eLife

Latest preprint reviews

1. Continuous flashing suppression of neural responses and population orientation coding in macaque V1

   This article has 5 authors:

   1. Cai-Xia Chen
   2. Xin Wang
   3. Dan-Qing Jiang
   4. Shi-Ming Tang
   5. Cong Yu

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study shows that orientation tuning of V1 neurons is suppressed during a continuous flash suppression paradigm, especially in neurons with binocular receptive fields. These findings, made using cutting-edge imaging techniques, convincingly implicate early visual processing in continuous flash suppression, in agreement with previous studies suggesting reduced effective contrast of such stimuli in V1.

   Reviewed by eLife

2. In-situ glial cell-surface proteomics identifies pro-longevity factors in Drosophila

   This article has 22 authors:

   1. Madeline P Marques
   2. Bo Sun
   3. Ye-Jin Park
   4. Tyler Jackson
   5. Tzu-Chiao Lu
   6. Yanyan Qi
   7. Erin Harrison
   8. Miranda C Wang
   9. Kartik Venkatachalam
   10. Omar Moussa Pasha
   11. Amogh Varanasi
   12. Dominique Kiki Carey
   13. DR Mani
   14. Jonathan Zirin
   15. Mujeeb Qadiri
   16. Yanhui Hu
   17. Norbert Perrimon
   18. Steven A Carr
   19. Namrata D Udeshi
   20. Liqun Luo
   21. Jiefu Li
   22. Hongjie Li

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Combining state-of-the-art in-situ cell-surface proteomics, functional genetic screening, and single-nucleus RNA sequencing, this fundamental work substantially advances our understanding of glial contributions to organismal lifespan. The evidence supporting the conclusions is compelling, although additional clarification, control experiments, and analysis would further strengthen the study. The work will be of broad interest to researchers studying aging biology, glia-neuron communication, and in vivo proteomic profiling.

   Reviewed by eLife

3. Characterisation of cold-selective lamina I spinal projection neurons

   This article has 12 authors:

   1. Aimi N Razlan
   2. Wenhui Ma
   3. Allen C Dickie
   4. Erika Polgár
   5. Anna McFarlane
   6. Mansi Yadav
   7. Andrew H Cooper
   8. Douglas Strathdee
   9. Masahiko Watanabe
   10. Andrew M Bell
   11. Andrew J Todd
   12. Junichi Hachisuka

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study offers valuable insights into the anatomical and physiological features of cold-selective lamina I spinal projection neurons. The evidence supporting the authors' claims is convincing, although including a larger sample size and more quantification would have strengthened the study further, and the claims of monosynaptic connectivity would benefit from being stated more cautiously. The work will interest those in the field of somatosensory biology, especially researchers studying spinal cord dorsal horn circuits and projection neuron cell types.

   Reviewed by eLife

4. How Occam’s razor guides human decision-making

   This article has 5 authors:

   1. Eugenio Piasini
   2. Shuze Liu
   3. Pratik Chaudhari
   4. Vijay Balasubramanian
   5. Joshua I Gold

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an important new approach to quantifying parsimony preferences in human inference. The work provides convincing evidence that humans are sensitive to specific formalizations of parsimony, such as the dimensionality of perceptual shapes. The work is considered timely, well-written, and technically sophisticated, effectively bridging concepts from statistical inference and human decision-making.

   Reviewed by eLife

5. EEG decodability of facial expressions and their stereoscopic depth cues in immersive virtual reality

   This article has 7 authors:

   1. Felix Klotzsche
   2. Ammara Nasim
   3. Simon M Hofmann
   4. Arno Villringer
   5. Vadim Nikulin
   6. Werner Sommer
   7. Michael Gaebler

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study successfully decoded visual representations of facial expressions and stereoscopic depth information from electroencephalogram (EEG) signals recorded in an immersive virtual reality (VR) environment. The evidence is solid in demonstrating the technical feasibility of integrating state-of-the-art EEG decoding and VR with eye tracking. This work will interest neuroscience researchers, as well as engineers developing brain-machine interfaces and/or virtual reality displays.

