mRNA export factors and the nuclear basket

    This article has 2 authors:

    1. Yi Zeng
    2. Jonathan P. Staley

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This is an important study that demonstrates that RNA intermediates arising from improper splicing are exported out of the nucleus via the canonical mRNA export machinery and the nuclear pore basket. The authors provide convincing evidence that the role of the nuclear basket rather than retaining the transcripts is stimulating their export, putting into question the current model of the role of the basket. The conclusions are in line with recent studies in mammalian cells that suggest that the basket's role in mRNA export and quality control has to be revised.

    Reviewed by eLife