eLife

Latest preprint reviews

1. Improving SARS-CoV-2 variants monitoring in the absence of genomic surveillance capabilities: a serological study in Bolivian blood donors in October 2021 and June 2022

   This article has 16 authors:

   1. Lucia Inchauste
   2. Elif Nurtop
   3. Lissete Bautista Machicado
   4. Yanine Leigue Roth
   5. Shirley Lenz Gonzales
   6. Maria Luisa Herrera
   7. Katty Mina Villafan
   8. Pedro Mamani Mamani
   9. Marcelo Ramos Espinoza
   10. Juan Carlos Pavel Suarez
   11. Juan Cansio Garcia Copa
   12. Yitzhak Leigue Zabala
   13. Etzel Arancibia Cardozo
   14. Pierre Gallian
   15. Xavier de Lamballerie
   16. Stéphane Priet

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This serostudy of blood donors in Bolivia (a country with very high COVID death rates in 2020-21) provides useful insights on the successive viral variants of SARS-CoV-2 over 2021 and 2022. Using compelling antibody and neutralization assays, the authors describe variant specific distributions in the different parts of Bolivia. The main methodological advance is to use serology to understand variant diversity, which in turn helps deepen understanding of "hybrid" immunity from widespread infection (and vaccination).

   Reviewed by eLife

2. Heparan sulfate-dependent phase separation of CCL5 and its chemotactic activity

   This article has 13 authors:

   1. Xiaolin Yu
   2. Guangfei Duan
   3. Pengfei Pei
   4. Long Chen
   5. Renji Gu
   6. Wenrui Hu
   7. Hongli Zhang
   8. Yan-Dong Wang
   9. Lili Gong
   10. Lihong Liu
   11. Ting-Ting Chu
   12. Jin-Ping Li
   13. Shi-Zhong Luo

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     How the triplicate interaction between chemokines with both GAGs and G protein-coupled receptors (GPCR) works and how gradients are created and potentially maintained in vivo are poorly understood. The authors provide solid evidence to show phase separation can drive chemotactic gradient formation. The paper is a useful advance in the field of chemokine biology.

   Reviewed by eLife

3. Predicting the causal relationship between polyunsaturated fatty acids and cerebral aneurysm risk from a Mendelian randomization study

   This article has 12 authors:

   1. Weijie Yu
   2. Liwei Zhou
   3. Chongfei Li
   4. Zhenwei Lu
   5. Xiaoyu Chen
   6. Hao Yu
   7. Xiaoyan Chen
   8. Qionghui Huang
   9. Zhangyu Li
   10. Deyong Xiao
   11. Yunyun Mei
   12. Zhanxiang Wang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Yu and colleagues used two-sample MR to test the effect of PUFA on cerebral aneurysms. They found that genetically predicted omega-3 and DHA decreased the risk for Intracranial Aneurysm and Subarachnoid Haemorrhage. This work is useful and the revised version provides solid evidence to support the claims.

   Reviewed by eLife

4. Editing of endogenous tubulins reveals varying effects of tubulin posttranslational modifications on axonal growth and regeneration

   This article has 4 authors:

   1. Yu-Ming Lu
   2. Shan Yan
   3. Shih-Chieh Ti
   4. Chaogu Zheng

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study analyzes the roles of post-translational modifications of tubulin by generating a large panel of tubulin mutants and describing their effects on morphogenesis and function of sensory neurons in C. elegans. The work, which is of interest to all cell biologists, in particular researchers with an interest in the microtubule cytoskeleton and neurobiology, presents conclusions that are supported by solid evidence. Demonstrating that all introduced mutations have the intended consequences and exploring their direct effect on microtubules would further increase the impact of the work.

   Reviewed by eLife

5. The cryo-EM structure of ASK1 reveals an asymmetric architecture allosterically modulated by TRX1

   This article has 4 authors:

   1. Karolina Honzejkova
   2. Dalibor Kosek
   3. Veronika Obsilova
   4. Tomas Obsil

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This important manuscript reports the cryo-EM structure of the ASK1 protein, which is a critical regulator of the MAPKs, JNKs, and p38 MAPKs in diverse cellular stress responses. The evidence of ASK1 interaction with TRX1 is compelling and will eventually allow the discovery of small molecule inhibitors of ASK1 activity.

