Latest preprint reviews

1. Avian-specific Salmonella enterica Serovar Gallinarum transition to endemicity is accompanied by localized resistome and mobilome interaction

   This article has 12 authors:

   1. Chenghao Jia
   2. Chenghu Huang
   3. Haiyang Zhou
   4. Xiao Zhou
   5. Zining Wang
   6. Abubakar Siddique
   7. Xiamei Kang
   8. Qianzhe Cao
   9. Yingying Huang
   10. Fang He
   11. Yan Li
   12. Min Yue

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study uses a large dataset from both recent isolates and genomes in databases to provide an analysis of the population structure of the pathogen Salmonella gallinarum. The results regarding regional adaptation and the evolutionary trajectory of the resistome and mobilome remain incomplete, requiring additional details to fully support their claims and assess the value of these insights for future policy interventions regarding this and other pathogens. This work will interest microbiologists and researchers working on genomics, evolution, and antimicrobial resistance.

   Reviewed by eLife

2. A VgrG2b fragment cleaved by caspase-11/4 promotes Pseudomonas aeruginosa infection through suppressing the NLRP3 inflammasome

   This article has 10 authors:

   1. Yan Qian
   2. Qiannv Liu
   3. Xiangyun Cheng
   4. Chunlei Wang
   5. Chun Kong
   6. Mengqian Li
   7. Chao Ren
   8. Dong Jiang
   9. Shuo Wang
   10. Pengyan Xia

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This valuable study on strategies used by Pseudomonas to subvert hots immunity identifies a new immune evasion strategy. The study presents solid evidence on the cleavage of VgrG2B by Caspase 11 and the generation of fragments that inhibit activity of the NLRP3 inflammasome. This work should be of interest to immunologists and microbiologists.

   Reviewed by eLife

3. Quantification of Salmonella enterica serovar Typhimurium Population Dynamics in Murine Infection Using a Highly Diverse Barcoded Library

   This article has 5 authors:

   1. Julia A Hotinger
   2. Ian W Campbell
   3. Karthik Hullahalli
   4. Akina Osaki
   5. Matthew K Waldor

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study reports a detailed quantification of the population dynamics of Salmonella enterica serovar Typhimurium in mice. Bacterial burden and founding population sizes across various organs were quantified, revealing pathways of dissemination and reseeding of the gastrointestinal tract from systemic organs. Using various techniques, including genetic distance measurements, the authors present compelling evidence to support their conclusions, thus presenting new knowledge that will be of broad interest to scientists focusing on infectious diseases.

   Reviewed by eLife

4. Centrosome Migration and Apical Membrane Formation in Polarized Epithelial Cells: Insights from the MDCK Cyst Model

   This article has 3 authors:

   1. Po-Kai Wang
   2. Keng-Hui Lin
   3. Tang K Tang

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Wang et al's study addresses an important critical gap in our understanding of de novo epithelial polarization using MDCK cell doublets surrounded by ECM, providing convincing evidence through imaging and depletion studies on the role of conserved polarity proteins and the centrosome during this process. While the authors propose a clear hierarchical model, there is a need for further exploration of how microtubule organization contributes to this process. Specifically, live cell imaging of microtubules under mutants and their included ECM conditions, along with a more precise temporal mapping of microtubule dynamics in relation to proteins like Gp135, would strengthen the study's conclusions.

   Reviewed by eLife

5. The title and authors for this article are not available from our external data provider yet:
   10.48550/arxiv.2307.07654v3

6. Neural mechanisms of credit assignment for delayed outcomes during contingent learning

   This article has 7 authors:

   1. Phillip P Witkowski
   2. Lindsay Rondot
   3. Zeb Kurth-Nelson
   4. Mona M Garvert
   5. Raymond J Dolan
   6. Timothy EJ Behrens
   7. Erie D Boorman

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This study provides important findings that during credit assignment, the lateral orbitofrontal cortex (lOFC) and hippocampus (HC) encode causal choice representations, while the frontopolar cortex (FPl) mediates HC -lOFC interactions when the causality needs to be maintained over longer distractions. While this research offers compelling evidence and employs sophisticated multivariate pattern analysis, there are some concerns regarding a) task design which may have oversimplified real-world credit assignment complexities, and b) the interpretation of results. This work will be of interest to cognitive and computational neuroscientists who work on value-based decision-making and fronto-hippocampal circuits.

   Reviewed by eLife

7. Tripartite organization of brain state dynamics underlying spoken narrative comprehension

   This article has 4 authors:

   1. Lanfang Liu
   2. Jiahao Jiang
   3. Hehui Li
   4. Guosheng Ding

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     Liu and colleagues' study provides important insights into the neural mechanisms of narrative comprehension by identifying three distinct brain states using a hidden Markov model on fMRI data. The work is compelling, as it demonstrates that the dynamics of these brain states, particularly their timely expression, are linked to better comprehension and are specific to spoken language processing. The study's robust findings, validated in a separate dataset, will be of broad interest to researchers exploring the neural basis of speech and language comprehension, as well as those studying the relationship between dynamic brain states and cognition.

   Reviewed by eLife

8. Projections from thalamic nucleus reuniens to hippocampal CA1 area participate in context fear extinction by affecting extinction-induced molecular remodeling of excitatory synapses

   This article has 8 authors:

   1. Magdalena Ziółkowska
   2. Narges Sotoudeh
   3. Anna Cały
   4. Monika Puchalska
   5. Roberto Pagano
   6. Małgorzata Alicja Śliwińska
   7. Ahmad Salamian
   8. Kasia Radwanska

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This work provides important findings characterizing potential synaptic mechanisms supporting the role of midline thalamus-hippocampal projections in fear memory extinction in mice. The methods and approaches used were solid. However, the evidence itself is incomplete, as there are concerns with whether the findings fully support the conclusions drawn.

   Reviewed by eLife

9. Temporal dynamics analysis reveals that concurrent working memory load eliminates the Stroop effect through disrupting stimulus-response mapping

   This article has 6 authors:

   1. Yafen Li
   2. Yixuan Lin
   3. Qing Li
   4. Yongqiang Chen
   5. Zhifang Li
   6. Antao Chen

   This article has been curated by 1 group:

   • Curated by eLife

     eLife Assessment

     This important study investigates how working memory load influences the Stroop effect from a temporal dynamics perspective. Solid evidence is provided that the working memory load influences the Stroop effect in the late-stage stimulus-response mapping instead of the early sensory stage. This study will be of interest to both neuroscientists and psychologists who work on cognitive control.

   Reviewed by eLife

10. IFIT1 is rapidly evolving and exhibits disparate antiviral activities across 11 mammalian orders

    This article has 5 authors:

    1. Matthew B McDougal
    2. Anthony M De Maria
    3. Emi Nakahara
    4. Ian N Boys
    5. John W Schoggins

    This article has been curated by 1 group:

    • Curated by eLife

      eLife Assessment

      This valuable report describes the changing antiviral activity of IFIT1 across mammals and in response to distinct viruses, likely as a result of past arms races. One of the main strengths of the manuscript is the breadth of mammalian IFIT1 orthologs and viruses that were tested. Overall the evidence is solid, but the analysis of positive selection could benefit from more thorough validation with complementary selection tests and also from assessing or more extended discussion of the impact of recombination and/or physical interactions with other IFITs.

    Reviewed by eLife