Latest preprint reviews

  1. Loss of SPNS1, a lysosomal transporter, in the nervous system causes dysmyelination and white matter dysplasia

    This article has 11 authors:
    1. Yoshinobu Ichimura
    2. Yuki Sugiura
    3. Yoshinori Katsuragi
    4. Yu-Shin Sou
    5. Takefumi Uemura
    6. Naoki Tamura
    7. Satoko Komatsu-Hirota
    8. Takashi Ueno
    9. Masato Koike
    10. Satoshi Waguri
    11. Masaaki Komatsu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This paper presents useful findings on the dysmyelination phenotype of nervous system-specific Spns1 (a lysosomal lipid transporter) knockout mice. While the analysis of the phenotype is solid, the evidence for the underlying mechanisms, especially the molecular function for SPNS1, is incomplete. With more careful interpretation and/or additional experimental data, this work could have implications for understanding lipid transport and lysosomal storage diseases.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  2. Repix: reliable, reusable, versatile chronic Neuropixels implants using minimal components

    This article has 26 authors:
    1. Mattias Horan
    2. Daniel Regester
    3. Cristina Mazuski
    4. Thomas Jahans-Price
    5. Shanice Bailey
    6. Emmett Thompson
    7. Zuzanna Slonina
    8. Viktor Plattner
    9. Elena Menichini
    10. Irmak Toksöz
    11. Sandra Romero Pinto
    12. Mark Burrell
    13. Isabella Varsavsky
    14. Henry WP Dalgleish
    15. Célian Bimbard
    16. Anna Lebedeva
    17. Marius Bauza
    18. Francesca Cacucci
    19. Thomas Wills
    20. Athena Akrami
    21. Julija Krupic
    22. Marcus Stephenson-Jones
    23. Caswell Barry
    24. Neil Burgess
    25. John O’Keefe
    26. Yoh Isogai
    This article has been curated by 1 group:
    • Curated by eLife

      eLife assessment

      This report details the creation and wide-scale utilization of "Repix", a new technique for chronic neurophysiological recordings using and re-using Neuropixels probes in freely behaving mice and rats. The authors include data and feedback from a variety of labs and researchers who have used this technique, setting an example for open science and reproducibility, and providing convincing evidence that this approach can be employed for chronic Neuropixels recordings. However, evidence is currently incomplete for claims about the advantages of this design over previous approaches and for cell yield and stability claims. This important work will have an impact on a broad range of neuroscientists seeking a straightforward methodology for chronic Neuropixels recordings and will facilitate ethologically relevant experimental designs.

    Reviewed by eLife

    This article has 4 evaluationsAppears in 1 listLatest version Latest activity
  3. Structural insights into human propionyl-CoA carboxylase (PCC) and 3-methylcrotonyl-CoA carboxylase (MCC)

    This article has 6 authors:
    1. Fayang Zhou
    2. Yuanyuan Zhang
    3. Yuyao Zhu
    4. Qiang Zhou
    5. Yigong Shi
    6. Qi Hu
    This article has been curated by 1 group:
    • Curated by eLife

      eLife Assessment

      This study presents the cryo-EM structures of two human biotin-dependent mitochondria carboxylases involved in various biological pathways, including the metabolism of certain amino acids, cholesterol, and odd chain fatty acids. The cryo-EM structures offer a valuable addition to the structural description of biotin-dependent carboxylases and provide solid evidence to support the major conclusions of this study. This paper would be of interest to biochemists and structural biologists working on biotin-dependent carboxylases.

    Reviewed by eLife

    This article has 8 evaluationsAppears in 1 listLatest version Latest activity
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