   Reviewed by eLife

6. Telomere length sensitive regulation of interleukin receptor 1 type 1 (IL1R1) by the shelterin protein TRF2 modulates immune signalling in the tumour microenvironment

   This article has 21 authors:

   1. Ananda Kishore Mukherjee
   2. Subhajit Dutta
   3. Ankita Singh
   4. Shalu Sharma
   5. Shuvra Shekhar Roy
   6. Antara Sengupta
   7. Megha Chatterjee
   8. Soujanya Vinayagamurthy
   9. Sulochana Bagri
   10. Divya Khanna
   11. Meenakshi Verma
   12. Dristhi Soni
   13. Anshul Budharaja
   14. Sagar Kailasrao Bhisade
   15. Vivek Anand
   16. Ahmad Perwez
   17. Nija George
   18. Mohammed Faruq
   19. Ishaan Gupta
   20. Radhakrishnan Sabarinathan
   21. Shantanu Chowdhury

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study presents an important finding on the role of telomeres in modulating interleukin-1 signaling and tumor immunity in TNBC. The evidence supporting these findings is solid, presented through comprehensive analyses including TNBC clinical samples, tumor-derived organoids, cancer cells, and xenografts. The work will be of broad interest to cell and medical biologists focusing on TNBC.

   Reviewed by eLife

7. Enhancing bone regeneration and osseointegration using rhPTH(1-34) and dimeric R25CPTH(1-34) in an osteoporotic beagle model

   This article has 4 authors:

   1. Jeong-Oh Shin
   2. Jong-Bin Lee
   3. Sihoon Lee
   4. Jin-Woo Kim

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Using a large animal model, this study demonstrated valuable findings that R25CPTH(1-34), based on a mutation associated with isolated familial hypoparathyroidism, generated an anabolic osteointegration effect comparable to that of native PTH1-34. The translational aspect of this human-to-animal work, aimed at animal-to-human translation for therapeutic purposes, should be highlighted. The study design is simple and straightforward, and the methods used are solid. The authors have addressed all the questions in their revision.

   Reviewed by eLife

8. Disentangling the relationship between cancer mortality and COVID-19 in the US

   This article has 3 authors:

   1. Chelsea L Hansen
   2. Cécile Viboud
   3. Lone Simonsen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This valuable work explores death coding data to understand the impact of COVID-19 on cancer mortality. The work provides solid evidence that deaths with cancer as a contributing cause were not above what would be expected during pandemic waves, suggesting that cancer did not strongly increase the risk of dying of COVID-19. These results are an interesting exploration into the coding of causes of death that can be used to make sense of how deaths are coded during a pandemic in the presence of other underlying diseases, such as cancer.

   Reviewed by eLife

9. Rapid bacterial evaluation beyond the colony forming unit in osteomyelitis

   This article has 8 authors:

   1. Qi Sun
   2. Kimberley Huynh
   3. Dzenita Muratovic
   4. Nicholas J Gunn
   5. Anja R Zelmer
   6. Lucian Bogdan Solomon
   7. Gerald J Atkins
   8. Dongqing Yang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife assessment

     This fundamental study addresses discrepancies in determining bacterial burden in osteomyelitis as determined by culture and enumeration using DNA. The authors present compelling data demonstrating the emergence of discrepancies between CFU counts and genome copy numbers detected by PCR in Staphylococcus aureus strains infecting osteocyte-like cells. The observations represent a substantial addition to the field of musculoskeletal infection, with possible broad applicability and clinical benefit to other infectious diseases.

   Reviewed by eLife

10. Sperm fertility in mice with oligo-astheno-teratozoospermia restored by in vivo injection and electroporation of naked mRNA

    This article has 25 authors:

    1. Charline Vilpreux
    2. Guillaume Martinez
    3. Paul Fourquin
    4. Magali Court
    5. Florence Appaix
    6. Jean-Luc Duteyrat
    7. Maxime Henry
    8. Julien Vollaire
    9. Camille Ayad
    10. Altan Yavuz
    11. Lisa De Macedo
    12. Geneviève Chevalier
    13. Edgar Del Llano
    14. Emeline Lambert
    15. Sekou Ahmed Conte
    16. Zeina Wehbe
    17. Elsa Giordani
    18. Véronique Josserand
    19. Jacques Brocard
    20. Coutton Charles
    21. Bernard Verrier
    22. Pierre F Ray
    23. Corinne Loeuillet
    24. Christophe Arnoult
    25. Jessica Escoffier

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This study reports an approach for restoring sperm motility in mice. The strength lies in in the novelty of the methodology being developed, but the evidence for the success of the method or its mechanism is inadequate. Additional experimental support would be required to support the conclusions of the authors.

    Reviewed by eLife