eLife

Latest preprint reviews

1. Adrenomedullin restores the human cortical interneurons migration defects induced by hypoxia

   This article has 14 authors:

   1. Alyssa Puno
   2. Wojciech P Michno
   3. Li Li
   4. Amanda Everitt
   5. Kate McCluskey
   6. Saw Htun
   7. Dhriti Nagar
   8. Jong Bin Choi
   9. Yuqin Dai
   10. Seyeon Park
   11. Emily Gurwitz
   12. A Jeremy Willsey
   13. Fikri Birey
   14. Anca M Pasca

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this manuscript, the authors investigate the migration of human cortical interneurons under hypoxic conditions using forebrain assembloids and developing human brain tissue, and probe the underlying mechanisms. The study provides the first direct evidence that hypoxia delays interneuron migration and identifies adrenomedullin (ADM) as a potential therapeutic intervention. The findings are important, and the conclusions are convincingly supported by experimental evidence.

   Reviewed by eLife

2. Sp Transcription Factors Establish the Signaling Environment in the Neuromesodermal Progenitor Niche During Axial Elongation

   This article has 11 authors:

   1. Ravindra B Chalamalasetty
   2. Haley Tran
   3. Ryan Kelly
   4. Samuel Kuo
   5. Mark W Kennedy
   6. Moonsup Lee
   7. Sara Thomas
   8. Nikolaos Mandalos
   9. Vishal Koparde
   10. Francisco Pereira Lobo
   11. Terry P Yamaguchi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This fundamental work advances our understanding of how SP5 and SP8 promote neuromesodermal competent progenitors in murine embryos. Generally the evidence is compelling, with strong developmental genetics, transcriptomic, and genomic transcription binding surveys contributing to the strength of the data. Some of the language could be softened to avoid overinterpretation of the data, and figures and diagrams could be improved.

   Reviewed by eLife

3. Cortical projection neurons with distinct axonal connectivity employ ribosomal complexes with distinct protein compositions

   This article has 4 authors:

   1. Tien Phuoc Tran
   2. Bogdan Budnik
   3. John E Froberg
   4. Jeffrey D Macklis

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents a valuable and rigorous molecular resource, offering subtype-specific insight into the composition of ribosome-associated protein complexes in the developing cerebral cortex. The evidence is compelling in terms of data quality and is strongly supported by the results, given the rigorous technical execution. However, the findings remain primarily descriptive, as the study lacks functional validation to support mechanistic conclusions.

   Reviewed by eLife

4. Morphology and ultrastructure of pharyngeal sense organs of Drosophila larvae

   This article has 4 authors:

   1. Vincent Richter
   2. Tilman Triphan
   3. Albert Cardona
   4. Andreas S Thum

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     In this fundamental manuscript, Richter et al. present a thorough anatomical characterization of the Drosophila melanogaster larval pharyngeal sensory system, which is involved in taste-guided behaviors. This study fills a major gap in the larval sensory map, providing a compelling neuroanatomical foundation for future investigations into sensory circuits and behavior. The data presented here are of exceptional quality and will be of interest to the Drosophila neurobiology community.

   Reviewed by eLife

5. Human neurocomputational mechanisms of guilt-driven and shame-driven altruistic behavior

   This article has 7 authors:

   1. Ruida Zhu
   2. Huanqing Wang
   3. Chunliang Feng
   4. Linyuan Yin
   5. Ran Zhang
   6. Yi Zeng
   7. Chao Liu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study on how dissociable emotions of shame and guilt emerge from cognitive processes and guide behavioral responses. The task is well designed and yields compelling behavioral, computational, and neural evidence elucidating the cognitive link between emotions and compensatory decisions. The work has broad theoretical and practical implications across a range of disciplines concerned with human behavior, including psychology, neuroscience, economics, public policy, and psychiatry.

   Reviewed by eLife

6. Criticality-driven enhancer-promoter dynamics in Drosophila chromosomes

   This article has 4 authors:

   1. Gautham Ganesh
   2. Jean-Bernard Fiche
   3. Marcelo Nöllmann
   4. Julien Mozziconacci

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript uses modeling approaches to provide mechanistic insight into the structural and dynamic properties of enhancer-promoter interactions in Drosophila. Given the interest in this field, this is a timely approach, and the results give useful insights by providing predictions about the processivity of cohesin loop extrusion in Drosophila and concluding that the compartmental interaction strength is poised near criticality in the coil-globule phase space. The evidence provided to support some of the conclusions is, however, incomplete and would be strengthened by better considering some of the caveats in the data used to constrain the models, such as the use of "homie" genetic elements in the dynamic data. There is insufficient evidence provided for the dynamics being criticality-driven, and in addition, consideration of alternative models would further strengthen the conclusions of the manuscript.

