Latest preprint reviews

  1. Novel 3D Approach to Model Non-Alcoholic Fatty Liver Disease using human Pluripotent Stem Cells

    This article has 18 authors:
    1. Carola Maria Morell
    2. Samantha Grace Tilson
    3. Rute Alexandra Tomaz
    4. Arash Shahsavari
    5. Andi Munteanu
    6. Giovanni Canu
    7. Brandon Tyler Wesley
    8. Marion Perrin
    9. Imbisaat Geti
    10. Subhankar Mukhopadhyay
    11. Francesca Mazzacuva
    12. Paul Gissen
    13. Jose Garcia-Bernardo
    14. Martin Bachman
    15. Casey Allison Rimland
    16. Fotios Sampaziotis
    17. Irina Mohorianu
    18. Ludovic Vallier
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      The authors present an important study of a multi-cellular platform involving co-culturing of various hiPSC-derived hepatocyte like cells, cholangiocytes, stellate cells and macrophages to mimic the liver microenvironment. The aggregates are then treated with fatty acids and examined through transcriptomic and functional assays. The techniques and methodologically are sound, and the evidence supporting the conclusion is convincing, although more clinically relevant data demonstrating the effect of some potential pharmacological agents on the platform would serve to strengthen the study.

    Reviewed by eLife

    This article has 3 evaluationsAppears in 1 listLatest version Latest activity
Newer Page 313 of 870 Older