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  1. Scalable, optically-responsive human neuromuscular junction model reveals convergent mechanisms of synaptic dysfunction in familial ALS

    This article has 5 authors:
    1. Daniel Chen
    2. Polyxeni Philippidou
    3. Bianca de Freitas Brenha
    4. Ashleigh E. Schaffer
    5. Helen C. Miranda
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This is an important study describing a neuromuscular junction co-culture system using human cells that the authors use to study the synaptic consequences of ALS mutations. The data supporting the system are solid and show the value of using myotubes and motor neurons from the same donor. The study will be of interest to researchers who model neuromuscular junction disorders, however, the authors could more comprehensively compare and contrast their system with previous literature describing other similar models. There are also technical weaknesses that limit the interpretation of specific findings.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
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