eLife

Latest preprint reviews

1. Expression of modified FcγRI enables myeloid cells to elicit robust tumor-specific cytotoxicity

   This article has 15 authors:

   1. Leen Farhat-Younis
   2. Manho Na
   3. Amichai Zarfin
   4. Aseel Khateeb
   5. Nadine Santana-Magal
   6. Alon Richter
   7. Amit Gutwillig
   8. Diana Rasoulouniriana
   9. Annette Gleiberman
   10. Lir Beck
   11. Tamar Giger
   12. Avraham Ashkenazi
   13. Adi Barzel
   14. Peleg Rider
   15. Yaron Carmi

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     The findings are fundamental for understanding IgM signaling in myeloid cells. The work is compelling in its ability to manipulate and harness myeloid cells to further anti-tumor immunity.

   Reviewed by eLife

2. A scenario for an evolutionary selection of ageing

   This article has 5 authors:

   1. Tristan Roget
   2. Claire Macmurray
   3. Pierre Jolivet
   4. Sylvie Meleard
   5. Michael Rera

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     Through a theoretical approach, this study makes important contributions to our understanding of the evolutionary causes of the ageing process. Using a simple individual-based model and computational simulations, the authors provide convincing evidence that ageing can be a trait under natural selection, opening the door for further discussion in the context of lifespan extension research.

   Reviewed by eLife

3. Language experience shapes predictive coding of rhythmic sound sequences

   This article has 5 authors:

   1. Piermatteo Morucci
   2. Sanjeev Nara
   3. Mikel Lizarazu
   4. Clara Martin
   5. Nicola Molinaro

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This study presents important observations about how the human brain uses long-term priors (acquired during our lifetime of listening) to make predictions about expected sounds - an open question in the field of predictive processing. The evidence presented is solid and based on state-of-the-art statistical analysis, but limited by a relatively low N and low magnitude for the interaction effect.

   Reviewed by eLife

4. Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry

   This article has 4 authors:

   1. Laurie Peverini
   2. Sophie Shi
   3. Karima Medjebeur
   4. Pierre-Jean Corringer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study applies voltage clamp fluorometry to provide new information about the function of serotonin-gated ion channels 5-HT3AR. The authors convincingly investigate structural changes inside and outside the orthosteric site elicited by agonists, partial agonists, and antagonists, helping to annotate existing cryo-EM structures. This work confirms that the activation of 5-HT3 receptors is similar to other members of this well-studied receptor superfamily. The work will be of interest to scientists working on channel biophysics but also drug development targeting ligand-gated ion channels.

   Reviewed by eLife

5. Mapping the molecular motions of 5-HT3 serotonin-gated channel by voltage-clamp fluorometry

   This article has 4 authors:

   1. Laurie Peverini
   2. Sophie Shi
   3. Karima Medjebeur
   4. Pierre-Jean Corringer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable study applies voltage clamp fluorometry to provide new information about the function of serotonin-gated ion channels 5-HT3AR. The authors convincingly investigate structural changes inside and outside the orthosteric site elicited by agonists, partial agonists, and antagonists, helping to annotate existing cryo-EM structures. This work confirms that the activation of 5-HT3 receptors is similar to other members of this well-studied receptor superfamily. The work will be of interest to scientists working on channel biophysics but also drug development targeting ligand-gated ion channels.

   Reviewed by eLife

6. Predicting the effect of CRISPR-Cas9-based epigenome editing

   This article has 7 authors:

   1. Sanjit Singh Batra
   2. Alan Cabrera
   3. Jeffrey P Spence
   4. Jacob Goell
   5. Selvalakshmi S Anand
   6. Isaac B Hilton
   7. Yun S Song

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an advance in efforts to use histone post-translational modification (PTM) data to model gene expression and to predict epigenetic editing activity. Such models are broadly useful to the research community, especially ones that can model and predict epigenetic editing activity, which is novel; additionally, the authors have nicely integrated datasets across cell types into their model. The work is mostly solid, but it would be strengthened by performing further comparisons to existing methods that predict gene expression from PTM data and from more comprehensive functional validation of model-predicted epigenome editing outcomes beyond dCas9-p300 based perturbations. This work will be of interest to the epigenetics and computational modeling communities.

   Reviewed by eLife

7. Botulinum toxin intoxication requires retrograde transport and membrane translocation at the ER in RenVM neurons

   This article has 9 authors:

   1. Jeremy C Yeo
   2. Felicia P Tay
   3. Rebecca Bennion
   4. Omar Loss
   5. Jacquie Maignel
   6. Laurent Pons
   7. Keith Foster
   8. Matthew Beard
   9. Frederic Bard

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this valuable manuscript, Yeo et al. describe new methods for assessing the intracellular itinerary of Botulinum neurotoxin A (BoNT/A), a potent toxin used in clinical and cosmetic applications. The current manuscript challenges previously held views on how the catalytic portion of the toxin makes its way from the endocytic compartment to the cytosol, to meet its substrates. The approach taken is deemed innovative and the experiments are carefully performed, presenting solid evidence for some of the drawn conclusion; however, the conclusions one may draw from the experimental results are somewhat limited, as it is possible that the scope of their findings could be restricted to the specific neuron model and molecular tools that were used. This paper could be of interest to both cell biologists and physicians.

   Reviewed by eLife

8. Human disturbance increases spatiotemporal associations among mountain forest terrestrial mammal species

   This article has 8 authors:

   1. Xueyou Li
   2. William V Bleisch
   3. Wenqiang Hu
   4. Quan Li
   5. Hongjiao Wang
   6. Zhongzheng Chen
   7. Ru Bai
   8. Xue-Long Jiang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     In this study, camera trapping and species distribution models are used to show that human disturbance in mountain forests in the eastern Himalayas pushes medium-sized and large mammal species into narrower habitat space, thus increasing their co-occurrence. While the collected data provide a useful basis for further work, the study presents incomplete evidence to support the claim that increased co-occurrence may indicate positive interactions between species.

   Reviewed by eLife

9. Structural and dynamic changes in P-Rex1 upon activation by PIP3 and inhibition by IP4

   This article has 8 authors:

   1. Sandeep K Ravala
   2. Sendi Rafael Adame-Garcia
   3. Sheng Li
   4. Chun-Liang Chen
   5. Michael A Cianfrocco
   6. J Silvio Gutkind
   7. Jennifer N Cash
   8. John JG Tesmer

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important study contributes insights into the regulatory mechanisms of a protein governing cell migration at the membrane. The integration of approaches revealing protein structure and dynamics provides convincing data for a model of regulation and suggests a new allosteric role for a solubilized phospholipid headgroup. The work will be interesting to researchers focusing on signaling mechanisms, cell motility, and cancer metathesis.

   Reviewed by eLife

10. The non-muscle actinopathy-associated mutation E334Q in cytoskeletal γ-actin perturbs interaction of actin filaments with myosin and ADF/cofilin family proteins

    This article has 8 authors:

    1. Johannes N Greve
    2. Anja Marquardt
    3. Robin Heiringhoff
    4. Theresia Reindl
    5. Claudia Thiel
    6. Nataliya Di Donato
    7. Manuel H Taft
    8. Dietmar J Manstein

    This article has been curated by 1 group:

    • Curated by eLife

      eLife assessment

      This study presents a valuable characterization of the biochemical consequences of a disease-associated point mutation in a nonmuscle actin. The study uses well-characterized in vitro assays to explore function. The data are convincing and should be helpful to others.

    Reviewed by eLife