   Reviewed by eLife

6. Persistent contacts between Climp63 and microtubules cause mitotic defects and nuclear fragmentation

   This article has 2 authors:

   1. Jelmi uit de Bos
   2. Ulrike Kutay

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reveals that mitotic release of an ER-microtubule tether is critical for normal mitotic progression. Manipulating CLIMP63 phosphorylation, the authors provide convincing evidence that persistent microtubule-ER contacts activate the spindle assembly checkpoint and, if mitosis is forced to proceed, drive severe micronucleation. While the study provides new mechanistic insights, some evidence is indirect, and additional experiments would further refine the model.

   Reviewed by eLife

7. Frequency-selective contrast sensitivity modulation driven by fine-tuned exogenous attention at the foveal scale

   This article has 3 authors:

   1. Yue Guzhang
   2. T Florian Jaeger
   3. Martina Poletti

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study explores how exogenous attention operates at the finest spatial scale of vision, within the foveola - a topic that has not been previously explored. The question is important for understanding how attention shapes perception, and how it differs between the periphery and the central regions of highest visual acuity. The evidence is compelling, as shown by carefully designed experiments with state-of-the-art eye tracking to monitor attended locations just a few tens of minutes of arc away from the fixation target, but additional clarification regarding analyses and implications for vision and oculomotor control would broaden the impact of the study.

   Reviewed by eLife

8. Learning-Associated Flexibility of Cortical Taste Coding Is Impaired in Shank3 Knockout Mice

   This article has 2 authors:

   1. Chi-Hong Wu
   2. Gina G Turrigiano

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study provides solid evidence for deficits in aversive taste learning and taste coding in a mouse model of autism spectrum disorders. Specifically, the authors found that Shank3 knockout mice exhibit behavioral deficits in learning and extinction of conditioned taste aversion, and calcium imaging of the gustatory cortex identified impaired neuronal responses to taste stimuli. This paper will likely be of interest to researchers studying how learning and sensory processes are affected by genetic causes of autism spectrum disorders.

   Reviewed by eLife

9. Robust and replicable effects of ageing on resting state brain electrophysiology measured with MEG

   This article has 7 authors:

   1. Andrew J Quinn
   2. Jemma Pitt
   3. Oliver Kohl
   4. Chetan Gohil
   5. Mats WJ van Es
   6. Anna C Nobre
   7. Mark W Woolrich

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     The authors ask whether a simple whole-head spectral power analysis of human magnetoencephalography data recorded at rest in a large cohort of adults shows robust effects of age, and their results provide compelling evidence that it does. The relative simplicity of the analysis is a major strength of the paper, and the authors are careful to control for many different confounds - although perhaps highly correlated factors like brain anatomy still pose a slight issue. The paper provides a valuable power analysis framework that should inform researchers across the broader neuroimaging community

   Reviewed by eLife

10. Thymic selection of the T cell receptor repertoire is biased toward autoimmunity in females

    This article has 18 authors:

    1. Hélène Vantomme
    2. Valentin Quiniou
    3. Leslie Adda
    4. Charline Jouannet
    5. Vanessa Mhanna
    6. Céline Albalaa
    7. Pierre Barennes
    8. Nicolas Coatnoan
    9. Vimala Diderot
    10. Johanna Dubois
    11. Gwladys Fourcade
    12. Kenz Le Gouge
    13. Otriv Frédéric Nguekap Tchoumba
    14. Martin Pezous
    15. Paul Stys
    16. Adrien Six
    17. Encarnita Mariotti-Ferrandiz
    18. David Klatzmann

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study provides valuable insights into addressing the question of whether the prevalence of autoimmune disease could be driven by sex differences in the T cell receptor (TCR) repertoire, correlating with higher rates of autoimmune disease in females. The authors compared male and female TCR repertoires using bulk RNA sequencing, from sorted thymocyte subpopulations in pediatric and adult human thymuses; however, the analyses provided do not provide sufficient discrimination and incompletely support the central claims regarding sex differences in the TCR repertoire and potential autoimmune bias.

    Reviewed by eLife