Latest preprint reviews

1. Sex-dependent gastrointestinal colonization resistance to MRSA is microbiome and Th17 dependent

   This article has 12 authors:

   1. Alannah Lejeune
   2. Chunyi Zhou
   3. Defne Ercelen
   4. Gregory Putzel
   5. Xiaomin Yao
   6. Alyson R Guy
   7. Miranda Pawline
   8. Magdalena Podkowik
   9. Alejandro Pironti
   10. Victor J Torres
   11. Bo Shopsin
   12. Ken Cadwell

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study demonstrates a mechanism underlying the sex-dependent regulation of the susceptibility to gut colonization by Methicillin-resistant Staphylococcus aureus (MRSA). The evidence supporting the conclusion is solid, but additional experiments would strengthen the findings. The work will interest biologists who are working on intestinal infection and immunity.

   Reviewed by eLife

2. Cortico-striatal action control inherent of opponent cognitive-motivational styles

   This article has 2 authors:

   1. Cassandra Avila
   2. Martin Sarter

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable manuscript investigated the role of glutamate signaling in the dorsomedial striatum of rats in a treadmill-based task and reported that it differs in goal-trackers compared to sign-trackers in a way that corresponds to differences in behaviour. The evidence supporting these claims is solid but could be further strengthened by adding more analyses and more detailed descriptions of current analyses. These findings will primarily be of interest to behavioural neuroscientists.

   Reviewed by eLife

3. Elucidating the kinetic and thermodynamic insight into regulation of glycolysis by lactate dehydrogenase and its impact on tricarboxylic acid cycle and oxidative phosphorylation in cancer cells

   This article has 8 authors:

   1. Siying Zeng
   2. Yuqi Wang
   3. Minfeng Ying
   4. Chengmeng Jin
   5. Chang Ying
   6. Di Wang
   7. Hao Wu
   8. Xun Hu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents an assessment of the effect of lactate dehydrogenase (LDH) inhibition on the activity of glycolysis and tricarboxylic acid cycle. The data were collected and analyzed using solid and validated methodology. This paper makes a useful contribution to the field as it considers a control analysis of LDH flux.

   Reviewed by eLife

4. ATP burst is the dominant driver of antibiotic lethality in Mycobacteria

   This article has 6 authors:

   1. Tejan Lodhiya
   2. Aseem Palande
   3. Anjali Veeram
   4. Gerald Larrouy-Maumus
   5. Dany J V Beste
   6. Raju Mukherjee

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable work, Lodhiya et al. provide evidence that excessive ATP underlies the killing of the model organism Mycobacterium smegmatis by two mechanistically-distinct antibiotics. Clarification of the role(s) of reactive oxygen species and ADP, as well as discrepancies with existing literature, would strengthen the model proposed. The data are generally solid as the authors deploy multiple, orthogonal readouts and methods for manipulating reactive oxygen species and ATP. The work will be of interest to those studying antibiotic mechanisms of action.

   Reviewed by eLife

5. A new preprocedural predictive risk model for post-endoscopic retrograde cholangiopancreatography pancreatitis: The SuPER model

   This article has 17 authors:

   1. Mitsuru Sugimoto
   2. Tadayuki Takagi
   3. Tomohiro Suzuki
   4. Hiroshi Shimizu
   5. Goro Shibukawa
   6. Yuki Nakajima
   7. Yutaro Takeda
   8. Yuki Noguchi
   9. Reiko Kobayashi
   10. Hidemichi Imamura
   11. Hiroyuki Asama
   12. Naoki Konno
   13. Yuichi Waragai
   14. Hidenobu Akatsuka
   15. Rei Suzuki
   16. Takuto Hikichi
   17. Hiromasa Ohira

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study discusses a hot topic in post-endoscopic retrograde cholangiopancreatography pancreatitis. The new score for predicting post-ERCP pancreatitis offers an idea about the risk of pancreatitis before the procedure. Although most scores depend on intraprocedural manoeuvres, such as the number of attempts to cannulate the papilla, this is a solid retrospective single-center study in one country. To be validated, this score should be done in many countries and on large numbers of patients, nevertheless, this paper should interest gastrointestinal endoscopists.

