eLife

Latest preprint reviews

1. Discovering non-additive heritability using additive GWAS summary statistics

   This article has 7 authors:

   1. Samuel Pattillo Smith
   2. Gregory Darnell
   3. Dana Udwin
   4. Julian Stamp
   5. Arbel Harpak
   6. Sohini Ramachandran
   7. Lorin Crawford

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study provides a valuable investigation into whether phenotypic variance due to interactions between genetic variants can be measured using genome-wide association summary statistics. The authors present a method, i-LDSC, that uses statistics on the correlations between genotypes at different loci (linkage disequilibrium) to estimate the phenotypic variance explained by both additive genetic effects and pairwise interactions. While the authors present extensive simulations on the performance of their method and empirical results indicating the presence of epistasis (as they define epistasis) it is unclear how their method and results relate to the traditional definitions of additive and non-additive genetic effects, which are different from the authors' definitions.

   Reviewed by eLife

2. The title and authors for this article are not available from our external data provider yet:
   10.31219/osf.io/preprints/osf

3. Enabling brain-wide mapping of layer-specific functional connectivity at 3T via layer-dependent fMRI with draining-vein suppression

   This article has 3 authors:

   1. Wei-Tang Chang
   2. Weili Lin
   3. Kelly S Giovanello

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study presents a possible solution for a significant problem - that of draining vein sensitivity in functional MRI, which complicates the interpretability of laminar-fMRI results. The addition of a low diffusion-weighted gradient is presented to remove the draining vein signal and obtain functional responses with higher spatial fidelity. However, the strength of the evidence is incomplete, and most tests appear to have been done only in a single subject. Significance thresholds in presented maps are very low and most cortical depth-dependent response profiles do not differ from baseline, even in the BOLD data shown as reference. Curiously, even BOLD group data fails to replicate the well-known pattern of draining towards the cortical surface.

   Reviewed by eLife

4. Causal role of the frontal eye field in attention-induced ocular dominance plasticity

   This article has 7 authors:

   1. Fangxing Song
   2. Xue Dong
   3. Jiaxu Zhao
   4. Jue Wang
   5. Xiaohui Sang
   6. Xin He
   7. Min Bao

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study combines psychophysics, fMRI, and TMS to reveal a causal role of FEF in generating an attention-induced ocular dominance shift, with potential relevance for clinical applications. The evidence supporting the claims of the authors is convincing. The work will be of broad interest to perceptual and cognitive neuroscience.

   Reviewed by eLife

5. UGGT1-mediated reglucosylation of N-glycan competes with ER-associated degradation of unstable and misfolded glycoproteins

   This article has 18 authors:

   1. Satoshi Ninagawa
   2. Masaki Matsuo
   3. Deng Ying
   4. Shuichiro Oshita
   5. Shinya Aso
   6. Kazutoshi Matsushita
   7. Mai Taniguchi
   8. Akane Fueki
   9. Moe Yamashiro
   10. Kaoru Sugasawa
   11. Shunsuke Saito
   12. Koshi Imami
   13. Yasuhiko Kizuka
   14. Tetsushi Sakuma
   15. Takashi Yamamoto
   16. Hirokazu Yagi
   17. Koichi Kato
   18. Kazutoshi Mori

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important manuscript demonstrates that UGGT1 is involved in preventing the premature degradation of endoplasmic reticulum (ER) glycoproteins through the re-glucosylation of their N-linked glycans following release from the calnexin/calreticulin lectins. The authors include a wealth of convincing data in support of their findings, although extending these findings to other types of substrates, such as secreted proteins, could further demonstrate the global importance of this mechanism for protein trafficking through the secretory pathway. This work will be of interest to scientists interested in ER protein quality control, proteostasis, and protein trafficking.

   Reviewed by eLife

6. On the pH-dependence of α-synuclein amyloid polymorphism and the role of secondary nucleation in seed-based amyloid propagation

   This article has 11 authors:

   1. Lukas Frey
   2. Dhiman Ghosh
   3. Bilal M Qureshi
   4. David Rhyner
   5. Ricardo Guerrero-Ferreira
   6. Aditya Pokharna
   7. Witek Kwiatkowski
   8. Tetiana Serdiuk
   9. Paola Picotti
   10. Roland Riek
   11. Jason Greenwald

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents important findings on the different polymorphs of alpha-synuclein filaments that form at various pH's during in vitro assembly reactions with purified recombinant protein. Of particular note is the discovery of two new polymorphs (1M and 5A) that form in PBS buffer at pH 7. The strength of the evidence presented is convincing. The work will be of interest to biochemists and biophysicists working on protein aggregation and amyloids.

   Reviewed by eLife

7. The archerfish uses motor adaptation in shooting to correct for changing physical conditions

   This article has 3 authors:

   1. Svetlana Volotsky
   2. Opher Donchin
   3. Ronen Segev

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study showed convincing evidence that archerfishes can adapt their shooting behaviors to airflow perturbations. The fish also exhibits adaptive behaviors indicative of an egocentric representation of the perturbation, though direct evidence is missing. Hence, this work will be of interest to those interested in cross-species comparisons for motor learning.

   Reviewed by eLife

8. Homeostatic regulation of rapid eye movement sleep by the preoptic area of the hypothalamus

   This article has 10 authors:

   1. John J Maurer
   2. Alexandra Lin
   3. Xi Jin
   4. Jiso Hong
   5. Nicholas Sathi
   6. Romain Cardis
   7. Alejandro Osorio-Forero
   8. Anita Lüthi
   9. Franz Weber
   10. Shinjae Chung

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study advances our understanding of the brain nuclei involved in rapid-eye movement (REM) sleep regulation. Using a combination of imaging, electrophysiology, and optogenetic tools, the study provides convincing evidence that inhibitory neurons in the preoptic area of the hypothalamus influence REM sleep. This work will be of interest to neurobiologists working on the brain circuits of sleep.

   Reviewed by eLife

9. Multisensory integration operates on correlated input from unimodal transient channels

   This article has 2 authors:

   1. Cesare V Parise
   2. Marc O Ernst

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study evaluates a model for multisensory correlation detection, focusing on the detection of correlated transients in visual and auditory stimuli. Overall, the experimental design is sound and the evidence is compelling. The synergy between the experimental and theoretical aspects of the paper is strong, and the work will be of interest to both neuroscientists and psychologists working in the domain of sensory processing and perception.

   Reviewed by eLife

10. Fear conditioning biases olfactory sensory neuron expression across generations

    This article has 9 authors:

    1. Clara W Liff
    2. Yasmine R Ayman
    3. Eliza CB Jaeger
    4. Avery Cardeiro
    5. Hudson S Lee
    6. Alexis Kim
    7. Angélica V Albarracín
    8. Dianne-Lee KD Ferguson
    9. Bianca J Marlin

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides solid evidence that odor fear conditioning biases olfactory sensory neuron receptor choice in mice and that this bias is detectable in the next generation. The authors use rigorous histological and behavioral analyses, including unsupervised behavioral quantification, to support the conclusion that odor-specific sensory representations can be shaped by experience and partially transmitted across generations. While the behavioral effects in offspring are modest and the mechanistic basis of inheritance remains unresolved, the study offers an important and carefully executed contribution to understanding experience-dependent sensory plasticity and its intergenerational consequences.

    Reviewed by eLife