eLife

Latest preprint reviews

1. Neural bases of space-specific distractor biases in visual working memory

   This article has 3 authors:

   1. Deepak V Raya
   2. Sanchit Gupta
   3. Devarajan Sridharan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This useful study combines behavioral reports, EEG decoding, and computational modeling to address an interesting question: how delay-period distractors bias working-memory representations, and how these effects depend on target relevance, distractor location, and the strength of memory maintenance and distractor encoding. However, the supporting evidence is incomplete, as several key claims require clearer statistical tests, better integration of the behavioral and neural results, and more careful consideration of alternative explanations. Stronger engagement with prior literature would also substantially strengthen the manuscript and increase its potential interest to researchers in systems, cognitive, and computational neuroscience.

   Reviewed by eLife

2. Structural basis of CO2 valence coding in Drosophila

   This article has 7 authors:

   1. Dominik Javorski
   2. Beate Bergkirchner
   3. Gernot Ensinger
   4. Alexander Lingl
   5. Jelena Navolic
   6. Ashwaq Batawi
   7. Thomas Hummel

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides a detailed anatomical and functional framework for understanding CO₂ processing and behavioral flexibility in Drosophila. The significance of the work is important, as it identifies how specific neural circuits, such as LN23, modulate innately aversive signals across different contexts. The strength of the evidence is convincing, supported by a robust combination of connectomics, anatomical reconstructions, and targeted behavioral manipulations.

   Reviewed by eLife

3. Bayesian causal inference unifies perceptual and neuronal processing of center-surround motion in area MT

   This article has 4 authors:

   1. Gabor Lengyel
   2. Sabyasachi Shivkumar
   3. Gregory C DeAngelis
   4. Ralf M Haefner

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This manuscript represents a valuable contribution to understanding motion processing in the visual cortex. Based on a heterogeneous collection of previous empirical findings, the authors show that the diversity of tuning curves in the middle temporal (MT) area, in response to moving center-surround images, can be explained by Bayesian inference combined with neural sampling. The model rests on strong and solid assumptions about the prior and likelihood; independent evidence that neither of these factors is misspecified would strengthen the work.

   Reviewed by eLife

4. We couldn't get details of this article at this time:
   10.64898/2026.03.24.714006

5. We couldn't get details of this article at this time:
   10.64898/2026.03.12.711345

6. Identifying and targeting the Mg-Fe-PmrAB regulatory circuit reverses phosphate starvation-driven polymyxin resistance in Enterobacteriaceae

   This article has 7 authors:

   1. Guangming Zhang
   2. Ziqing Deng
   3. Jiezhang Jiang
   4. Minji Wang
   5. Xiaoyuan Wang
   6. Xiaoyun Liu
   7. Aixin Yan

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study characterizes a potentially targetable mechanism by which phosphate scarcity drives polymyxin B resistance in Enterobacteriaceae. The findings are important. While some aspects of the approach are very strong, particularly the diversity of techniques, it is recommended to include genetic controls and antibiotic resistance experiments in order to strengthen the evidence, which is currently solid. The clarity and presentation of the findings could also be improved.

   Reviewed by eLife

7. Developmental Synchrony of Retinal Waves, Apoptosis, and Angiogenesis in Postnatal Retina

   This article has 8 authors:

   1. Michael A Savage
   2. Cori Bertram
   3. Jean de Montigny
   4. Courtney A Thorne
   5. Rachel Queen
   6. Majlinda Lako
   7. Gerrit Hilgen
   8. Evelyne Sernagor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study identifies apoptotic retinal ganglion cells as a potential source of ATP-mediated activation of PANX1 channels that initiates developmental retinal Ca²⁺ waves and coordinates microglial activation and vascular outgrowth during postnatal maturation. The work is important because it proposes an integrative framework linking programmed cell death, spontaneous neural activity, immune responses, and angiogenesis into a self-regulating developmental loop. Although the mechanistic conclusions would benefit from complementary genetic validation, the study provides a convincing foundation for future investigations into the coordination of neural circuit development and tissue remodeling.

   Reviewed by eLife

8. PIK3CA-related overgrowth spectrum (PROS) zebrafish models reveal pan-lineage developmental dysregulation

   This article has 6 authors:

   1. Hannah Brunsdon
   2. Nuoya Wang
   3. Micha Sam Brickman Raredon
   4. Ralitsa R Madsen
   5. Robert K Semple
   6. E Elizabeth Patton

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This is an important study that establishes a zebrafish model of PIK3CA-related overgrowth syndrome. The imaging characterization of the mesodermal, particularly vascular, lesions of the model is compelling. The scRNA-Seq analysis is convincing, revealing key perturbations in the PIK3CA-mutation model, although deeper investigation of the exact mechanism leading to the lesions, as well as validation at different time points, could further strengthen the findings. This work will be of interest to medical biologists working on PROS, and potentially to a broader audience interested in non-cell-autonomous signaling of PIK3CA and its implications in other diseases.

   Reviewed by eLife

9. Single-cell spatial mapping reveals reproducible cell type organization and spatially-dependent gene expression in gastruloids

   This article has 4 authors:

   1. Catherine G Triandafillou
   2. Pranav Sompalle
   3. Yael Heyman
   4. Arjun Raj

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work presents important findings on quantifying gene coexpression from spatial omics. These quantification methods have been applied to gastruloid to describe how genes are spatialised. The description of the quantifying tools is characterized by exceptional evidence after a thorough revision.

   Reviewed by eLife

10. Essential function reflected in the phylodynamics of a multigene family – the pir genes of malaria parasites

    This article has 14 authors:

    1. Andrew P Jackson
    2. Deirdre A Cunningham
    3. Lin Lin
    4. Naomi Mara Claro de Oliveira
    5. Séverine C Chevalley-Maurel
    6. Giulia Pianta
    7. Franziska Morhing
    8. Abigail K Renfree
    9. Timothy S Little
    10. Robert W Moon
    11. Jean Langhorne
    12. Chris J Janse
    13. Blandine MD Franke-Fayard
    14. Christiaan van Ooij

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable study provides the first broad cross-species evolutionary analysis of the pir multigene family in malaria parasites, showing that the family evolved through rapid duplication and loss while retaining a small number of conserved orthologs with essential functions. The authors identify pirC1 as a key determinant of parasite growth across multiple Plasmodium species. However, the work remains incomplete because the mechanistic role of PIRCl and its precise subcellular localization are not directly resolved.

    Reviewed by eLife