   Reviewed by eLife

6. History-dependent spiking facilitates efficient encoding of polarization angles in neurons of the central complex

   This article has 3 authors:

   1. Lisa Rother
   2. Anna Stöckl
   3. Keram Pfeiffer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study combines electrophysiology experiments and modeling to investigate the encoding of dynamic patterns of polarized light by identified neurons of the bumblebee central complex. The scientific question and methodology are compelling. However, the evidence supporting the authors' conclusions is incomplete without more comprehensive statistical analyses.

   Reviewed by eLife

7. Executioner caspase is proximal to Fasciclin 3 which facilitates non-lethal activation in Drosophila olfactory receptor neurons

   This article has 6 authors:

   1. Masaya Muramoto
   2. Nozomi Hanawa
   3. Misako Okumura
   4. Takahiro Chihara
   5. Masayuki Miura
   6. Natsuki Shinoda

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study combines multiple techniques to investigate how caspase activity regulates non-lethal caspase-dependent processes. Through a combination of various approaches, and the development of new techniques, the authors provide compelling evidence supporting the claim that Fas3G-overexpression promotes non-lethal caspase activation in olfactory receptor neurons.

   Reviewed by eLife

8. Phase transition of WTAP regulates m6A modification of interferon-stimulated genes

   This article has 7 authors:

   1. Sihui Cai
   2. Jie Zhou
   3. Xiaotong Luo
   4. Chenqiu Zhang
   5. Shouheng Jin
   6. Jian Ren
   7. Jun Cui

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study demonstrates that interferon beta stimulation induces WTAP transition from aggregates to liquid droplets, coordinating m6A modification of a subset of mRNAs that encode interferon-stimulated genes and restricting their expression. The evidence presented is solid, supported by microscopy, immunoprecipitations, m6A sequencing, and ChIP, to show that WTAP phosphorylation controls phase transition and its interaction with STAT1 and the methyltransferase complex.

   Reviewed by eLife

9. Complement 3a Receptor 1 on Macrophages and Kupffer cells is not required for the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease

   This article has 9 authors:

   1. Edwin A. Homan
   2. Ankit Gilani
   3. Alfonso Rubio-Navarro
   4. Maya A. Johnson
   5. Odin M. Schaepkens
   6. Eric Cortada
   7. Renan Pereira de Lima
   8. Lisa Stoll
   9. James C. Lo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This useful study investigates the role of Complement 3a Receptor 1 (C3aR) in the pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) using mouse models with specific target deletions in various cell types. While the relevance of C3aR in inflammatory contexts has been established, the authors provide helpful but incomplete evidence that C3aR does not contribute significantly to MASLD pathogenesis in their models, a claim that would require additional experiments for support.

   Reviewed by eLife

10. Ly6G+Granulocytes-derived IL-17 limits protective host responses and promotes tuberculosis pathogenesis

    This article has 21 authors:

    1. Priya Sharma
    2. Raman Deep Sharma
    3. Mrinmoy Das
    4. Binayak Sarkar
    5. Lakshyaveer Singh
    6. Neharika Jain
    7. Shivam Chaturvedi
    8. Lalita Mehra
    9. Aditya Rathee
    10. Shilpa Sharma
    11. Shihui Foo
    12. Andrea Lee
    13. N Pavan kumar
    14. Prasenjit Das
    15. Vijay Viswanathan
    16. Hardy Kornfeld
    17. Shanshan W Howland
    18. Subash Babu
    19. Vinay Nandicoori
    20. Amit Singhal
    21. Dhiraj Kumar

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This potentially valuable study examines the role of IL17-producing Ly6G PMNs as a reservoir for Mycobacterium tuberculosis to evade host killing activated by BCG immunisation. The authors report that IL17-producing polymorphonuclear neutrophils harbour a significant bacterial load in both wild-type and IFNg-/- mice and that targeting IL17 and Cox2 improved disease outcomes whilst enhancing BCG efficacy. Although the authors suggest that targeting these pathways may improve disease outcomes in humans, the evidence as it stands is incomplete and requires additional experimentation for the study to realise its full impact.

    Reviewed by eLife