eLife

Latest preprint reviews

1. A novel bivalent interaction mode underlies a non-catalytic mechanism for Pin1-mediated protein kinase C regulation

   This article has 7 authors:

   1. Xiao-Ru Chen
   2. Karuna Dixit
   3. Yuan Yang
   4. Mark I McDermott
   5. Hasan Tanvir Imam
   6. Vytas A Bankaitis
   7. Tatyana I Igumenova

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Pin1 as an essential prolyl cis/trans isomerase has attracted considerable attention because this enzyme family is implicated in cancer and neurodegenerative diseases. However, the requirement for its catalytic function remains a matter of dispute. The authors provide solid evidence that Pin1 modulates the activity of an important cell signaling kinase, Protein Kinase C, by a non-catalytic mechanism, acting as a chaperone to regulate the stability of this kinase.

   Reviewed by eLife

2. The Genetic Architecture of Dietary Iron Overload and Associated Pathology in Mice

   This article has 30 authors:

   1. Brie K. Fuqua
   2. Lambda Moses
   3. Stela McLachlan
   4. Calvin Pan
   5. Richard C. Davis
   6. Simon T. Hui
   7. Nam Che
   8. Zhiqiang Zhou
   9. Carmen Ng
   10. Sarada Charugundla
   11. Montgomery Blencowe
   12. Zara Saleem
   13. Aika Miikeda
   14. Beyza Ozdemir
   15. Chester Hui
   16. Thy Li
   17. Clara L. Stolin
   18. Marianne Kozuch
   19. Jie Zhou
   20. Kathryn Page
   21. Hiro Irimagawa
   22. Nam Ku
   23. Kodi Taraszka
   24. Nathan LaPierre
   25. David W. Killilea
   26. David M. Frazer
   27. Xia Yang
   28. Eleazar Eskin
   29. Chris D. Vulpe
   30. Aldons J. Lusis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This manuscript presents a detailed phenotyping of the role of dietary iron in a large number of genetically distinct mouse strains. There are exciting and convincing data that could be valuable in their impact on the fields of nutrition, iron metabolism and anemia.

   Reviewed by eLife

3. Emergence of brain-like mirror-symmetric viewpoint tuning in convolutional neural networks

   This article has 5 authors:

   1. Amirhossein Farzmahdi
   2. Wilbert Zarco
   3. Winrich A Freiwald
   4. Nikolaus Kriegeskorte
   5. Tal Golan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This computational study is a valuable empirical investigation into the common trait of neurons in brains and artificial neural networks: responding effectively to both objects and their mirror images and it focuses on uncovering conditions that lead to mirror symmetry in visual networks and the evidence convincingly demonstrates that learning contributes to expanding mirror symmetry tuning, given its presence in the data. Additionally, the paper delves into the transformation of face patches in primate visual hierarchy, shifting from view specificity to mirror symmetry to view invariance. It empirically analyzes factors behind similar effects in two network architectures, and key claims highlight the emergence of invariances in architectures with spatial pooling, driven by learning bilateral symmetry discrimination and importantly, these effects extend beyond faces, suggesting broader relevance. Despite strong experiments, some interpretations lack explicit support, and the paper overlooks pre-training emergence of mirror symmetry.

   Reviewed by eLife

4. Prediction error determines how memories are organized in the brain

   This article has 5 authors:

   1. Nicholas GW Kennedy
   2. Jessica C Lee
   3. Simon Killcross
   4. R Fred Westbrook
   5. Nathan M Holmes

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This is a fundamental study examining the role of prediction error in state allocation of memories. The data provided are convincing and largely support the conclusion that a gradual change between acquisition and extinction maintains the memory state of acquisition and thus results in extinction that is resistant to restoration. This paper is of interest to behavioural and neuroscience researchers studying learning, memory, and the neural mechanisms of those processes as well as to clinicians using extinction-based therapies in treating anxiety-based disorders

   Reviewed by eLife

5. Plural molecular and cellular mechanisms of pore domain KCNQ2 encephalopathy

   This article has 25 authors:

   1. Timothy J Abreo
   2. Emma C Thompson
   3. Anuraag Madabushi
   4. Kristen L Park
   5. Heun Soh
   6. Nissi Varghese
   7. Carlos G Vanoye
   8. Kristen Springer
   9. Jim Johnson
   10. Scotty Sims
   11. Zhigang Ji
   12. Ana G Chavez
   13. Miranda J Jankovic
   14. Bereket Habte
   15. Aamir R Zuberi
   16. Cathleen M Lutz
   17. Zhao Wang
   18. Vaishnav Krishnan
   19. Lisa Dudler
   20. Stephanie Einsele-Scholz
   21. Jeffrey L Noebels
   22. Alfred L George
   23. Atul Maheshwari
   24. Anastasios Tzingounis
   25. Edward C Cooper

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The paper investigates a potential cause of a type of severe epilepsy that develops in early life because of a defect in a gene called KCNQ2. The significance is fundamental because it substantially advances our understanding of a major research question. The strength of the evidence is convincing because appropriate methods are used that are in line with the state-of-the art.

   Reviewed by eLife

6. Decoding the complexity of delayed wound healing following Enterococcus faecalis infection

   This article has 6 authors:

   1. Cenk Celik
   2. Stella Tue Ting Lee
   3. Frederick Reinhart Tanoto
   4. Mark Veleba
   5. Kimberly Kline
   6. Guillaume Thibault

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Wounds are commonly infected, which can lead to delayed or poor wound healing, thereby significantly impacting morbidity and overall quality of life for patients. This manuscript uses single cell RNA sequencing to try to understand the impact of infection on various cell types during wound healing in a mouse model. The methodology is solid and the results provide a valuable 'atlas' of the cellular changes associated with infected and uninfected wounds which will be of interest to the field.

   Reviewed by eLife

7. Decoupling of the onset of anharmonicity between a protein and its surface water around 200 K

   This article has 11 authors:

   1. Lirong Zheng
   2. Bingxin Zhou
   3. Banghao Wu
   4. Yang Tan
   5. Juan Huang
   6. Madhusudan Tyagi
   7. Victoria García Sakai
   8. Takeshi Yamada
   9. Hugh O'Neill
   10. Qiu Zhang
   11. Liang Hong

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The study answers the important question of whether the conformational dynamics of proteins are slaved by the motion of solvent water or are intrinsic to the polypeptide. The results from neutron scattering experiments, involving isotopic labelling, carried out on a set of four structurally different proteins are convincing, showing that protein motions are not coupled to the solvent. A strength of this work is the study of a set of proteins using spectroscopy covering a range of resolutions. The work is of broad interest to researchers in the fields of protein biophysics and biochemistry.

   Reviewed by eLife

8. Xanthomonas citri subsp. citri type III effector PthA4 directs the dynamical expression of a putative citrus carbohydrate-binding protein gene for canker formation

   This article has 6 authors:

   1. Xinyu Chen
   2. Huasong Zou
   3. Tao Zhuo
   4. Wei Rou
   5. Wei Wu
   6. Xiaojing Fan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study provides new insight into potential subtle dynamics in effector biology. The data presented generally support the claims, but in some cases, significant controls are missing and so the overall work is currently incomplete. If the limitations can be addressed, this work should be of broad relevance for biologists interested in molecular plant-microbe interactions.

   Reviewed by eLife

9. ASAR lncRNAs control DNA replication timing through interactions with multiple hnRNP/RNA binding proteins

   This article has 5 authors:

   1. Mathew Thayer
   2. Michael B Heskett
   3. Leslie G Smith
   4. Paul T Spellman
   5. Phillip A Yates

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study expands generally upon our understanding of the role of hnRNP proteins in lncRNA function through analysis of ASAR genes that are present on all chromosomes and of profound significance. The findings provide convincing evidence linking ASARs with the phenomenon of RNA retention on chromosomes, including X inactivation, thereby providing an expanded context for studies in these areas. This manuscript will be of interest to researchers studying gene regulation and the interactions and functional roles of hnRNP and lncRNAs.

   Reviewed by eLife

10. Apical constriction requires patterned apical surface remodeling to synchronize cellular deformation

    This article has 3 authors:

    1. Satoshi Yamashita
    2. Shuji Ishihara
    3. François Graner

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      The results from this study, which investigates the mechanisms necessary for initiating tissue invagination using a cellular Potts modelling approach, suggest that apical constriction is not sufficient to drive the process by itself. The study highlights how choices inherent to modelling - such as permitting straight or curved cell edges - may affect the outcome of simulations and, consequently, their biophysical interpretation. Despite incomplete evidence supporting their major claims due to a rather coarse-grained exploration of the model, this work is useful for biophysicists investigating complex tissue deformation through computational frameworks.

    Reviewed by eLife