eLife

Latest preprint reviews

1. Inhibition of the UFD-1-NPL-4 complex triggers an aberrant immune response in Caenorhabditis elegans

   This article has 3 authors:

   1. Rajneesh Rao
   2. Alejandro Aballay
   3. Jogender Singh

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this valuable manuscript, Rao and colleagues investigate the UFD-1/NPL-4 complex, which is involved in extracting misfolded proteins in the plasma membrane and the accumulation of pathogenic bacteria in the intestine. Using convincing methods, the authors find that knockdown of the ufd-1 and npl-4 genes leads to shortened lifespan of the nematode C. elegans and reduced accumulation of the bacterial pathogen P. aeruginosa in the intestine.

   Reviewed by eLife

2. Chromosome structure in Drosophila is determined by boundary pairing not loop extrusion

   This article has 8 authors:

   1. Xinyang Bing
   2. Wenfan Ke
   3. Miki Fujioka
   4. Amina Kurbidaeva
   5. Sarah Levitt
   6. Mike Levine
   7. Paul Schedl
   8. James B Jaynes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work presents elegant experimental data from the Drosophila embryo supporting the notion that interactions among specific loci, called boundary elements, contribute to topologically associated domain (TAD) formation and gene regulation. The evidence supporting boundary:boundary pairing as a determinant of 3D structures is compelling; however, an inability to deplete loop extruders formally leaves open a possible contribution of loop extrusion. This study will be of interest to the nuclear structure community, particularly those using Drosophila as a model.

   Reviewed by eLife

3. Structure of scavenger receptor SCARF1 and its interaction with lipoproteins

   This article has 14 authors:

   1. Yuanyuan Wang
   2. Fan Xu
   3. Guangyi Li
   4. Chen Cheng
   5. Bowen Yu
   6. Ze Zhang
   7. Dandan Kong
   8. Fabao Chen
   9. Yali Liu
   10. Zhen Fang
   11. Longxing Cao
   12. Yang Yu
   13. Yijun Gu
   14. Yongning He

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     SCARF1 is a scavenger membrane-bound receptor that binds modified versions of lipoproteins and has a significant role in maintaining lipid homeostasis. This useful study reports the crystal structure of SCARF1 and identifies putative binding sites for modified lipoproteins. Supported by a convincing set of experimental approaches, this study advances our knowledge of how scavenger receptors clear modified lipoproteins to maintain lipid homeostasis.

   Reviewed by eLife

4. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2301.00759v2

5. Hemodynamics regulate spatiotemporal artery muscularization in the developing circle of Willis

   This article has 6 authors:

   1. Siyuan Cheng
   2. Ivan Fan Xia
   3. Renate Wanner
   4. Javier Abello
   5. Amber N Stratman
   6. Stefania Nicoli

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides the first analysis of vascular stabilization on the critical and evolutionarily conserved structure around the Circle of Willis in the brain, strengthened by using parallel in vivo and in vitro experimental approaches. The evidence supporting the claims is solid and the work will be valuable for scientists studying developmental and disease-related vascular stabilization.

   Reviewed by eLife

6. The non-mitotic role of HMMR in regulating the localization of TPX2 and the dynamics of microtubules in neurons

   This article has 4 authors:

   1. Yi-Ju Chen
   2. Shun-Cheng Tseng
   3. Peng-Tzu Chen
   4. Eric Hwang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In their valuable study, Chen et al. investigate the neuronal role of HMMR, a microtubule-associated protein typically associated with cell division. Their findings indicate that HMMR is necessary for proper neuronal morphology and the generation of polymerizing microtubules within neurites, potentially by promoting the function of TPX2. This solid body of work is the first step in deciphering the influence of a mitotic microtubule-associated protein in organizing microtubules in neurons and will be of interest to the neurobiology and cytoskeleton fields.

   Reviewed by eLife

7. Rtf1-dependent transcriptional pausing regulates cardiogenesis

   This article has 11 authors:

   1. Adam D Langenbacher
   2. Fei Lu
   3. Luna Tsang
   4. Zi Yi Stephanie Huang
   5. Benjamin Keer
   6. Zhiyu Tian
   7. Alette Eide
   8. Matteo Pellegrini
   9. Haruko Nakano
   10. Atsushi Nakano
   11. Jau-Nian Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that a controlled pause in gene reading is required for early heart cells to form during development. The authors demonstrate that loss of this pause prevents the proper activation of the heart-producing program across animal and stem cell systems. The evidence is compelling, supported by careful genomic and functional analyses that clearly define the developmental block. Overall, this work will interest developmental biologists and inspire further studies on the origins of early heart defects.

   Reviewed by eLife

8. Biocalcification in porcelaneous foraminifera

   This article has 8 authors:

   1. Zofia Dubicka
   2. Jarosław Tyszka
   3. Agnieszka Pałczyńska
   4. Michelle Höhne
   5. Jelle Bijma
   6. Max Jense
   7. Nienke Klerks
   8. Ulf Bickmeyer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript provides important information on the calcification process, especially the properties and formation of freshly formed tests (the foraminiferan shells), in the miliolid foraminiferan species Pseudolachlanella eburnea. The evidence from the high-quality SEM images is convincing although the fluorescence images only provide indirect support for the calcification process.

   Reviewed by eLife

9. Human pannexin 1 channel is not phosphorylated by Src tyrosine kinase at Tyr199 and Tyr309

   This article has 5 authors:

   1. Zheng Ruan
   2. Junuk Lee
   3. Yangyang Li
   4. Juan Du
   5. Wei Lü

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The current manuscript re-examines an established claim in the literature that human PANX-1 is regulated by Src kinase phosphorylation at two tyrosine residues, Y199 and Y309. This issue is important for our understanding of Pannexin channel regulation. The authors present an extensive series of experiments that fail to detect PANX-1 phosphorylation at these sites. Although the authors' approach is more rigorous than the previous studies, this work relies primarily on negative results that are not unambiguously definitive; the work nonetheless provides a compelling reason for the field to reexamine conclusions drawn in earlier studies.

   Reviewed by eLife

10. Human DCP1 is crucial for mRNA decapping and possesses paralog-specific gene regulating functions

    This article has 8 authors:

    1. Ting-Wen Chen
    2. Hsiao-Wei Liao
    3. Michelle Noble
    4. Jing-Yi Siao
    5. Yu-Hsuan Cheng
    6. Wei-Chung Chiang
    7. Yi-Tzu Lo
    8. Chung-Te Chang

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study attempts to understand the functional roles of the human DCP1 paralogs in regulating RNA decay by DCP2. Using a combination of cellular-based assays and in vitro assays, the authors conclude that DCP1a/b plays a role in regulating DCP2 activity. While this revised version presents some new and interesting observations on human DCP1, the underlying data to support its claims remain incomplete. Overall, these results will be useful to the RNA community.

    Reviewed by eLife