   Reviewed by eLife

7. RubyACRs Enable Red-Shifted Optogenetic Inhibition in Freely Behaving Drosophila

   This article has 9 authors:

   1. Daniel Bushey
   2. Hiroshi Shiozaki
   3. Yichun Shuai
   4. Jihong Zheng
   5. Vivek Jayaraman
   6. Jeremy P Hasseman
   7. Ilya Kolb
   8. GENIE Project Team
   9. Glenn C Turner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important work describes the adaptation and evaluation of two red-shifted anion channelrhodopsins (RubyACRs) for optogenetic inhibition in Drosophila. The study provides convincing evidence for the effectiveness of RubyACRs in fly neurons, including electrophysiology, calcium imaging, and behavioral analysis. With minor revisions to address potential toxicity and compatibility with 2-photon imaging, this paper and the publicly available fly lines it describes will be resources that are of value to the neuroscience community.

   Reviewed by eLife

8. Mycobacterial Metallophosphatase MmpE Acts as a Nucleomodulin to Regulate Host Gene Expression and Promote Intracellular Survival

   This article has 7 authors:

   1. Liu Chen
   2. Baojie Duan
   3. Qiang Jiang
   4. Yifan Wang
   5. Yingyu Chen
   6. Lei Zhang
   7. Aizhen Guo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript is useful as it demonstrates that Rv2577, a Fe³⁺/Zn²⁺-dependent metallophosphatase, is secreted by Mycobacterium bovis BCG and localizes to the nucleus of mammalian cells, altering transcriptional and inflammatory responses. However, the study is incomplete as it lacks activity validation in macrophage cells and with virulent Mycobacterium tuberculosis strains. It is necessary to confirm Rv2577 secretion from a virulent strain and to clarify the direct or indirect role of MmpE in modulating host pathways, together with mechanistic insight into how MmpE influences lysosomal biogenesis and trafficking.

   Reviewed by eLife

9. Decision-making components and times revealed by the single-trial electro-encephalogram

   This article has 3 authors:

   1. Gabriel Weindel
   2. Jelmer P Borst
   3. Leendert van Maanen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Weindel et al examine behavioural and EEG data in an innovative contrast comparison paradigm where they vary mean contrast widely while keeping contrast difference constant. As intended, this allowed an elegant decomposition of processing stages: while sensory encoding shortened with increasing contrast in keeping with Pieron's law, the period of decision formation lengthened, in keeping with Fechner's law, which was applied to drift rates in a diffusion model of that period. This is an important demonstration of how these two laws apply in concert, to two distinct processing levels, and the multivariate topography parsing, mixed effect models and diffusion models are convincing.

   Reviewed by eLife

10. iGABASnFR2: Improved genetically encoded protein sensors of GABA

    This article has 19 authors:

    1. Ilya Kolb
    2. Jeremy P Hasseman
    3. Akihiro Matsumoto
    4. Thomas P Jensen
    5. Olga Kopach
    6. Benjamin J Arthur
    7. Yan Zhang
    8. Arthur Tsang
    9. Daniel Reep
    10. Getahun Tsegaye
    11. Jihong Zheng
    12. Ronak H Patel
    13. Loren L Looger
    14. Jonathan S Marvin
    15. Wyatt L Korff
    16. Dmitri A Rusakov
    17. Keisuke Yonehara
    18. GENIE Project Team
    19. Glenn C Turner

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This manuscript reports the development and characterization of iGABASnFR2, a genetically encoded GABA sensor that demonstrates substantially improved performance compared to its predecessor, iGABASnFR1. The work is comprehensive and methodologically rigorous, combining high-throughput mutagenesis, functional screening, structural analysis, biophysical characterization, and in vivo validation. The significance of the findings is fundamental, and the supporting evidence is compelling. iGABASnFR2 represents a notable advance in GABA sensor engineering, enabling enhanced imaging of GABA transmission both in brain slices and in vivo, and constitutes a timely, technically robust addition to the molecular toolkit for neuroscience research.

    Reviewed by eLife, PREreview